Results 51 to 60 of about 4,160 (205)

Local haemorrhage induced by Bothrops jararaca venom: relationship to neurogenic inflammation

Mediators of Inflammation, 2000
We investigated morphological alterations induced by s.c. injection of 2.5 μg of Bothrops jararaca venom in rats. Intense disorganisation of collagen fibres was observed 1 min after the venom injection, particularly at regions near vessels and nerves ...
Luis Roberto C. Gonçalves, Mario Mariano   +1 more
doaj   +1 more source

Serotonin receptors on astrocytes in primary cultures: Effects of methysergide and fluoxetine

, 1979
A specific binding of serotonin (at least 50 fmol/mg protein) was demonstrated in mouse astrocytes in primary cultures. This binding was inhibited by methysergide and by fluoxetine.
L. Hertz, F. Baldwin, A. Schousboe
core   +1 more source

Factors associated with efficacy of occipital nerve stimulation in medically intractable chronic cluster headache

Headache: The Journal of Head and Face Pain, Volume 65, Issue 9, Page 1626-1633, October 2025.
Abstract Background/Objective Occipital nerve stimulation (ONS) has become an established therapy for medically intractable chronic cluster headache (MICCH), but unfortunately, one third of the patients do not respond satisfactorily. Reliable predictors of treatment success would help physicians improve indication for ONS in MICCH.
Roemer B. Brandt, Casper S. Lansbergen, Linda Kollenburg, Michel D. Ferrari, Frank J. P. M. Huygen, Cecile C. de Vos, Rolf Fronczek, for the Occipital Nerve Stimulation in Medically Intractable Chronic Cluster Headache (ICON) trial study group, M. D. Ferrari, L. A. Wilbrink, I. F. de Coo, P.G.G. Doesborg, E.C. Bartels, E.W. van Zwet, F.J.P.M. Huygen, W. Mulleners, E. Kurt, R.T.M. van Dongen, O.P. Teernstra, P.J.J. Koehler, G.H. Spincemaille, L.A. Wilbrink, F. Wille, K. Burger, J. Haan, E.G.M. Couturier, J.W. Kallewaard, Peter H. Veltink, R. Buschman   +28 more
wiley   +1 more source

Possible Involvement of Endogenous 5-HT in Aggravation of Cerulein-Induced Acute Pancreatitis in Mice

Journal of Pharmacological Sciences, 2007
The aim of the present study was to elucidate the pathogenic role of endogenous 5-HT in pancreatitis. Injections of cerulein at hourly intervals caused edematous pancreatitis in mice characterized by hyperenzymemia and histological alterations. While the
Kentaro Hamada, Masanori Yoshida, Hiroyuki Isayama, Yoshiki Yagi, Shuichi Kanazashi, Yasunari Kashihara, Koji Takeuchi, Isamu Yamaguchi   +7 more
doaj   +1 more source

Increased neuropeptide Y concentrations in specific hypothalamic nuclei of the rat following treatment with methysergide: evidence that NPY may mediate serotonin's effects on food intake

, 1993
Neuropeptide Y (NPY) is a potent central appetite stimulant found in hypothalamic neurons that have close anatomical associations with neurons containing serotonin, a powerful anorectic agent.
Malabu, Usman H., Dryden, Simon, McCarthy, H. David, Ware, Mark, Williams, Gareth   +4 more
core   +1 more source

Fexofenadine Overcomes Osimertinib Resistance by Inhibiting c‐Met in Non‐Small Cell Lung Cancer

MedComm – Oncology, Volume 4, Issue 2, June 2025.
Fexofenadine was identified as a new Met inhibitory drug by a computational drug repurposing tool called “DRAR‐CPI” via chemical‐protein interactome analysis of known Met inhibitors. It was shown to overcome osimertinib resistance in non‐small cell lung cancer by inhibiting Met in vitro and in vivo.
Kenneth K. W. To, Kwong‐Sak Leung, William C. Cho   +2 more
wiley   +1 more source

15. Cluster Headache

Pain Practice, Volume 25, Issue 5, June 2025.
ABSTRACT Introduction Cluster headache is a rare primary headache disorder characterized by excruciating unilateral pain around the eye, lasting between 15 and 180 min, accompanied by ipsilateral cranial autonomic symptoms. Cluster headache is classified into two forms: episodic and chronic, with chronic cluster headache defined by pain‐free intervals ...
Casper S. Lansbergen, Rolf Fronczek, Leopoldine A. Wilbrink, Steven P. Cohen, Cecile C. de Vos, Frank J. P. M. Huygen   +5 more
wiley   +1 more source

Pharmacological characterization of a 5-HT1-type serotonin receptor in the red flour beetle, Tribolium castaneum.

PLoS ONE, 2013
Serotonin (5-hydroxytryptamine, 5-HT) is known for its key role in modulating diverse physiological processes and behaviors by binding various 5-HT receptors.
Rut Vleugels, Cynthia Lenaerts, Arnd Baumann, Jozef Vanden Broeck, Heleen Verlinden   +4 more
doaj   +1 more source

Changes in use of acute and preventive medications for migraine after erenumab initiation over 12 months: A United States retrospective cohort study

Headache: The Journal of Head and Face Pain, Volume 65, Issue 1, Page 68-79, January 2025.
Abstract Objective To assess changes in real‐world use of acute and preventive medications for migraine over a 12‐month follow‐up period in the United States following initiation of the anti‐calcitonin gene‐related peptide (CGRP) pathway monoclonal antibody (mAb) erenumab.
Jasjit K. Multani, Robert Urman, Andrew S. Park, Karminder Gill, Fiston Vuvu, Kainan Sun, Leah B. Patel, Karen M. Stockl, Kevin Hawkins, Christopher Rhyne, Mark E. Bensink   +10 more
wiley   +1 more source

Influência da naloxona e metisergida sobre o efeito analgésico do laser em baixa intensidade em modelo experimental de dor Influencia de la naloxona y la metisergida sobre el efecto analgésico del láser en baja intensidad en modelo experimental de dolor Influence of naloxone and methysergide on the analgesic effects of low-level laser in an experimental pain model

Revista Brasileira de Anestesiologia, 2010
JUSTIFICATIVA E OBJETIVOS: A fototerapia com laser (LPT) é um método analgésico promissor, embora seu mecanismo de ação não seja totalmente conhecido. O objetivo deste estudo foi avaliar se a ação da LPT é dependente da ativação de receptores opioides ou
André Peres e Serra, Hazem A Ashmawi
doaj   +1 more source