Results 1 to 10 of about 465,747 (346)
The Effects of Serotonin in Immune Cells
Frontiers in Cardiovascular Medicine, 2017 Serotonin [5-hydroxytryptamine (5-HT)] plays an important role in many organs as a peripheral hormone. Most of the body’s serotonin is circulating in the bloodstream, transported by blood platelets and is released upon activation.
Daniel Duerschmied
exaly +4 more sources
Serotonin reduction in post-acute sequelae of viral infection
Cell, 2023 SUMMARY Post-acute sequelae of COVID-19 (PASC, “Long COVID”) pose a significant global health challenge. The pathophysiology is unknown, and no effective treatments have been found to date.
Una O'Doherty +2 more
exaly +2 more sources
Crystal Structure of an LSD-Bound Human Serotonin Receptor
Cell, 2017 SUMMARY The prototypical hallucinogen LSD acts via serotonin receptors, and here we describe the crystal structure of LSD in complex with the human serotonin receptor 5-HT2B. The complex reveals conformational rearrangements to accommodate LSD, providing
Robin Betz, John McCorvy, Bryan Roth
exaly +2 more sources
Serotonin syndrome: a clinical review of current controversies [PDF]
Journal of Integrative Neuroscience, 2020 Serotonin syndrome is a state of increased central and peripheral serotonin (5-hydroxytryptamine) activity. Unless recognized and treated early, serotonin syndrome can lead to seizures, shock and death.
Ursula Werneke +3 more
doaj +1 more source
Clinical pharmacology and therapy, 2023 Serotonin reuptake inhibitor antidepressants, including selective serotonin reuptake inhibitors (SSRIs; i.e., citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, and sertraline), serotonin and norepinephrine reuptake inhibitors (i.e ...
C. Bousman +17 more
semanticscholar +1 more source
The serotonin theory of depression: a systematic umbrella review of the evidence
Molecular Psychiatry, 2022 The serotonin hypothesis of depression is still influential. We aimed to synthesise and evaluate evidence on whether depression is associated with lowered serotonin concentration or activity in a systematic umbrella review of the principal relevant areas
J. Moncrieff +5 more
semanticscholar +1 more source
International Journal of Molecular Sciences, 2022 Depression is a common and serious disorder, characterized by symptoms like anhedonia, lack of energy, sad mood, low appetite, and sleep disturbances.
A. S. Correia, N. Vale
semanticscholar +1 more source
Plasma Serotonin and Cardiovascular Outcomes in Chronic Kidney Disease
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023 Background Platelet‐poor plasma serotonin levels are associated with adverse cardiovascular outcomes. Although plasma serotonin levels increase in chronic kidney disease, the cardiovascular implications remain unknown.
Daniel Edmonston +2 more
doaj +1 more source
Selective Serotonin Reuptake Inhibitors and Adverse Effects: A Narrative Review
Neurology International, 2021 Depression is the most prevalent psychiatric disorder in the world, affecting 4.4% of the global population. Despite an array of treatment modalities, depressive disorders remain difficult to manage due to many factors. Beginning with the introduction of
Amber N. Edinoff +11 more
semanticscholar +1 more source
Cell Host and Microbe, 2022 Diarrhea-predominant irritable bowel syndrome (IBS-D), a globally prevalent functional gastrointestinal (GI) disorder, is associated with elevated serotonin that increases gut motility.
L. Zhai +20 more
semanticscholar +1 more source