Results 31 to 40 of about 4,160 (205)

Characterization of a new type of neuronal 5-HT G- protein coupled receptor in the cestode nervous system.

PLoS ONE, 2021
Cestodes are platyhelminth parasites with a wide range of hosts that cause neglected diseases. Neurotransmitter signaling is of critical importance for these parasites which lack circulatory, respiratory and digestive systems.
Federico Camicia, Hugo R Vaca, Sang-Kyu Park, Augusto E Bivona, Ariel Naidich, Matias Preza, Uriel Koziol, Ana M Celentano, Jonathan S Marchant, Mara C Rosenzvit   +9 more
doaj   +2 more sources

Involvement of serotonin and eicosanoids in the rat paw oedema response to the essential oil of Pilocarpus spicatus

Mediators of Inflammation, 1992
Subplantar injection of Pilocarpus spicatus essential oil (PSEO), induced rat hindpaw oedema in a dose-dependent manner. The time course study revealed that when compared to carrageenan-induced oedema, the oedema response to PSEO was greater at 1 h post ...
J. C. R. Silva, V. S. N. Rao
doaj   +1 more source

Methysergide induces selective potentiation in cholinergic contractions of the guinea-pig vas deferens by facilitating acetylcholine release

, 1979
Methysergide (3 times 10−6 M) enhanced the contractile responses of the isolated stripped vas deferens of guinea-pig to acetylcholine(ACh) and arecoline, but not those to noradrenaline, tyramine and bradykinin.
Takeshi Katsuragi, Tatsuo Furukawa
core   +1 more source

Effect of peripheral 5-HT on glucose and lipid metabolism in wether sheep. [PDF]

PLoS ONE, 2014
In mice, peripheral 5-HT induces an increase in the plasma concentrations of glucose, insulin and bile acids, and a decrease in plasma triglyceride, NEFA and cholesterol concentrations.
Hitoshi Watanabe, Ryo Saito, Tatsuya Nakano, Hideyuki Takahashi, Yu Takahashi, Keisuke Sumiyoshi, Katsuyoshi Sato, Xiangning Chen, Natsumi Okada, Shunsuke Iwasaki, Dian W Harjanti, Natsumi Sekiguchi, Hiroaki Sano, Haruki Kitazawa, Michael T Rose, Shyuichi Ohwada, Kouichi Watanabe, Hisashi Aso   +17 more
doaj   +1 more source

Methysergide reduces nonnutritive blood flow in normal and scalded skin

, 2000
Methysergide is a serotonin antagonist and has been demonstrated to reduce wound blood flow and edema formation. We have determined the effect of methysergide on protein kinetics in normal and scalded skin of anesthetized rabbits.l-[ ring-13C6]- orl ...
Robert R. Wolfe, Øivind Irtun, Xiao-Jun Zhang, Yaoqing Zheng   +3 more
core   +1 more source

Heterosynaptic long-term potentiation from the anterior cingulate cortex to spinal cord in adult rats

Molecular Pain, 2018
Spinal nociceptive transmission receives biphasic modulation from supraspinal structures. Recent studies demonstrate that the anterior cingulate cortex facilitates spinal excitatory synaptic transmission and nociceptive reflex.
Qi-Yu Chen, Tao Chen, Li-Jun Zhou, Xian-Guo Liu, Min Zhuo   +4 more
doaj   +1 more source

Mechanisms of Analgesic Action of Neurotropin on Chronic Pain in Adjuvant-Induced Arthritic Rat: Roles of Descending Noradrenergic and Serotonergic Systems

Journal of Pharmacological Sciences, 2005
Neurotropin®, a non-protein extract from the inflamed skin of rabbits inoculated with vaccinia virus, has been clinically used as an analgesic drug for treatment of chronic pain.
Tomoshi Miura, Ryohei Okazaki, Hiroyuki Yoshida, Hiroyoshi Namba, Hisashi Okai, Minoru Kawamura   +5 more
doaj   +1 more source

New Approaches to Shifting the Migraine Treatment Paradigm

Frontiers in Pain Research, 2022
The standard of care paradigm for migraine treatment has been based almost exclusively on approaches that grew out of the happenstance use of market pharmaceuticals.
Brian Johnson, Frederick G. Freitag
doaj   +1 more source

Pharmacological Characterization of Itch-Associated Response Induced by Repeated Application of Oxazolone in Mice

Journal of Pharmacological Sciences, 2010
We investigated pharmacological characteristics of the itch-associated response to chronic dermatitis induced by 4-ethoxymethylene-2-phenyl-2-oxazolin-5-one (oxazolone) repeated application in mice.
Yukihito Tsukumo, Daisuke Harada, Haruhiko Manabe   +2 more
doaj   +1 more source

Inhibition Mechanism of Gosha-jinki-gan on the Micturition Reflex in Rats

Journal of Pharmacological Sciences, 2004
We investigated the actions of Gosha-jinki-gan, a traditional Japanese medicine containing processed Aconiti tubers, on urinary bladder function in anesthetized rats.
Akinobu Gotoh, Kazuhiro Goto, Atsushi Sengoku, Toshiro Shirakawa, Yoshinobu Akao, Masato Fujisawa, Hiroshi Okada, Soichi Arakawa, Sadao Kamidono   +8 more
doaj   +1 more source