Inflammation induced by snake venoms optimizes envenomation [PDF]
The Journal of Physiology, Volume 604, Issue 14, Page 5831-5852, 15 July 2026.Abstract figure legend Schematic illustrating mechanisms underlying direct vascular absorption and subsequent movement of venom toxins into the tissues consequent to snakebite. A, snakebite into prey deposits venom toxins into the tissue interstitium, with the venom then causing acute inflammation primarily in venules.
Dirk F. van Helden +9 more
wiley +2 more sources
Neurotransmitter Mechanisms of Ketamine and Ketamine–Magnesium Sulfate-Induced Hypothermia: Evidence for Serotonergic and Adrenergic Involvement Without GABAA Contributions [PDF]
Brain SciencesBackground: Ketamine and magnesium sulfate are commonly used perioperatively to prevent shivering, a frequent and clinically relevant complication of spinal and general anesthesia.
Katarina Savić Vujović +6 more
doaj +2 more sources
Evaluating cytidine, uridine, and gabapentin combinations for pain modulation and p-CREB expression in neuropathic model [PDF]
Future Science OAAims To evaluate the analgesic and neuroprotective effects of cytidine, uridine, and gabapentin—administered alone and in combination—in models of diabetic neuropathy and formalin-induced acute and inflammatory pain.Materials & Methods Oral doses of ...
Esam Y. Qnais +6 more
doaj +2 more sources
The clinical effect of an implanted vagus nerve stimulator in a patient with chronic cluster headache and focal epilepsy – A case report [PDF]
Headache: The Journal of Head and Face Pain, Volume 65, Issue 7, Page 1202-1206, July/August 2025.Abstract Background Treatment for chronic cluster headache (CCH) is often insufficient. Non‐invasive vagus nerve stimulation (nVNS) was shown to be effective as acute treatment in episodic cluster headache (ECH) and open‐label studies have shown a potential effect in CCH.
Paulien J. van Tilborg +3 more
wiley +2 more sources
Model of Chronic Itch in Aged Mice: Beneficial Effects of Drugs Affecting Descending Modulatory Systems [PDF]
Acta Dermato-VenereologicaPruritus in the elderly, particularly those cases without skin dryness or other identifiable causes, makes treatment challenging due to the lack of evidence regarding the therapeutic effects of antipruritics. This study proposes an age-related alloknesis
Go Kojima +6 more
doaj +2 more sources
Pairing ampakine with brief hypoxia evokes phrenic neuroplasticity via a spinal NMDA receptor-mediated mechanism [PDF]
FunctionBrief hypoxic episodes drive neuroplasticity in animal models and humans. Pretreatment with an allosteric α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor (R) modulator (“ampakine”) enables a single hypoxic exposure to induce ...
Prajwal P. Thakre +4 more
doaj +2 more sources
Arquivos de Neuro-Psiquiatria, 1967 A metisergide (butanolamida do ácido 1-metil-lisérgico) foi empregada experimentalmente em 78 pacientes com epilepsia psicomotora e com alterações focais (ondas "sharp") de projeção em um dos lobos temporais, no EEG.
Jorge Armbrust-Figueiredo
doaj +1 more source
Mesenchymal stem cell-derived conditioned medium and Methysergide give rise to crosstalk inhibition of 5-HT2A and 5-HT7 receptors in neuroblastoma cells. [PDF]
, 2023 Objective: (s): We aimed to investigate the effects of mesenchymal stem cell secretome and methysergide com-bination on 5-hydroxytryptamine 2A, (5-HT2AR), 5-hydroxytryptamine 7 (5-HT7R), adenosine 2A (A2AR) re-ceptors and CD73 on neuroblastoma cell line ...
Satir-Basaran, GÜZİDE +11 more
core +1 more source
The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors
British Journal of Pharmacology, Volume 180, Issue S2, Page S23-S144, October 2023., 2023 The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands.
Stephen P. H. Alexander +165 more
wiley +1 more source
5‐HT7 receptors mediate dilation of rat cremaster muscle arterioles in vivo
Microcirculation, Volume 30, Issue 5-6, August 2023., 2023 Abstract Objective Serotonin (5‐HT) infusion in vivo causes hypotension and a fall in total peripheral resistance. However, the vascular segment and the receptors that mediate this response remain in question. We hypothesized that 5‐HT7 receptors mediate arteriolar dilation to 5‐HT in skeletal muscle microcirculation.
William F. Jackson +4 more
wiley +1 more source