Results 21 to 30 of about 43,427 (313)

A characterization of the Manduca sexta serotonin receptors in the context of olfactory neuromodulation.

PLoS ONE, 2013
Neuromodulation, the alteration of individual neuron response properties, has dramatic consequences for neural network function and is a phenomenon observed across all brain regions and taxa.
Andrew M Dacks, Vincenzina Reale, Yeli Pi, Wujie Zhang, Joel B Dacks, Alan J Nighorn, Peter D Evans   +6 more
doaj   +1 more source

Modern approaches to drug treatment for vestibular vertigo

Неврология, нейропсихиатрия, психосоматика, 2021
In recent years, some progress has been achieved in elaborating the algorithms and standards for the treatment of many conditions accompanied by vertigo. The current possibilities of treating vestibular vertigo consist of a gradually expanding arsenal of
M. V. Zamergrad, S. V. Morozova
doaj   +1 more source

Serotonin-Induced Hypersensitivity via Inhibition of Catechol O-Methyltransferase Activity

Molecular Pain, 2012
The subcutaneous and systemic injection of serotonin reduces cutaneous and visceral pain thresholds and increases responses to noxious stimuli. Different subtypes of 5-hydroxytryptamine (5-HT) receptors are suggested to be associated with different types
Tsao Douglas, Wieskopf Jeffrey S, Rashid Naim, Sorge Robert E, Redler Rachel L, Segall Samantha K, Mogil Jeffrey S, Maixner William, Dokholyan Nikolay V, Diatchenko Luda   +9 more
doaj   +1 more source

Acute 5-HT2C Receptor Antagonist SB-242084 Treatment Affects EEG Gamma Band Activity Similarly to Chronic Escitalopram

Frontiers in Pharmacology, 2020
Serotonin 2C receptors (5-HT2CRs) are implicated in the pathomechanism and treatment of anxiety and depression. Recently, as a new biomarker of depression, alterations in the gamma power of the electroencephalogram (EEG) have been suggested.
Noémi Papp, Szabolcs Koncz, Diána Kostyalik, Tamás Kitka, Péter Petschner, Péter Petschner, Szilvia Vas, Szilvia Vas, Szilvia Vas, György Bagdy, György Bagdy, György Bagdy   +11 more
doaj   +1 more source

Serotonin 5-HT2A receptor activation blocks TNF-α mediated inflammation in vivo. [PDF]

PLoS ONE, 2013
Tumor necrosis factor alpha (TNF-α) plays a key role in inflammation, and its production and signaling contribute to many inflammatory related diseases.
Felix Nau, Bangning Yu, David Martin, Charles D Nichols   +3 more
doaj   +1 more source

Ergotamine enhances circadian amplitude and diurnally mitigates nitroglycerin-induced mechanical hypersensitivity

The Journal of Headache and Pain
Background Cluster headache and migraine have a circadian timing of attacks and are linked to the trigeminovascular system. Recently the trigeminal ganglion was found to have a strong circadian rhythm, with the serotonin 2A receptor identified as a clock-
Chorong Han, Hwayoung Baek, Ji Ye Lim, Eunju Kim, Celia K. Tran, Emma Freeman, Zheng Chen, Seung-Hee Yoo, Mark J. Burish   +8 more
doaj   +1 more source

Pharmacological modulation of aversive responsiveness in honey bees

Frontiers in Behavioral Neuroscience, 2014
Within a honey bee colony, individuals performing different tasks exhibit different sensitivities to noxious stimuli. Noxious-stimulus sensitivity can be quantified in harnessed bees by measuring the sting extension response (SER) to a series of ...
Stevanus Rio Tedjakumala, Margaux eAimable, Martin eGiurfa   +2 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

A computational pipeline for a neurotransmitter-centric analysis of the effects of psychiatric medication on EEG spectral power

Frontiers in Psychiatry
IntroductionTraditional pharmaco-electroencephalography (EEG) studies have mainly examined the effects of psychotropic medications at the level of individual drugs or broad drug classes, limiting biological specificity and clinical translation.
Samar Samy Zekerallah, Anna Alexandra Maxion, Anna Alexandra Maxion, Jana Zweerings, Paula Teucher, Paula Teucher, Klaus Mathiak, Ekaterina Kutafina, Arnim Johannes Gaebler, Arnim Johannes Gaebler   +9 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source