Results 1 to 10 of about 43,328 (214)
Antagonists of the serotonin receptor 5A target human breast tumor initiating cells [PDF]
BMC Cancer, 2020 Background Breast tumor initiating cells (BTIC) are stem-like cells that initiate and sustain tumor growth, and drive disease recurrence. Identifying therapies targeting BTIC has been hindered due primarily to their scarcity in tumors.
William D. Gwynne +9 more
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The Role of Serotonin in Breast Cancer Stem Cells
Molecules, 2021 Breast tumors were the first tumors of epithelial origin shown to follow the cancer stem cell model. The model proposes that cancer stem cells are uniquely endowed with tumorigenic capacity and that their aberrant differentiation yields non-tumorigenic ...
William D. Gwynne +3 more
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Quantitative Structure-Activity Relationship Study on Tetrahydro-β-carboline Antagonists of the Serotonin 2B (5HT 2B) Contractile Receptor in the Rat Stomach Fundus [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2001 Pankaj Kumar Singh, Rajesh Kumar
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Effects of Ramosetron on Nausea and Vomiting Following Spinal Surgery: A Meta-Analysis
Current Therapeutic Research, 2022 : Background: Spinal surgery is associated with severe pain within the first few days after surgery. Opioids are commonly used to control postoperative pain, but these can lead to postoperative nausea and vomiting (PONV).
Yiyun Lin, MD +4 more
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Biomolecules, 2023 Serotonin (5-HT) plays an important role in the regulation of several basic functions of the central and peripheral nervous system. Among the 5-HT receptors, serotonin-6 (5-HT6) receptor has been an area of substantial research.
Ramakrishna Nirogi +9 more
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Management of chemotherapy induced emesis [PDF]
Archive of Oncology, 2004 Important progress has been achieved in the last few years in the prevention of chemotherapy-induced nausea and vomiting thanks to the introduction in clinical practice first of the 5-HT3 antagonists and of the NK1 antagonists more recently.
Roila Fausto
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The antidepressant 5-HT2A receptor antagonists pizotifen and cyproheptadine inhibit serotonin-enhanced platelet function. [PDF]
PLoS ONE, 2014 There is considerable interest in defining new agents or targets for antithrombotic purposes. The 5-HT2A receptor is a G-protein coupled receptor (GPCR) expressed on many cell types, and a known therapeutic target for many disease states.
Olivia A Lin +4 more
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JIIS: Jurnal Ilmiah Ibnu Sina, 2021 Depression is a psychiatric disorder characterized by decreased mood and affects daily activities.The development of herbal ingredients as complementary therapy becomes increasing in line with the number of patients who avoid side effects in ...
Ridho Islamie +4 more
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Pharmaceuticals, 2022 The enzyme monoamine oxidase A (MAOA) catalyzes the degradation of several neurotransmitters, including serotonin. A large body of evidence has shown that genetic MAOA deficiency predisposes humans and mice to aggression and antisocial behavior.
Roberto Frau +4 more
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Frontiers in Molecular Neuroscience, 2020 A number of studies implicate biogenic amines in regulating circadian rhythms. In particular, dopamine and serotonin influence the entrainment of circadian rhythms to daily food availability.
Christian M. Gallardo +2 more
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