Results 21 to 30 of about 1,140,114 (148)
Predictions of tDCS treatment response in PTSD patients using EEG based classification
Frontiers in Psychiatry, 2022 Transcranial direct current stimulation (tDCS) is an emerging therapeutic tool for treating posttraumatic stress disorder (PTSD). Prior studies have shown that tDCS responses are highly individualized, thus necessitating the individualized optimization ...
Sangha Kim +5 more
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, 2019 Therapeutics Letter 122 is the second of two issues celebrating 25 years of The Therapeutics Initiative by highlighting key conclusions from the 120 issues of the Therapeutics Letter that have been published to date.Medicine, Faculty ofAnesthesiology ...
Therapeutics Initiative (University of British Columbia)
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WRN inhibition leads to its chromatin-associated degradation via the PIAS4-RNF4-p97/VCP axis
Nature CommunicationsSynthetic lethality provides an attractive strategy for developing targeted cancer therapies. For example, cancer cells with high levels of microsatellite instability (MSI-H) are dependent on the Werner (WRN) helicase for survival.
Fernando Rodríguez Pérez +25 more
doaj +1 more source
Nucleic Acid Therapeutics for Neurological Diseases
, 2020 Oligonucleotide therapeutics are emerging as a promising class of therapeutics in various areas of human health. In the long run, oligonucleotides are likely to become a major class of therapeutics, on par with small molecules and biologics.
Watts, Jonathan K +2 more
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, 1995 Therapeutics Letter 9 reviews the recommendations published by The Therapeutics Initiative in our first year, including some updated information based on feedback which we have received from readers of the Therapeutics Letter.Medicine, Faculty ...
Therapeutics Initiative (University of British Columbia)
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Communications BiologyXRN1 (5’-3’ exoribonuclease 1) degrades RNA from the 5′ → 3′ direction and utilizes both single- and double-stranded RNA as substrates. XRN1 plays a critical role in mRNA turnover as well as regulating the cellular response to viral infection.
Gordon J. Lockbaum +21 more
doaj +1 more source
, 2019 Therapeutics Letter 121 is the first of two issues celebrating 25 years of The Therapeutics Initiative by highlighting key conclusions from the 120 issues of the Therapeutics Letter that have been published to date.Medicine, Faculty ofAnesthesiology ...
Therapeutics Initiative (University of British Columbia)
core +1 more source
Scientific ReportsMultiple sclerosis (MS) is a chronic neurological disease characterized by inflammatory demyelination that disrupts neuronal transmission resulting in neurodegeneration progressive disability.
Michael M. Poon +13 more
doaj +1 more source
, 2007 Therapeutics Letter 64 provides results of the Therapeutics Initiative's (TI) third readership survey to evaluate perceptions of TI educational activities.Medicine, Faculty ofAnesthesiology, Pharmacology and Therapeutics, Department ofReviewedThe UBC TI ...
Therapeutics Initiative (University of British Columbia)
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Targeted degradation of GSPT1 and NEK7 by a molecular glue prodrug for treatment of HCC
Communications ChemistryTargeted Protein Degradation (TPD) technology, in the form of CRBN-modulating molecular glues, offers numerous unprecedented therapeutic benefits as evidenced by the success of approved high-value immunomodulatory imide drugs (IMiDs) such as lenalidomide
Przemysław Glaza +28 more
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