Results 1 to 10 of about 151,391 (333)
iScience, 2023 Summary: Glucocorticoid use is associated with steroid-induced diabetes mellitus and impaired pancreatic β-cell insulin secretion. Here, the glucocorticoid-mediated transcriptomic changes in human pancreatic islets and the human insulin-secreting EndoC ...
Alexandros Karagiannopoulos +5 more
doaj +1 more source
Release of vasopressin from isolated permeabilized neurosecretory nerve terminals is blocked by the light chain of botulinum A toxin [PDF]
, 1990 The intracellular action on exocytosis of botulinim A toxin and constituent chains was studied using permeabilized isolated nerve endings from the rat neural lobe. The release of the neuropeptide vasopressin was measured by radioimmunoassay.
Dayanithi, G. +4 more
core +6 more sources
MARCKS protein is phosphorylated and regulates calcium mobilization during human acrosomal exocytosis. [PDF]
PLoS ONE, 2013 Acrosomal exocytosis is a calcium-regulated exocytosis that can be triggered by PKC activators. The involvement of PKC in acrosomal exocytosis has not been fully elucidated, and it is unknown if MARCKS, the major substrate for PKC, participates in this ...
Marcelo J Rodriguez Peña +4 more
doaj +1 more source
Frontiers in Molecular Neuroscience, 2021 Streams of action potentials or long depolarizations evoke a massive exocytosis of transmitters and peptides from the surface of dendrites, axons and cell bodies of different neuron types.
Francisco F. De-Miguel +13 more
doaj +1 more source
Glucocorticoid induces human beta cell dysfunction by involving riborepressor GAS5 LincRNA
Molecular Metabolism, 2020 Objective: A widely recognized metabolic side effect of glucocorticoid (GC) therapy is steroid-induced diabetes mellitus (DM). However, studies on the molecular basis of GC-induced pancreatic beta cell dysfunction in human beta cells are lacking.
Jonathan L.S. Esguerra +8 more
doaj +1 more source
eLife, 2016 The hormones insulin and glucagon both play important roles in the development of diabetes.
Lena Eliasson, Anna Wendt
doaj +1 more source
Nucleotide-, chemotactic peptide- and phorbol ester-induced exocytosis in HL-60 leukemic cells [PDF]
, 1990 Undifferentiated and differentiated HL-60 leukemic cells possess nucleotide receptors which functionally couple to phospholipase C via pertussis toxin-sensitive guanine nucleotide-binding proteins (G-proteins).
Seifert, Roland +1 more
core +1 more source
EBioMedicine, 2016 Statins are beneficial in the treatment of cardiovascular disease (CVD), but these lipid-lowering drugs are associated with increased incidence of new on-set diabetes.
Vishal A. Salunkhe +9 more
doaj +1 more source
Journal of Nanobiotechnology, 2021 Background Polyamidoamine (PAMAM) dendrimer applications have extended from tumor cells to multidrug-resistant tumor cells. However, their transportation in multidrug-resistant tumor cells remains unclear.
Jie Zhang +7 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2023 Before fertilization, spermatozoa must undergo calcium-regulated acrosome exocytosis in response to physiological stimuli such as progesterone and zona pellucida.
Cintia C. Vaquer +10 more
doaj +1 more source