Results 21 to 30 of about 76,537 (156)

GLUT4 exocytosis

Journal of Cell Science, 2011
GLUT4 is an insulin-regulated glucose transporter that is responsible for insulin-regulated glucose uptake into fat and muscle cells. In the absence of insulin, GLUT4 is mainly found in intracellular vesicles referred to as GLUT4 storage vesicles (GSVs).
Jacqueline, Stöckli, Daniel J, Fazakerley, David E, James   +2 more
openaire   +3 more sources

Dual Effect of Rosuvastatin on Glucose Homeostasis Through Improved Insulin Sensitivity and Reduced Insulin Secretion

EBioMedicine, 2016
Statins are beneficial in the treatment of cardiovascular disease (CVD), but these lipid-lowering drugs are associated with increased incidence of new on-set diabetes.
Vishal A. Salunkhe, Inês G. Mollet, Jones K. Ofori, Helena A. Malm, Jonathan L.S. Esguerra, Thomas M. Reinbothe, Karin G. Stenkula, Anna Wendt, Lena Eliasson, Jenny Vikman   +9 more
doaj   +1 more source

Effects of the surface charge of polyamidoamine dendrimers on cellular exocytosis and the exocytosis mechanism in multidrug-resistant breast cancer cells

Journal of Nanobiotechnology, 2021
Background Polyamidoamine (PAMAM) dendrimer applications have extended from tumor cells to multidrug-resistant tumor cells. However, their transportation in multidrug-resistant tumor cells remains unclear.
Jie Zhang, Mingjuan Li, Mingyue Wang, Hang Xu, Zhuoxiang Wang, Yue Li, Baoyue Ding, Jianqing Gao   +7 more
doaj   +1 more source

The pair ceramide 1-phosphate/ceramide kinase regulates intracellular calcium and progesterone-induced human sperm acrosomal exocytosis

Frontiers in Cell and Developmental Biology, 2023
Before fertilization, spermatozoa must undergo calcium-regulated acrosome exocytosis in response to physiological stimuli such as progesterone and zona pellucida.
Cintia C. Vaquer, Laila Suhaiman, Laila Suhaiman, Martín A. Pavarotti, Rodolfo J. Arias, Rodolfo J. Arias, Anahí B. Pacheco Guiñazú, Gerardo A. De Blas, Gerardo A. De Blas, Silvia A. Belmonte, Silvia A. Belmonte   +10 more
doaj   +1 more source

SNAP23 Regulates Endothelial Exocytosis of von Willebrand Factor. [PDF]

PLoS ONE, 2015
Endothelial exocytosis regulates vascular thrombosis and inflammation. The trafficking and release of endothelial vesicles is mediated by SNARE (Soluble NSF Attachment protein REceptors) molecules, but the exact identity of endothelial SNAREs has been ...
Qiuyu Martin Zhu, Munekazu Yamakuchi, Charles J Lowenstein   +2 more
doaj   +1 more source

Exocytosis of serotonin from the neuronal soma is sustained by a serotonin and calcium-dependent feedback loop

Frontiers in Cellular Neuroscience, 2014
The soma of many neurons releases large amounts of transmitter molecules through an exocytosis process that continues for hundreds of seconds after the end of the triggering stimulus.
Carolina eLeon-Pinzon, Montserrat G. Cercós, Paula eNoguez, Citlali eTrueta, Francisco eF. De-Miguel   +4 more
doaj   +1 more source

An inhibitory effect of extracellular Ca2+ on Ca2+-dependent exocytosis. [PDF]

PLoS ONE, 2011
AIM: Neurotransmitter release is elicited by an elevation of intracellular Ca(2+) concentration ([Ca(2+)](i)). The action potential triggers Ca(2+) influx through Ca(2+) channels which causes local changes of [Ca(2+)](i) for vesicle release. However, any
Wei Xiong, Tao Liu, Yeshi Wang, Xiaowei Chen, Lei Sun, Ning Guo, Hui Zheng, Lianghong Zheng, Martial Ruat, Weiping Han, Claire Xi Zhang, Zhuan Zhou   +11 more
doaj   +1 more source

Extrasynaptic exocytosis and its mechanisms: a source of molecules mediating volume transmission in the nervous system

Frontiers in Physiology, 2012
We review the evidence of exocytosis from extrasynaptic sites in the soma, dendrites and axonal varicosities of central and peripheral neurons of vertebrates and invertebrates, and how it may contribute to signaling in the nervous system.
Citlali eTrueta, Francisco Fernandez De-Miguel   +1 more
doaj   +1 more source

Temperature-dependence of Weibel-Palade body exocytosis and cell surface dispersal of von Willebrand factor and its propolypeptide.

PLoS ONE, 2011
BackgroundWeibel-Palade bodies (WPB) are endothelial cell (EC) specific secretory organelles containing Von Willebrand factor (VWF). The temperature-dependence of Ca(2+)-driven WPB exocytosis is not known, although indirect evidence suggests that WPB ...
Lindsay Hewlett, Gregor Zupančič, Gregory Mashanov, Laura Knipe, David Ogden, Matthew J Hannah, Tom Carter   +6 more
doaj   +1 more source

Munc13 mediates klotho-inhibitable diacylglycerol-stimulated exocytotic insertion of pre-docked TRPC6 vesicles.

PLoS ONE, 2020
α-Klotho is a type 1 transmembrane protein that exhibits aging suppression function. The large amino-terminal extracellular domain of α-klotho is shed as soluble klotho (sKlotho) and functions as a circulating cardioprotective hormone.
Jian Xie, Sung-Wan An, Xin Jin, Yuan Gui, Chou-Long Huang   +4 more
doaj   +1 more source