Results 21 to 30 of about 76,875 (253)
PLoS ONE, 2011 BackgroundWeibel-Palade bodies (WPB) are endothelial cell (EC) specific secretory organelles containing Von Willebrand factor (VWF). The temperature-dependence of Ca(2+)-driven WPB exocytosis is not known, although indirect evidence suggests that WPB ...
Lindsay Hewlett +6 more
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PLoS ONE, 2020 α-Klotho is a type 1 transmembrane protein that exhibits aging suppression function. The large amino-terminal extracellular domain of α-klotho is shed as soluble klotho (sKlotho) and functions as a circulating cardioprotective hormone.
Jian Xie +4 more
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Anaphylactic Degranulation of Mast Cells: Focus on Compound Exocytosis
Journal of Immunology Research, 2019 Anaphylaxis is a notorious type 2 immune response which may result in a systemic response and lead to death. A precondition for the unfolding of the anaphylactic shock is the secretion of inflammatory mediators from mast cells in response to an allergen,
Ofir Klein, Ronit Sagi-Eisenberg
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A Novel Role of the TRPM4 Ion Channel in Exocytosis
Cells, 2022 Under physiological conditions, the widely expressed calcium-activated TRPM4 channel conducts sodium into cells. This sodium influx depolarizes the plasma membrane and reduces the driving force for calcium entry.
Paulina Stokłosa +2 more
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The dynamics of somatic exocytosis in monoaminergic neurons
Frontiers in Physiology, 2012 Some monoaminergic neurons can release neurotransmitters by exocytosis from their cell bodies. The amount of monoamine released by somatic exocytosis can be comparable to that released by synaptic exocytosis, though neither the underlying mechanisms nor ...
Bidyut eSarkar +6 more
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Network-based insights into miRNA regulation of β-cell insulin secretion in type 2 diabetes
iScienceSummary: Increasing evidence suggests that microRNAs (miRNAs) contribute to pancreatic β-cell compensation during type 2 diabetes (T2D) pathogenesis. To examine miRNA-mRNA interactions in human islets and their roles in β-cell insulin secretion and T2D ...
Elaine Cowan +7 more
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Cell Reports, 2012 Although calcium influx triggers endocytosis at many synapses and non-neuronal secretory cells, the identity of the calcium channel is unclear. The plasma membrane voltage-dependent calcium channel (VDCC) is a candidate, and it was recently proposed that
Lei Xue +7 more
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PLoS ONE, 2014 Impairment in beta-cell exocytosis is associated with reduced insulin secretion and diabetes. Here we aimed to investigate the dynamics of Ca2+-dependent insulin exocytosis with respect to pool depletion and Ca2+-current inactivation.
Morten Gram Pedersen +4 more
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FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Human pancreatic islet miRNA-mRNA networks of altered miRNAs due to glycemic status
iScience, 2022 Summary: MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression via mRNA targeting, playing important roles in the pancreatic islets. We aimed to identify molecular pathways and genomic regulatory regions associated with altered miRNA
Alexandros Karagiannopoulos +5 more
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