Results 51 to 60 of about 5,127 (197)

Clinical Practice Guideline for Headache Disorders 2021

Neurology and Clinical Neuroscience, Volume 13, Issue 6, Page 389-407, November 2025.
ABSTRACT The International Headache Society published the International Classification of Headache Disorders, 3rd edition in 2018. In this classification, Chapter 3—previously “Cluster headache and other trigeminal‐autonomic cephalalgias”—was renamed “Trigeminal‐autonomic cephalalgias (TACs).” Trigeminal‐autonomic cephalalgias are a group of disorders ...
Nobuo Araki, Takao Takeshima, Hisaka Igarashi, Toshihiko Shimizu, Mamoru Shibata, Muneto Tatsumoto, Noboru Imai, Shoji Kikui, Tatsuo Iwashita, Daisuke Danno, on behalf of the Study Group for Headache Clinical Practice Guideline Development   +10 more
wiley   +1 more source

Factors associated with efficacy of occipital nerve stimulation in medically intractable chronic cluster headache

Headache: The Journal of Head and Face Pain, Volume 65, Issue 9, Page 1626-1633, October 2025.
Abstract Background/Objective Occipital nerve stimulation (ONS) has become an established therapy for medically intractable chronic cluster headache (MICCH), but unfortunately, one third of the patients do not respond satisfactorily. Reliable predictors of treatment success would help physicians improve indication for ONS in MICCH.
Roemer B. Brandt, Casper S. Lansbergen, Linda Kollenburg, Michel D. Ferrari, Frank J. P. M. Huygen, Cecile C. de Vos, Rolf Fronczek, for the Occipital Nerve Stimulation in Medically Intractable Chronic Cluster Headache (ICON) trial study group, M. D. Ferrari, L. A. Wilbrink, I. F. de Coo, P.G.G. Doesborg, E.C. Bartels, E.W. van Zwet, F.J.P.M. Huygen, W. Mulleners, E. Kurt, R.T.M. van Dongen, O.P. Teernstra, P.J.J. Koehler, G.H. Spincemaille, L.A. Wilbrink, F. Wille, K. Burger, J. Haan, E.G.M. Couturier, J.W. Kallewaard, Peter H. Veltink, R. Buschman   +28 more
wiley   +1 more source

Local haemorrhage induced by Bothrops jararaca venom: relationship to neurogenic inflammation

Mediators of Inflammation, 2000
We investigated morphological alterations induced by s.c. injection of 2.5 μg of Bothrops jararaca venom in rats. Intense disorganisation of collagen fibres was observed 1 min after the venom injection, particularly at regions near vessels and nerves ...
Luis Roberto C. Gonçalves, Mario Mariano   +1 more
doaj   +1 more source

Fexofenadine Overcomes Osimertinib Resistance by Inhibiting c‐Met in Non‐Small Cell Lung Cancer

MedComm – Oncology, Volume 4, Issue 2, June 2025.
Fexofenadine was identified as a new Met inhibitory drug by a computational drug repurposing tool called “DRAR‐CPI” via chemical‐protein interactome analysis of known Met inhibitors. It was shown to overcome osimertinib resistance in non‐small cell lung cancer by inhibiting Met in vitro and in vivo.
Kenneth K. W. To, Kwong‐Sak Leung, William C. Cho   +2 more
wiley   +1 more source

Possible Involvement of Endogenous 5-HT in Aggravation of Cerulein-Induced Acute Pancreatitis in Mice

Journal of Pharmacological Sciences, 2007
The aim of the present study was to elucidate the pathogenic role of endogenous 5-HT in pancreatitis. Injections of cerulein at hourly intervals caused edematous pancreatitis in mice characterized by hyperenzymemia and histological alterations. While the
Kentaro Hamada, Masanori Yoshida, Hiroyuki Isayama, Yoshiki Yagi, Shuichi Kanazashi, Yasunari Kashihara, Koji Takeuchi, Isamu Yamaguchi   +7 more
doaj   +1 more source

Striatal dopamine D-2 receptors attenuate neuropathic hypersensitivity in the rat [PDF]

, 2007
Earlier studies indicate that striatal dopamine D-2 receptors are involved in pain regulation in non-neuropathic conditions. We assessed whether striatal dopamine D-2 receptors contribute to pain regulation also in neuropathic conditions.
Ansah, Osei B., Leite-Almeida, Hugo, Pertovaara, Antti, Wei, Hong   +3 more
core   +1 more source

15. Cluster Headache

Pain Practice, Volume 25, Issue 5, June 2025.
ABSTRACT Introduction Cluster headache is a rare primary headache disorder characterized by excruciating unilateral pain around the eye, lasting between 15 and 180 min, accompanied by ipsilateral cranial autonomic symptoms. Cluster headache is classified into two forms: episodic and chronic, with chronic cluster headache defined by pain‐free intervals ...
Casper S. Lansbergen, Rolf Fronczek, Leopoldine A. Wilbrink, Steven P. Cohen, Cecile C. de Vos, Frank J. P. M. Huygen   +5 more
wiley   +1 more source

Inaugural Review Prize 2023: The exercise hyperpnoea dilemma: A 21st‐century perspective

Experimental Physiology, Volume 109, Issue 8, Page 1217-1237, 1 August 2024.
Abstract During mild or moderate exercise, alveolar ventilation increases in direct proportion to metabolic rate, regulating arterial CO2 pressure near resting levels. Mechanisms giving rise to the hyperpnoea of exercise are unsettled despite over a century of investigation.
Joseph F. Welch, Gordon S. Mitchell
wiley   +1 more source

Pharmacological characterization of a 5-HT1-type serotonin receptor in the red flour beetle, Tribolium castaneum.

PLoS ONE, 2013
Serotonin (5-hydroxytryptamine, 5-HT) is known for its key role in modulating diverse physiological processes and behaviors by binding various 5-HT receptors.
Rut Vleugels, Cynthia Lenaerts, Arnd Baumann, Jozef Vanden Broeck, Heleen Verlinden   +4 more
doaj   +1 more source

Excitatory action of low frequency depolarizing GABA/glycine synaptic inputs is prevalent in prenatal spinal SOD1G93A motoneurons

The Journal of Physiology, Volume 602, Issue 5, Page 913-932, 1 March 2024.
Abstract figure legend Left: the firing of wild‐type (WT) prenatal (embyronic day 17.5) lumbar spinal motoneurons (MNs) exhibiting a low input resistance (<100 MΩ) is inhibited by low frequency depolarizing GABAergic/glycinergic postsynaptic potentials (dGPSPs). Red dots indicate GABA/glycine terminals on the MN soma and proximal dendrites.
Hongmei Zhu, Urvashi Dalvi, William Cazenave, Daniel Cattaert, Pascal Branchereau   +4 more
wiley   +1 more source