Results 21 to 30 of about 44,540 (313)

A current view of serotonin transporters [version 1; referees: 3 approved]

F1000Research, 2016
Serotonin transporters (SERTs) are largely recognized for one aspect of their function—to transport serotonin back into the presynaptic terminal after its release.
Louis J. De Felice
doaj   +1 more source

3D-QSAR modeling and pharmacophore study of serotonin 5HT-₂A receptors antagonists [PDF]

Arhiv za farmaciju, 2017
Creation of a statistically reliable 3D-QSAR (Quantitative Structure Activity Relationships) model enables definition of the structure of the pharmacophore for antagonists of serotonin 5-HT2A receptors and selection of the key molecular determinants for ...
Antonijević Mirjana, Nikolić Katarina, Vučićević Jelica, Oljačić Slavica, Agbaba Danica   +4 more
doaj   +1 more source

Immunohistochemical Evaluation of Role of Serotonin in Pathogenesis of Psoriasis [PDF]

Journal of Clinical and Diagnostic Research, 2016
Introduction: Psoriasis is a common skin disorder characterized by erythaematosquamous papules and plaques. It is known to be associated with stressful and depressive disorders. Serotonin is a neurotransmitter that plays a role in the pathogenesis of
Sheren Fouad Younes, Ola Ahmed Bakry
doaj   +1 more source

The Effects of Serotonin Receptor Antagonists on Contraction and Relaxation Responses Induced by Electrical Stimulation in the Rat Small Intestine

, 2014
Background: The main source of 5-HT in body is in enterchromafin cells of intestine, different studies mentioned different roles for endogenous 5-HT and receptors involved and it is not clearified the mechanism of action of endogenous 5-HT. Objectives:
Farideh A. Javid, Javid, Farideh A., Mashhadi, Farzaneh Farajian, Robert J. Naylor, Farzaneh Farajian Mashhadi, Naylor, Robert J.   +5 more
core   +1 more source

A characterization of the Manduca sexta serotonin receptors in the context of olfactory neuromodulation.

PLoS ONE, 2013
Neuromodulation, the alteration of individual neuron response properties, has dramatic consequences for neural network function and is a phenomenon observed across all brain regions and taxa.
Andrew M Dacks, Vincenzina Reale, Yeli Pi, Wujie Zhang, Joel B Dacks, Alan J Nighorn, Peter D Evans   +6 more
doaj   +1 more source

Modern approaches to drug treatment for vestibular vertigo

Неврология, нейропсихиатрия, психосоматика, 2021
In recent years, some progress has been achieved in elaborating the algorithms and standards for the treatment of many conditions accompanied by vertigo. The current possibilities of treating vestibular vertigo consist of a gradually expanding arsenal of
M. V. Zamergrad, S. V. Morozova
doaj   +1 more source

Serotonin-Induced Hypersensitivity via Inhibition of Catechol O-Methyltransferase Activity

Molecular Pain, 2012
The subcutaneous and systemic injection of serotonin reduces cutaneous and visceral pain thresholds and increases responses to noxious stimuli. Different subtypes of 5-hydroxytryptamine (5-HT) receptors are suggested to be associated with different types
Tsao Douglas, Wieskopf Jeffrey S, Rashid Naim, Sorge Robert E, Redler Rachel L, Segall Samantha K, Mogil Jeffrey S, Maixner William, Dokholyan Nikolay V, Diatchenko Luda   +9 more
doaj   +1 more source

Acute 5-HT2C Receptor Antagonist SB-242084 Treatment Affects EEG Gamma Band Activity Similarly to Chronic Escitalopram

Frontiers in Pharmacology, 2020
Serotonin 2C receptors (5-HT2CRs) are implicated in the pathomechanism and treatment of anxiety and depression. Recently, as a new biomarker of depression, alterations in the gamma power of the electroencephalogram (EEG) have been suggested.
Noémi Papp, Szabolcs Koncz, Diána Kostyalik, Tamás Kitka, Péter Petschner, Péter Petschner, Szilvia Vas, Szilvia Vas, Szilvia Vas, György Bagdy, György Bagdy, György Bagdy   +11 more
doaj   +1 more source

Serotonin 5-HT2A receptor activation blocks TNF-α mediated inflammation in vivo. [PDF]

PLoS ONE, 2013
Tumor necrosis factor alpha (TNF-α) plays a key role in inflammation, and its production and signaling contribute to many inflammatory related diseases.
Felix Nau, Bangning Yu, David Martin, Charles D Nichols   +3 more
doaj   +1 more source

Ergotamine enhances circadian amplitude and diurnally mitigates nitroglycerin-induced mechanical hypersensitivity

The Journal of Headache and Pain
Background Cluster headache and migraine have a circadian timing of attacks and are linked to the trigeminovascular system. Recently the trigeminal ganglion was found to have a strong circadian rhythm, with the serotonin 2A receptor identified as a clock-
Chorong Han, Hwayoung Baek, Ji Ye Lim, Eunju Kim, Celia K. Tran, Emma Freeman, Zheng Chen, Seung-Hee Yoo, Mark J. Burish   +8 more
doaj   +1 more source