Results 1 to 10 of about 1,410,069 (283)

Pharmacists in clozapine clinics improving physical health monitoring [PDF]

open access: yesMental Health Clinician, 2022
Introduction: People living with schizophrenia have a higher rate of comorbid physical health diseases and compared with the general population die earlier due to these diseases.
Greg Spann, BPharm, GCert Psychiatric Therapeutics   +2 more
doaj   +1 more source

Neurointervention in the Era of COVID-19: Korean Nationwide Survey, Literature Review, and Recommendations [PDF]

open access: yesNeurointervention, 2021
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has had a tremendous impact on healthcare systems worldwide. Although the most common presentation of COVID-19 is respiratory illness,
Woong Jae Lee, Jun Soo Byun
doaj   +1 more source

Dual inhibition of αvβ6 and αvβ1 reduces fibrogenesis in lung tissue explants from patients with IPF

open access: yesRespiratory Research, 2021
Rationale αv integrins, key regulators of transforming growth factor-β activation and fibrogenesis in in vivo models of pulmonary fibrosis, are expressed on abnormal epithelial cells (αvβ6) and fibroblasts (αvβ1) in fibrotic lungs.
Martin L. Decaris   +27 more
doaj   +1 more source

The CNS-penetrant soluble guanylate cyclase stimulator CYR119 attenuates markers of inflammation in the central nervous system

open access: yesJournal of Neuroinflammation, 2021
Background Inflammation in the central nervous system (CNS) is observed in many neurological disorders. Nitric oxide-soluble guanylate cyclase-cyclic guanosine monophosphate (NO–sGC–cGMP) signaling plays an essential role in modulating neuroinflammation.
Susana S. Correia   +16 more
doaj   +1 more source

Clinical Pharmacology & Therapeutics: Past, Present, and Future. [PDF]

open access: yes, 2017
Clinical Pharmacology & Therapeutics (CPT), the definitive and timely source for advances in human therapeutics, transcends the drug discovery, development, regulation, and utilization continuum to catalyze, evolve, and disseminate discipline ...
Terzic, Andre, Waldman, Scott A.
core   +2 more sources

Pregabalin: a range of misuse-related unanswered questions [PDF]

open access: yes, 2019
© 2019 The Authors.
Chiappini, Stephania, Schifano, Fabrizio
core   +2 more sources

Antibody-based binding domain fused to TCRγ chain facilitates T cell cytotoxicity for potent anti-tumor response

open access: yesOncogenesis, 2023
Chimeric antigen receptor T-cell (CAR-T) therapy has demonstrated potent clinical efficacy in the treatment of hematopoietic malignancies. However, the application of CAR-T in solid tumors has been limited due in part to the expression of inhibitory ...
Zhao Chen   +25 more
doaj   +1 more source

Parameters in predicting the risk of a prolonged hospital stay in patients with acute exacerbation of chronic obstructive pulmonary disease: a single-centre experience [PDF]

open access: yesMedicinski Glasnik, 2023
Aim To identify clinical and laboratory parameters on admission and/or during a hospital stay that would predict prolonged hospital stay in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods A retrospective cross-
Aida Mujaković   +8 more
doaj   +1 more source

Anomeric O-Functionalization of Carbohydrates for Chemical Conjugation to Vaccine Constructs. [PDF]

open access: yes, 2018
Carbohydrates mediate a wide range of biological interactions, and understanding these processes benefits the development of new therapeutics. Isolating sufficient quantities of glycoconjugates from biological samples remains a significant challenge ...
Gervay-Hague, Jacquelyn   +2 more
core   +1 more source

Tau Aggregation Inhibitor Therapy : An Exploratory Phase 2 Study in Mild or Moderate Alzheimer's Disease [PDF]

open access: yes, 2015
ACKNOWLEDGMENTS We thank patients and their caregivers for their participation in the study and are indebted to all the investigators involved in the study, particularly Drs. Douglas Fowlie and Donald Mowat for their helpful contributions to the clinical
Bentham, Peter   +7 more
core   +1 more source

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