Results 1 to 10 of about 76,537 (156)

Calcium current inactivation rather than pool depletion explains reduced exocytotic rate with prolonged stimulation in insulin-secreting INS-1 832/13 cells.

PLoS ONE, 2014
Impairment in beta-cell exocytosis is associated with reduced insulin secretion and diabetes. Here we aimed to investigate the dynamics of Ca2+-dependent insulin exocytosis with respect to pool depletion and Ca2+-current inactivation.
Morten Gram Pedersen, Vishal Ashok Salunkhe, Emma Svedin, Anna Edlund, Lena Eliasson   +4 more
doaj   +1 more source

Lytic granule exocytosis at immune synapses: lessons from neuronal synapses

Frontiers in Immunology, 2023
Regulated exocytosis is a central mechanism of cellular communication. It is not only the basis for neurotransmission and hormone release, but also plays an important role in the immune system for the release of cytokines and cytotoxic molecules.
Hsin-Fang Chang, Claudia Schirra, Varsha Pattu, Elmar Krause, Ute Becherer   +4 more
doaj   +1 more source

Human pancreatic islet miRNA-mRNA networks of altered miRNAs due to glycemic status

iScience, 2022
Summary: MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression via mRNA targeting, playing important roles in the pancreatic islets. We aimed to identify molecular pathways and genomic regulatory regions associated with altered miRNA
Alexandros Karagiannopoulos, Jonathan L.S. Esguerra, Morten G. Pedersen, Anna Wendt, Rashmi B. Prasad, Lena Eliasson   +5 more
doaj   +1 more source

Rabphilin-3A negatively regulates neuropeptide release, through its SNAP25 interaction

eLife
Neuropeptides and neurotrophins are stored in and released from dense core vesicles (DCVs). While DCVs and synaptic vesicles (SVs) share fundamental SNARE/SM proteins for exocytosis, a detailed understanding of DCV exocytosis remains elusive. We recently
Adlin Abramian, Rein I Hoogstraaten, Fiona H Murphy, Kathryn F McDaniel, Ruud F Toonen, Matthijs Verhage   +5 more
doaj   +1 more source

Inhibitors of synaptic vesicle exocytosis reduce surface expression of postsynaptic glutamate receptors

Animal Cells and Systems, 2020
Bafilomycin A1, a vacuolar H+-ATPase inhibitor, and botulinum toxin B and tetanus toxin, both vesicle fusion inhibitors, are widely known exocytosis blockers that have been used to inhibit the presynaptic release of neurotransmitters.
Dong Ho Woo, Young-Na Hur, Minwoo Wendy Jang, C. Justin Lee, Mikyoung Park   +4 more
doaj   +1 more source

Plasma membrane phosphatidylinositol (4,5)-bisphosphate promotes Weibel–Palade body exocytosis

Life Science Alliance, 2020
Phosphatidylinositol (4,5)-bisphosphate transiently accumulates at sites of Weibel–Palade body–plasma membrane fusion and promotes agonist-evoked exocytosis of endothelial von-Willebrand factor.
Tu Thi Ngoc Nguyen, Sophia N Koerdt, Volker Gerke   +2 more
doaj   +1 more source

Tracing the STING exocytosis pathway during herpes viruses infection

mBio
The STimulator of INterferon Genes (STING) constitutes a major DNA-sensing pathway that restricts HSV-1 infection in different models by activating type I interferon and pro-inflammatory responses.
Christos Dogrammatzis, Rabina Saud, Hope Waisner, Sarah Lasnier, Sreenath Muraleedharan Suma, Brandon Grieshaber, Maria Kalamvoki   +6 more
doaj   +1 more source

An isoform-specific function of Cdc42 in regulating mammalian Exo70 during axon formation

Life Science Alliance, 2023
The brain-specific isoform of the GTPase Cdc42 is shown to promote axon formation by interacting with the exocyst tethering complex and increasing exocytosis downstream of its activator Arhgef7. The highly conserved GTPase Cdc42 is an essential regulator
Priyadarshini Ravindran, Andreas W Püschel   +1 more
doaj   +1 more source

36 h fasting of young men influences adipose tissue DNA methylation of LEP and ADIPOQ in a birth weight-dependent manner

Clinical Epigenetics, 2017
Background Subjects born with low birth weight (LBW) display a more energy-conserving response to fasting compared with normal birth weight (NBW) subjects.
Line Hjort, Sine W. Jørgensen, Linn Gillberg, Elin Hall, Charlotte Brøns, Jan Frystyk, Allan A. Vaag, Charlotte Ling   +7 more
doaj   +1 more source

tPA‐GFP is a reliable probe for detecting compound exocytosis in human pancreatic β‐cells

FASEB BioAdvances
Pancreatic β‐cells secrete insulin stored in large dense core vesicles (LDCV) by fusion of vesicle and plasma membrane during a process called insulin exocytosis.
Aishwarya A. Makam, Shruti Sharma, Prajwal Nagle, Nandhini M. Sundaram, Vidya Mangala Prasad, Nikhil R. Gandasi   +5 more
doaj   +1 more source