Results 1 to 10 of about 77,943 (311)
Triptans and CGRP blockade – impact on the cranial vasculature [PDF]
The Journal of Headache and Pain, 2017 The trigeminovascular system plays a key role in the pathophysiology of migraine. The activation of the trigeminovascular system causes release of various neurotransmitters and neuropeptides, including serotonin and calcitonin gene-related peptide (CGRP),
Silvia Benemei +9 more
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Ergotamine enhances circadian amplitude and diurnally mitigates nitroglycerin-induced mechanical hypersensitivity [PDF]
The Journal of Headache and PainBackground Cluster headache and migraine have a circadian timing of attacks and are linked to the trigeminovascular system. Recently the trigeminal ganglion was found to have a strong circadian rhythm, with the serotonin 2A receptor identified as a clock-
Chorong Han +8 more
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The Role of Serotonin in Breast Cancer Stem Cells
Molecules, 2021 Breast tumors were the first tumors of epithelial origin shown to follow the cancer stem cell model. The model proposes that cancer stem cells are uniquely endowed with tumorigenic capacity and that their aberrant differentiation yields non-tumorigenic ...
William D. Gwynne +3 more
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Effects of Ramosetron on Nausea and Vomiting Following Spinal Surgery: A Meta-Analysis
Current Therapeutic Research, 2022 : Background: Spinal surgery is associated with severe pain within the first few days after surgery. Opioids are commonly used to control postoperative pain, but these can lead to postoperative nausea and vomiting (PONV).
Yiyun Lin, MD +4 more
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Biomolecules, 2023 Serotonin (5-HT) plays an important role in the regulation of several basic functions of the central and peripheral nervous system. Among the 5-HT receptors, serotonin-6 (5-HT6) receptor has been an area of substantial research.
Ramakrishna Nirogi +9 more
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Serotonin drives a novel GABAergic synaptic current recorded in rat cerebellar purkinje cells: a lugaro cell to purkinje cell synapse [PDF]
, 2003 We recorded a novel fast GABAergic synaptic current in cerebellar Purkinje cells in rat brain slices using patch-clamp techniques. Because of a relatively low sensitivity to bicuculline, these currents can be recorded under conditions in which basket and
Dean, I., Edwards, F.A., Robertson, S.J.
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Management of chemotherapy induced emesis [PDF]
Archive of Oncology, 2004 Important progress has been achieved in the last few years in the prevention of chemotherapy-induced nausea and vomiting thanks to the introduction in clinical practice first of the 5-HT3 antagonists and of the NK1 antagonists more recently.
Roila Fausto
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The antidepressant 5-HT2A receptor antagonists pizotifen and cyproheptadine inhibit serotonin-enhanced platelet function. [PDF]
PLoS ONE, 2014 There is considerable interest in defining new agents or targets for antithrombotic purposes. The 5-HT2A receptor is a G-protein coupled receptor (GPCR) expressed on many cell types, and a known therapeutic target for many disease states.
Olivia A Lin +4 more
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JIIS: Jurnal Ilmiah Ibnu Sina, 2021 Depression is a psychiatric disorder characterized by decreased mood and affects daily activities.The development of herbal ingredients as complementary therapy becomes increasing in line with the number of patients who avoid side effects in ...
Ridho Islamie +4 more
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Pharmaceuticals, 2022 The enzyme monoamine oxidase A (MAOA) catalyzes the degradation of several neurotransmitters, including serotonin. A large body of evidence has shown that genetic MAOA deficiency predisposes humans and mice to aggression and antisocial behavior.
Roberto Frau +4 more
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