Results 21 to 30 of about 465,747 (346)

Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis

Cell, 2015
SUMMARY The gastrointestinal (GI) tract contains much of the body’s serotonin (5-hydroxytryptamine, 5-HT), but mechanisms controlling the metabolism of gut-derived 5-HT remain unclear.
J. Yano, Kristie B. Yu, Gregory P. Donaldson, Gauri G. Shastri, P. Ann, Liang Ma, C. Nagler, R. Ismagilov, S. Mazmanian, E. Hsiao   +9 more
semanticscholar   +1 more source

Increased release of serotonin from rat primary isolated adult cardiac myofibroblasts

Scientific Reports, 2021
Elevated blood serotonin levels have been observed in patients with heart failure and serotonin has a role in pathological cardiac function. The serotonin receptor system was examined in adult rat isolated cardiac fibroblast and myofibroblast cells. This
Emiri Tarbit, Indu Singh, Jason Nigel Peart, Svetlana Bivol, Roselyn Barbara Rose’Meyer   +4 more
doaj   +1 more source

Sustained Exposure to 3,4-Methylenedioxymethamphetamine Induces the Augmentation of Exocytotic Serotonin Release in Rat Organotypic Raphe Slice Cultures

Journal of Pharmacological Sciences, 2010
3,4-Methylenedioxymethamphetamine (MDMA) causes serotonin efflux via serotonin transporter. Recently, we have reported that sustained exposure to MDMA induced an augmentation of serotonin release in rat raphe serotonergic slice cultures.
Kazuki Nagayasu, Maiko Kitaichi, Hisashi Shirakawa, Takayuki Nakagawa, Shuji Kaneko   +4 more
doaj   +1 more source

Serotonin induced hepatic steatosis is associated with modulation of autophagy and notch signaling pathway

Cell Communication and Signaling, 2018
Background Besides its neurotransmitter and vasoconstriction functions, serotonin is an important mediator of numerous biological processes in peripheral tissues including cell proliferation, steatosis, and fibrogenesis.
Suryakant Niture, Maxwell A. Gyamfi, Habib Kedir, Elena Arthur, Habtom Ressom, Gagan Deep, Deepak Kumar   +6 more
doaj   +1 more source

Telotristat ethyl reverses myxomatous changes in mice mitral valves

Frontiers in Cardiovascular Medicine, 2022
RationaleMyxomatous mitral valve degeneration is a common pathological manifestation of mitral valve regurgitation, with or without valvular prolapse.
Xinmei Wang, Danielle Kuban-Johnston, Pablo Lapuerta, Carla M. R. Lacerda   +3 more
doaj   +1 more source

Serotonin syndrome triggered by postoperative administration of serotonin noradrenaline reuptake inhibitor (SNRI)

JA Clinical Reports, 2019
Background Serotonin syndrome is a rare but potentially severe disease, which is caused by hyperstimulation of serotonin receptors in the central nervous system.
Junko Takata, Tomoko Arashi, Ayako Abe, Shoko Arai, Naoko Haruyama   +4 more
doaj   +1 more source

Localization of the Serotonin Transporter in the Dog Intestine and Comparison to the Rat and Human Intestines

Frontiers in Veterinary Science, 2022
Serotonin is crucial in gastrointestinal functions, including motility, sensitivity, secretion, and the inflammatory response. The serotonin transporter (SERT), responsible for serotonin reuptake and signaling termination, plays a prominent role in ...
Roberto Chiocchetti, Giorgia Galiazzo, Fiorella Giancola, Claudio Tagliavia, Chiara Bernardini, Monica Forni, Marco Pietra   +6 more
doaj   +1 more source

Serotonin in Animal Cognition and Behavior

International Journal of Molecular Sciences, 2020
Serotonin (5-hydroxytryptamine, 5-HT) is acknowledged as a major neuromodulator of nervous systems in both invertebrates and vertebrates. It has been proposed for several decades that it impacts animal cognition and behavior.
Julien Bacqué-Cazenave, Rahul Bharatiya, G. Barrière, J. Delbecque, Nouhaila Bouguiyoud, G. Di Giovanni, D. Cattaert, P. De Deurwaerdère   +7 more
semanticscholar   +1 more source

Serotonin and epilepsy [PDF]

Journal of Neurochemistry, 2006
AbstractIn recent years, there has been increasing evidence that serotonergic neurotransmission modulates a wide variety of experimentally induced seizures. Generally, agents that elevate extracellular serotonin (5‐HT) levels, such as 5‐hydroxytryptophan and serotonin reuptake blockers, inhibit both focal and generalized seizures, although exceptions ...
Gyorgy, Bagdy, Valeria, Kecskemeti, Pal, Riba, Rita, Jakus   +3 more
openaire   +2 more sources

Serotonin Pathway in Cancer

International Journal of Molecular Sciences, 2021
Serotonin (5-hydroxytryptamine, 5-HT) is a biogenic monoamine produced from the essential amino acid tryptophan. Serotonin’s role as a neurotransmitter in the central nervous system and a motility mediator in the gastrointestinal tract has been well ...
Pragathi Balakrishna, Sagila George, H. Hatoum, S. Mukherjee   +3 more
semanticscholar   +1 more source