Results 21 to 30 of about 1,064,547 (319)

Therapeutics Letter 124 [PDF]

open access: yes, 2019
Therapeutics Letter 124 provides results of the Therapeutics Initiative's fifth readership survey to evaluate perceptions of our academic unit and the impact of Therapeutics Initiative learning events.Medicine, Faculty ofAnesthesiology, Pharmacology and ...
Therapeutics Initiative (University of British Columbia)
core  

Therapeutics Letter 127 [PDF]

open access: yes, 2020
Therapeutics Letter 127 discusses personal prescribing portraits as an innovative method for community-based physicians to monitor and evaluate the appropriateness of their prescribing practices.Medicine, Faculty ofAnesthesiology, Pharmacology and ...
Therapeutics Initiative (University of British Columbia)
core  

Health‐Related Social Needs in Children With Sickle Cell Disease Are Associated With Worse Health‐Related Quality of Life

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with sickle cell disease (SCD) face multiple acute and chronic medical complications that may impact their quality of life as reported by patients themselves. Health‐related social needs (HRSNs), such as food and housing insecurity, are common in people with SCD, but the association between HRSNs and patient‐reported ...
Sarah J. Marks   +5 more
wiley   +1 more source

Therapeutics Letter 122 [PDF]

open access: yes, 2019
Therapeutics Letter 122 is the second of two issues celebrating 25 years of The Therapeutics Initiative by highlighting key conclusions from the 120 issues of the Therapeutics Letter that have been published to date.Medicine, Faculty ofAnesthesiology ...
Therapeutics Initiative (University of British Columbia)
core  

Therapeutics Letter 136 [PDF]

open access: yes, 2022
Therapeutics Letter 136 examines conflicts of interest in primary care and the pharmaceutical industry. Conclusions: Industry sponsorship of clinical trials can lead to biased conclusions, including exaggerated claims of efficacy and underestimation of ...
Therapeutics Initiative (University of British Columbia)
core  

Spider-Venom Peptides: Structure, Bioactivity, Strategy, and Research Applications

open access: yesMolecules, 2023
Spiders (Araneae), having thrived for over 300 million years, exhibit remarkable diversity, with 47,000 described species and an estimated 150,000 species in existence. Evolving with intricate venom, spiders are nature’s skilled predators.
Ruiyin Guo   +5 more
doaj   +1 more source

Cup‐Like Nuclei Is a Hallmark of DUX4/ERG Acute Lymphoblastic Leukemia and Reveals Cytoplasmic Mitochondria Accumulation

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Cup‐like nuclei are a distinctive morphological feature observed in certain cases of acute lymphoblastic leukemia (ALL). We provide evidence that they characterize DUX4/ERG ALL independently of IKZF1 deletion and reveal marked mitochondrial accumulation in this ALL subset.
Chloé Arfeuille   +9 more
wiley   +1 more source

Therapeutics Letter 9 [PDF]

open access: yes, 1995
Therapeutics Letter 9 reviews the recommendations published by The Therapeutics Initiative in our first year, including some updated information based on feedback which we have received from readers of the Therapeutics Letter.Medicine, Faculty ...
Therapeutics Initiative (University of British Columbia)
core  

AAV9:PKP2 improves heart function and survival in a Pkp2-deficient mouse model of arrhythmogenic right ventricular cardiomyopathy

open access: yesCommunications Medicine
Background Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a familial cardiac disease associated with ventricular arrhythmias and an increased risk of sudden cardiac death. Currently, there are no approved treatments that address the underlying
Iris Wu   +31 more
doaj   +1 more source

Posttranslational and Therapeutic Control of Gasdermin-Mediated Pyroptosis and Inflammation

open access: yesFrontiers in Immunology, 2021
Pyroptosis is a proinflammatory form of cell death, mediated by membrane pore-forming proteins called gasdermins. Gasdermin pores allow the release of the pro-inflammatory cytokines IL-1β and IL-18 and cause cell swelling and cell lysis leading to ...
Fabian A. Fischer   +2 more
doaj   +1 more source

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