Results 11 to 20 of about 44,540 (313)

Azologization of serotonin 5-HT3 receptor antagonists [PDF]

Beilstein Journal of Organic Chemistry, 2019
The serotonin 5-hydroxytryptamine 3 receptor (5-HT3R) plays a unique role within the seven classes of the serotonin receptor family, as it represents the only ionotropic receptor, while the other six members are G protein-coupled receptors (GPCRs). The 5-
Karin Rustler, Galyna Maleeva, Piotr Bregestovski, Burkhard König   +3 more
doaj   +2 more sources

Serotonin (5-HT3) receptor antagonists for the reduction of symptoms of low anterior resection syndrome

Clinical and Experimental Gastroenterology, 2014
Ryohei Itagaki, Keiji Koda, Masato Yamazaki, Kiyohiko Shuto, Chihiro Kosugi, Atsushi Hirano, Hidehito Arimitsu, Risa Shiragami, Yukino Yoshimura, Masato Suzuki Department of Surgery, Teikyo University Chiba Medical Center, Anesaki, Ichihara, Chiba, Japan
Itagaki R, Koda K, Yamazaki M, Shuto K, Kosugi C, Hirano A, Arimitsu H, Shiragami R, Yoshimura Y, Suzuki M   +8 more
doaj   +1 more source

Enhanced sensitivity of postsynaptic serotonin-1A receptors in rats and mice with high trait aggression [PDF]

, 2001
Individual differences in aggressive behaviour have been linked to variability in central serotonergic activity, both in humans and animals. A previous experiment in mice, selectively bred for high or low levels of aggression, showed an up-regulation of ...
Buwalda, Bauke, Vegt, Bea J. van der,, van der Vegt, BJ, Ruiter, Anne J.H. de,, Jong, Jelly G. de,, Koolhaas, J.M., de Ruiter, Anne J.H., Bauke Buwalda, Sietse F de Boer, Koolhaas, Jaap M.,, van der Vegt, Bea J., de Jong, Jelly G., Koolhaas, JM, de Boer, SF, de Jong, JG, Buwalda, Bauke,, Buwalda, B, Bea J van der Vegt, Boer, Sietse F. de,, Anne J.H de Ruiter, Jelly G de Jong, de Boer, Sietse F., Jaap M Koolhaas, de Ruiter, AJH   +23 more
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Serotonin induced hepatic steatosis is associated with modulation of autophagy and notch signaling pathway

Cell Communication and Signaling, 2018
Background Besides its neurotransmitter and vasoconstriction functions, serotonin is an important mediator of numerous biological processes in peripheral tissues including cell proliferation, steatosis, and fibrogenesis.
Suryakant Niture, Maxwell A. Gyamfi, Habib Kedir, Elena Arthur, Habtom Ressom, Gagan Deep, Deepak Kumar   +6 more
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Role of Biogenic Amines in Oviposition by the Diamondback Moth, Plutella xylostella L

Frontiers in Physiology, 2020
Oviposition is an important reproductive behavior that is triggered by mating in insects, and biogenic amines might be involved in its regulation. The effects of biogenic amines on oviposition have only been studied in a few insect species, and the ...
Fan Li, Ke Li, Li-Juan Wu, Yong-Liang Fan, Tong-Xian Liu   +4 more
doaj   +1 more source

5-hydroxytryptamine (5-HT) cellular sequestration during chronic exposure delays 5-HT₃ receptor resensitization due to Its subsequent release [PDF]

, 2014
The serotonergic synapse is dynamically regulated by serotonin (5-hydroxytryptamine (5-HT)) with elevated levels leading to the down-regulation of the serotonin transporter and a variety of 5-HT receptors, including the 5-HT type-3 (5-HT3) receptors.
Moffat, Christopher, Bollan, Karen A., Connolly, Christopher N., Samson, Andrew J., Alexander, Amy, Hothersall, J. Daniel   +5 more
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Molecular and pharmacological characterization of serotonin 5-HT2α and 5-HT7 receptors in the salivary glands of the blowfly calliphora vicina [PDF]

, 2012
Secretion in blowfly (Calliphora vicina) salivary glands is stimulated by the biogenic amine serotonin (5-hydroxytryptamine, 5-HT), which activates both inositol 1,4,5-trisphosphate (InsP3)/Ca2+ and cyclic adenosine 3′,5′-monophosphate (cAMP) signalling ...
Walz, Bernd, Bernd Walz, Baumann, Otto, Claudia Röser, Nadine Jordan (120821), Röser,C., Bernd Walz (48845), Wolfgang Blenau, Balfanz, Sabine, Otto Baumann (48844), Blenau, Wolfgang, Baumann, A., Sabine Balfanz (120824), Jordan, Nadine, Baumann, Arnd, Sabine Balfanz, Arnd Baumann, Blenau, Wolfgang (Dr.), Claudia Röser (120818), Wolfgang Blenau (120829), Nadine Jordan, Otto Baumann, Röser, Claudia, Arnd Baumann (120826)   +23 more
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Inhibition of native 5-HT3 receptor-evoked contractions in Guinea pig and mouse ileum by antimalarial drugs [PDF]

, 2014
Quinine, Chloroquine and mefloquine are commonly used to treat malaria; however with associated gastrointestinal (GI) side-effects. These drugs act as antagonists at recombinant 5-HT3 receptors and modulate gut peristalsis.
Walsh, Jacqueline M., Muhdar, Simerjyot, Walsh, Jacqueline, Wildman, Scott S.P., Wildman, Scott S., Barrett, Iain D., Adel-Aziz, Mohammed, Kelley, Stephen P., Wildman, Scott, Kelly, Mark C.   +9 more
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Methiothepin Suppresses Human Ovarian Cancer Cell Growth by Repressing Mitochondrion-Mediated Metabolism and Inhibiting Angiogenesis In Vivo

Pharmaceutics, 2020
Ovarian cancer is the fifth leading cause of cancer-related deaths in women. Despite treatment, most patients experience relapse and the 5-year survival rate of ovarian cancer is less than 50%.
Jin-Young Lee, Changwon Yang, Whasun Lim, Gwonhwa Song   +3 more
doaj   +1 more source

Cannabidiol Regulates Long Term Potentiation Following Status Epilepticus: Mediation by Calcium Stores and Serotonin

Frontiers in Molecular Neuroscience, 2018
Epilepsy is a devastating disease, with cognitive and emotional consequences that are not curable. In recent years, it became apparent that cannabinoids help patients to cope with epilepsy.
Nicola Maggio, Nicola Maggio, Nicola Maggio, Efrat Shavit Stein, Menahem Segal   +4 more
doaj   +1 more source