Results 1 to 10 of about 4,160 (205)

Anxiolytic-like effects of Pseudospondias microcarpa hydroethanolic leaf extract in zebrafish: Possible involvement of GABAergic and serotonergic pathways [PDF]

Natural Products and Bioprospecting, 2023
Pseudospondias microcarpa is used in ethnomedicine to manage central nervous system diseases. The hydroethanolic extract (PME) from the leaves of the plant has shown anxiolytic-like properties in mice anxiety models.
Donatus Wewura Adongo, Charles Kwaku Benneh, Augustine Tandoh, Robert Peter Biney, Kennedy Kwami Edem Kukuia, Priscilla Kolibea Mante, Benjamin Kingsley Harley, David Oteng, Emmanuel Aduboffour Appiah, Ernest Cudjoe Anorbor, Eric Woode   +10 more
doaj   +2 more sources

Cleomin Exerts Acute Antinociceptive Effects in Mice via GABA_B and Muscarinic Receptors [PDF]

Pharmaceuticals, 2023
Cleomin, a 1,3-oxazolidine-2-thione, was recently isolated from Neocalyptrocalyx longifolium, a species traditionally used for treating painful conditions. Reports about the pharmacological activities of cleomin are lacking.
Luíza Carolina França Opretzka, Max Denisson Maurício Viana, Alyne Almeida de Lima, Thalisson Amorim de Souza, Marcus Tullius Scotti, Josean Fechine Tavares, Marcelo Sobral da Silva, Milena Botelho Pereira Soares, Cristiane Flora Villarreal   +8 more
doaj   +2 more sources

Methysergide and Infantile Spasms

Pediatric Neurology Briefs, 1989
A trial of antiadrenergic and antiseretonergic drugs in the treatment of 24 newly diagnosed and previously untreated infantile spasm patients is reported from the Epilepsy Research Center, Section of Neurophysiology, Department of Neurology, Baylor ...
J Gordon Millichap
doaj   +1 more source

Antinociception induced by stimulating amygdaloid nuclei in rats: changes produced by systemically administered antagonists

Brazilian Journal of Medical and Biological Research, 1998
The antinociceptive effects of stimulating the medial (ME) and central (CE) nuclei of the amygdala in rats were evaluated by the changes in the latency for the tail withdrawal reflex to noxious heating of the skin.
M.A. Oliveira, W.A. Prado
doaj   +1 more source

Analgesic Effect of SH003 and Trichosanthes kirilowii Maximowicz in Paclitaxel-Induced Neuropathic Pain in Mice

Current Issues in Molecular Biology, 2022
Pacliatxel is a taxol-based chemotherapeutic drug that is widely used to treat cancer. However, it can also induce peripheral neuropathy, which limits its use.
Ji Hwan Lee, Bonglee Kim, Seong-Gyu Ko, Woojin Kim   +3 more
doaj   +1 more source

Involvement of serotonergic, noradrenergic and gabaergic systems in the antinociceptive effect of a ketamine-magnesium sulfate combination in acute pain

Acta Veterinaria, 2018
Ketamine and magnesium can interact in additive, supra-additive and antagonistic manners in analgesia or anesthesia. Ketamine is a non-competitive NMDA receptor antagonist.
Katarina Savić Vujović, Sonja Vučković, Radan Stojanović, Nevena Divac, Branislava Medić, Dragana Srebro, Marko Kadija, Milica Prostran   +7 more
doaj   +1 more source

Medications we miss in headache treatment in Brazil

Headache Medicine, 2017
There are some options for the treatment with drugs that are useful and desirable in clinical practice in Headache Medicine, which are no available to the Brazilian doctors, such as methysergide, intravenous indomethacin, melatonin, Petasites hybridus ...
Mario Fernando Prieto Peres, Marcelo Moraes Valença   +1 more
doaj   +1 more source

Appetite-suppressing effects and interactions of centrally administered corticotropin-releasing factor, urotensin I and serotonin in rainbow trout (Oncorhynchus mykiss)

Frontiers in Neuroscience, 2013
Corticotropin-releasing factor (CRF), urotensin I (UI) and serotonin (5-HT) are generally recognized as key regulators of the anorexigenic stress response in vertebrates, yet the proximal effects and potential interactions of these central messengers on ...
Van A. Ortega, David A. Lovejoy, Nicholas J. Bernier   +2 more
doaj   +1 more source

Serotonin receptors are involved in the spinal mediation of descending facilitation of surgical incision-induced increase of Fos-like immunoreactivity in rats

Molecular Pain, 2010
Background Descending pronociceptive pathways may be implicated in states of persistent pain. Paw skin incision is a well-established postoperative pain model that causes behavioral nociceptive responses and enhanced excitability of spinal dorsal horn ...
Prado Wiliam A, Del Bel Elaine A, Dias Quintino M, Silveira João   +3 more
doaj   +1 more source

The Tricyclic Antidepressant Clomipramine Increases Plasma Glucose Levels of Mice

Journal of Pharmacological Sciences, 2003
: Effects of the tricyclic antidepressant clomipramine on plasma glucose levels in mice were studied. Clomipramine at doses ranging 5 – 20 mg/kg elicited significant hyperglycemia in mice.
Yumi Sugimoto, Kiyo Inoue, Jun Yamada
doaj   +1 more source