Results 11 to 20 of about 235,344 (293)

Azologization of serotonin 5-HT3 receptor antagonists [PDF]

Beilstein Journal of Organic Chemistry, 2019
The serotonin 5-hydroxytryptamine 3 receptor (5-HT3R) plays a unique role within the seven classes of the serotonin receptor family, as it represents the only ionotropic receptor, while the other six members are G protein-coupled receptors (GPCRs). The 5-
Karin Rustler, Galyna Maleeva, Piotr Bregestovski, Burkhard König   +3 more
doaj   +2 more sources

Serotonin reuptake inhibitors and cardiovascular disease [PDF]

, 2005
Selective serotonin re-uptake inhibiting drugs (SSRIs) are widely used for endogenous depression. In addition to depleting the nerve terminals of serotonin they also lower blood platelet serotonin levels.
Noble, M., Drake-Holland, A.J., Belcher, P.R.   +2 more
core   +9 more sources

Serotonin induced hepatic steatosis is associated with modulation of autophagy and notch signaling pathway

Cell Communication and Signaling, 2018
Background Besides its neurotransmitter and vasoconstriction functions, serotonin is an important mediator of numerous biological processes in peripheral tissues including cell proliferation, steatosis, and fibrogenesis.
Suryakant Niture, Maxwell A. Gyamfi, Habib Kedir, Elena Arthur, Habtom Ressom, Gagan Deep, Deepak Kumar   +6 more
doaj   +2 more sources

Serotonin (5-HT3) receptor antagonists for the reduction of symptoms of low anterior resection syndrome

Clinical and Experimental Gastroenterology, 2014
Ryohei Itagaki, Keiji Koda, Masato Yamazaki, Kiyohiko Shuto, Chihiro Kosugi, Atsushi Hirano, Hidehito Arimitsu, Risa Shiragami, Yukino Yoshimura, Masato Suzuki Department of Surgery, Teikyo University Chiba Medical Center, Anesaki, Ichihara, Chiba, Japan
Itagaki R, Koda K, Yamazaki M, Shuto K, Kosugi C, Hirano A, Arimitsu H, Shiragami R, Yoshimura Y, Suzuki M   +8 more
doaj   +1 more source

The Effects of Serotonin Receptor Antagonists on Contraction and Relaxation Responses Induced by Electrical Stimulation in the Rat Small Intestine [PDF]

, 2014
Background: The main source of 5-HT in body is in enterchromafin cells of intestine, different studies mentioned different roles for endogenous 5-HT and receptors involved and it is not clearified the mechanism of action of endogenous 5-HT. Objectives:
Javid, Farideh A., Mashhadi, Farzaneh Farajian, Naylor, Robert J.   +2 more
core   +5 more sources

Sustained Exposure to 3,4-Methylenedioxymethamphetamine Induces the Augmentation of Exocytotic Serotonin Release in Rat Organotypic Raphe Slice Cultures

Journal of Pharmacological Sciences, 2010
3,4-Methylenedioxymethamphetamine (MDMA) causes serotonin efflux via serotonin transporter. Recently, we have reported that sustained exposure to MDMA induced an augmentation of serotonin release in rat raphe serotonergic slice cultures.
Kazuki Nagayasu, Maiko Kitaichi, Hisashi Shirakawa, Takayuki Nakagawa, Shuji Kaneko   +4 more
doaj   +1 more source

Analysis of the package inserts of migraine prophylactics

Headache Medicine, 2010
Introduction: The use of migraine prophylactics is based on clinical evidence and the personal experience of those who prescribe them. Medicines commonly indicated for other diseases are used and they do not have any recommendation for preventing ...
Raimundo Pereira da Silva Neto, Jerlene Maria de Sousa Barbosa, Kelson James Almeida   +2 more
doaj   +1 more source

Role of Biogenic Amines in Oviposition by the Diamondback Moth, Plutella xylostella L

Frontiers in Physiology, 2020
Oviposition is an important reproductive behavior that is triggered by mating in insects, and biogenic amines might be involved in its regulation. The effects of biogenic amines on oviposition have only been studied in a few insect species, and the ...
Fan Li, Ke Li, Li-Juan Wu, Yong-Liang Fan, Tong-Xian Liu   +4 more
doaj   +1 more source

Methiothepin Suppresses Human Ovarian Cancer Cell Growth by Repressing Mitochondrion-Mediated Metabolism and Inhibiting Angiogenesis In Vivo

Pharmaceutics, 2020
Ovarian cancer is the fifth leading cause of cancer-related deaths in women. Despite treatment, most patients experience relapse and the 5-year survival rate of ovarian cancer is less than 50%.
Jin-Young Lee, Changwon Yang, Whasun Lim, Gwonhwa Song   +3 more
doaj   +1 more source

Cannabidiol Regulates Long Term Potentiation Following Status Epilepticus: Mediation by Calcium Stores and Serotonin

Frontiers in Molecular Neuroscience, 2018
Epilepsy is a devastating disease, with cognitive and emotional consequences that are not curable. In recent years, it became apparent that cannabinoids help patients to cope with epilepsy.
Nicola Maggio, Nicola Maggio, Nicola Maggio, Efrat Shavit Stein, Menahem Segal   +4 more
doaj   +1 more source