Results 21 to 30 of about 840,592 (294)

Mitofusins and OPA1 Mediate Sequential Steps in Mitochondrial Membrane Fusion [PDF]

, 2009
Mitochondrial fusion requires the coordinated fusion of the outer and inner membranes. Three large GTPases—OPA1 and the mitofusins Mfn1 and Mfn2—are essential for the fusion of mammalian mitochondria.
David C. Chan, J. Michael Mccaffery, Janet M. Shaw, Mariam Ghochani, Terrence G. Frey, Zhiyin Song   +5 more
core   +2 more sources

Intracellular Vesicle Fusion Requires a Membrane-Destabilizing Peptide Located at the Juxtamembrane Region of the v-SNARE

Cell Reports, 2019
Summary: Intracellular vesicle fusion is mediated by soluble N-ethylmaleimide sensitive factor attachment protein receptors (SNAREs) and Sec1/Munc18 (SM) proteins. It is generally accepted that membrane fusion occurs when the vesicle and target membranes
Shailendra S. Rathore, Yinghui Liu, Haijia Yu, Chun Wan, MyeongSeon Lee, Qian Yin, Michael H.B. Stowell, Jingshi Shen   +7 more
doaj   +1 more source

Fusogenic pairings of vesicle-associated membrane proteins (VAMPs) and plasma membrane t-SNAREs--VAMP5 as the exception. [PDF]

PLoS ONE, 2010
Intracellular vesicle fusion is mediated by the interactions of SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) proteins on vesicles (v-SNAREs) and on target membranes (t-SNAREs).
Nazarul Hasan, Deborah Corbin, Chuan Hu
doaj   +1 more source

Computational insights into the membrane fusion mechanism of SARS-CoV-2 at the cellular level

Computational and Structural Biotechnology Journal, 2021
The membrane fusion mechanism of SARS-CoV-2 offers an attractive target for the development of small molecule antiviral inhibitors. Fusion involves an initial binding of the crown-like trimeric spike glycoproteins of SARS-CoV-2 to the receptor ...
Jimin Wang, Federica Maschietto, Matthew J. Guberman-Pfeffer, Krystle Reiss, Brandon Allen, Yong Xiong, Elias Lolis, Victor S. Batista   +7 more
doaj   +1 more source

Membrane interaction and structure of the transmembrane domain of influenza hemagglutinin and its fusion peptide complex

BMC Biology, 2008
Background To study the organization and interaction with the fusion domain (or fusion peptide, FP) of the transmembrane domain (TMD) of influenza virus envelope glycoprotein for its role in membrane fusion which is also essential in the cellular ...
Lin Chi-Hui, Kantchev Eric, Cheng Shu-Fang, Chang Ding-Kwo, Liu Yu-Tsan   +4 more
doaj   +1 more source

A virus-encoded cell-cell fusion machine dependent on surrogate adhesins. [PDF]

PLoS Pathogens, 2008
The reovirus fusion-associated small transmembrane (FAST) proteins function as virus-encoded cellular fusogens, mediating efficient cell-cell rather than virus-cell membrane fusion. With ectodomains of only approximately 20-40 residues, it is unclear how
Jayme Salsman, Deniz Top, Christopher Barry, Roy Duncan   +3 more
doaj   +1 more source

Calcium release through P2X4 activates calmodulin to promote endolysosomal membrane fusion [PDF]

, 2015
Intra-endolysosomal Ca(2+) release is required for endolysosomal membrane fusion with intracellular organelles. However, the molecular mechanisms for intra-endolysosomal Ca(2+) release and the downstream Ca(2+) targets involved in the fusion remain ...
Baars, Bakker, Brandhorst, Calcraft, Cang, Cao, Chen, Cheng, Christensen, Clarke, Coddou, Colombo, Cong, Dong, Dong, Dong, Efe, Graves, Grimm, Guo, Hay, Huang, Huynh, Khakh, Lange, Lin-Moshier, Lloyd-Evans, Luzio, Luzio, Martinez, Michael X. Zhu, Miklavc, Moreau, Morgan, Nielsen, Ogunbayo, Parkinson, Peri, Peters, Piper, Pittman, Poole, Pryor, Qi Cao, Quetglas, Qureshi, Rong, Ruas, Rudge, Ruth Murrell-Lagnado, Saftig, Samie, Schieder, Shen, Shen, Silberberg, Stoop, Sumoza-Toledo, Tapper, Treusch, Tsuboi, van den Berghe, Vergarajauregui, Wang, Ward, Weinert, Xi Zoë Zhong, Xia, Xian-Ping Dong, Yuanjie Zou, Zhao   +70 more
core   +1 more source

Fusion of isolated myoblast plasma membranes [PDF]

, 1978
Fusion of plasma membranes isolated from myoblasts grown in culture has been investigated. 1. 1. Membrane fusion was specifically dependent on Ca2+ at physiological concentrations. However, at higher concentrations of cations, fusion could be triggered
Ahkong, Batzri, Berl, Berlin, Burwen, Croce, Dahl, Dahl, Dahl, De Camilli, Douglas, Dreifuss, Fairbanks, Gratzl, Gratzl, Gratzl, Hauser, Holtzer, Kalderon, Kantor, Kent, Lawson, Lee, Maeda, Martin, Okada, Okada, Onishi, Orci, Pagano, Papahadjopoulos, Papahadjopoulos, Papahadjopoulos, Papahadjopoulos, Pauli, Peretz, Poole, Poste, Prives, Rash, Reed, Reeves, Sanger, Satir, Schimmel, Schlessinger, Schudt, Schudt, Schudt, Schudt, Shainberg, Shainberg, Van den Bosch, Van den Bosch, Van den Bosch, Vos, Weidekamm, Weidekamm, Yanofsky, Zakai   +59 more
core   +1 more source

Membrane tension and membrane fusion [PDF]

Current Opinion in Structural Biology, 2015
Diverse cell biological processes that involve shaping and remodeling of cell membranes are regulated by membrane lateral tension. Here we focus on the role of tension in driving membrane fusion. We discuss the physics of membrane tension, forces that can generate the tension in plasma membrane of a cell, and the hypothesis that tension powers ...
Michael M, Kozlov, Leonid V, Chernomordik   +1 more
openaire   +2 more sources

Fusion of neurohypophyseal membranes in vitro [PDF]

, 1977
Freeze cleaving electron microscopy has shown that fusion of isolated secretory vesicles from bovine neurohypophyses was induced by Ca 2+ in micromolar concentrations. Mg 2+ and Sr 2+ were ineffective. Mg 2+ inhibited Ca 2+-induced fusion. In suspensions
Dahl, G., Gratzl, Manfred, Russell, J. T., Thorn, N. A.   +3 more
core   +1 more source