Results 1 to 10 of about 99,750 (290)
A primordial synaptotagmin-independent function of complexin in regulated exocytosis [PDF]
Nature CommunicationsIn Ca²⁺-triggered exocytosis such as synaptic neurotransmitter release, vesicle fusion is tightly regulated by synaptotagmin (Syt) and complexin (Cpx), which together clamp partially assembled SNARE complexes to prevent premature fusion.
Xu Chen +6 more
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Impaired Regulated Exocytosis and GLUT4 Trafficking in Dysferlin-Deficient Human Myoblasts: A Pilot Study [PDF]
BiomedicinesBackground/Objectives: Dysferlinopathies are inherited muscular dystrophies caused by DYSF mutations that lead to progressive muscle degeneration. Proteomic analyses of patient muscle reveal altered abundance of proteins involved in regulated exocytosis ...
María José Guerra-Fernández +8 more
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Spatiotemporal dynamics of signal dependent exocytosis and parasitophorous vacuolar membrane rupture during Plasmodium falciparum egress. [PDF]
PLoS PathogensMalaria, caused by intracellular Plasmodium falciparum parasites, remains a major global health concern. These parasites reside and replicate within a vacuole in host red blood cells. Egress of daughter parasites out of the vacuolar and host membranes is
Watcharatip Dedkhad +4 more
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Exocytosed ATP as a therapeutic target for inflammatory and metabolic diseases [PDF]
Frontiers in PharmacologyExtracellular adenosine triphosphate (eATP) is a key intercellular signaling molecule in purinergic transmission and contributes to pain, inflammation, and tissue dysfunction in a wide range of diseases. Although eATP is released through membrane damage,
Nao Hasuzawa +4 more
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iScience, 2023 Summary: Glucocorticoid use is associated with steroid-induced diabetes mellitus and impaired pancreatic β-cell insulin secretion. Here, the glucocorticoid-mediated transcriptomic changes in human pancreatic islets and the human insulin-secreting EndoC ...
Alexandros Karagiannopoulos +5 more
doaj +1 more source
MARCKS protein is phosphorylated and regulates calcium mobilization during human acrosomal exocytosis. [PDF]
PLoS ONE, 2013 Acrosomal exocytosis is a calcium-regulated exocytosis that can be triggered by PKC activators. The involvement of PKC in acrosomal exocytosis has not been fully elucidated, and it is unknown if MARCKS, the major substrate for PKC, participates in this ...
Marcelo J Rodriguez Peña +4 more
doaj +1 more source
Frontiers in Molecular Neuroscience, 2021 Streams of action potentials or long depolarizations evoke a massive exocytosis of transmitters and peptides from the surface of dendrites, axons and cell bodies of different neuron types.
Francisco F. De-Miguel +13 more
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Glucocorticoid induces human beta cell dysfunction by involving riborepressor GAS5 LincRNA
Molecular Metabolism, 2020 Objective: A widely recognized metabolic side effect of glucocorticoid (GC) therapy is steroid-induced diabetes mellitus (DM). However, studies on the molecular basis of GC-induced pancreatic beta cell dysfunction in human beta cells are lacking.
Jonathan L.S. Esguerra +8 more
doaj +1 more source
eLife, 2016 The hormones insulin and glucagon both play important roles in the development of diabetes.
Lena Eliasson, Anna Wendt
doaj +1 more source
EBioMedicine, 2016 Statins are beneficial in the treatment of cardiovascular disease (CVD), but these lipid-lowering drugs are associated with increased incidence of new on-set diabetes.
Vishal A. Salunkhe +9 more
doaj +1 more source