Results 1 to 10 of about 14,388 (200)
Extrasynaptic Communication [PDF]
Frontiers in Molecular Neuroscience, 2021 Streams of action potentials or long depolarizations evoke a massive exocytosis of transmitters and peptides from the surface of dendrites, axons and cell bodies of different neuron types.
FRANCISCO F De-Miguel +2 more
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Distribution of Extrasynaptic NMDA Receptors on Neurons [PDF]
The Scientific World Journal, 2012 NMDA receptors are found in both synaptic and extrasynaptic locations on neurons. NMDA receptors also can be found on neurons in early stages prior to synaptogenesis, where they may be involved in migration and differentiation.
Ronald S. Petralia
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Tau is required for the function of extrasynaptic NMDA receptors [PDF]
Scientific Reports, 2019 Tau is a microtubule-associated neuronal protein found mainly in axons. However, increasing evidence indicates that it is also present in dendrites, where it serves as an essential mediator of synaptic NMDA (N-methyl-D-aspartate) receptor-dependent ...
Noemí Pallas-Bazarra +4 more
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Extrasynaptic Neurotransmission in the Modulation of Brain Function. Focus on the Striatal Neuronal–Glial Networks [PDF]
Frontiers in Physiology, 2012 Extrasynaptic neurotransmission is an important short distance form of volume transmission (VT) and describes the extracellular diffusion of transmitters and modulators after synaptic spillover or extrasynaptic release in the local circuit regions ...
Kjell Fuxe +2 more
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Frontiers in Physiology, 2012 We review the evidence of exocytosis from extrasynaptic sites in the soma, dendrites and axonal varicosities of central and peripheral neurons of vertebrates and invertebrates, and how it may contribute to signaling in the nervous system.
Citlali Trueta, FRANCISCO F De-Miguel
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Frontiers in Synaptic Neuroscience, 2018 This review article deals with the mechanisms of extrasynaptic release of transmitter substances, namely the release from the soma, axon and dendrites in the absence of postsynaptic counterparts.
Elaine Del-Bel +2 more
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The role of spinal cord extrasynaptic α 5 GABA A receptors in chronic pain
Physiological Reports, 2021 Chronic pain is an incapacitating condition that affects a large population worldwide. Until now, there is no drug treatment to relieve it. The impairment of GABAergic inhibition mediated by GABAA receptors (GABAAR) is considered a relevant factor in ...
Rodolfo Delgado-Lezama +2 more
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A quantitative method to assess extrasynaptic NMDA receptor function in the protective effect of synaptic activity against neurotoxicity [PDF]
BMC Neuroscience, 2008 Background Extrasynaptic NMDA receptors couple to a CREB shut-off pathway and cause cell death, whereas synaptic NMDA receptors and nuclear calcium signaling promote CREB-mediated transcription and neuronal survival.
Bading Hilmar +2 more
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Re-Evaluation of the Ultrastructural Localization of Tonic GABA-A Receptors [PDF]
PharmaceuticalsCell membrane receptors play key roles in physiological and pathological processes, yet the mechanisms governing their expression and distribution across the plasma membrane remain not completely understood. Broadly, membrane receptors can be categorized
Abraham Rosas-Arellano
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Rapid homeostatic downregulation of LTP by extrasynaptic GluN2B receptors [PDF]
Journal of Neurophysiology, 2018 Although the activation of extrasynaptic GluN2B-containing N-methyl-D-aspartate (NMDA) receptors has been implicated in neurodegenerative diseases, such as Alzheimer's and Huntington's disease, their physiological function remains unknown. In this study,
Jary Y Delgado +2 more
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