Results 11 to 20 of about 12,399 (169)
Metabotropic Regulation of Extrasynaptic GABAA Receptors [PDF]
Frontiers in Neural Circuits, 2013 A large body of work now shows the importance of GABAA receptor-mediated tonic inhibition in regulating CNS function. However, outside of pathological conditions, there is relatively little evidence that the magnitude of tonic inhibition is itself under ...
William Martin Connelly +3 more
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Distribution of Extrasynaptic NMDA Receptors on Neurons [PDF]
The Scientific World Journal, 2012 NMDA receptors are found in both synaptic and extrasynaptic locations on neurons. NMDA receptors also can be found on neurons in early stages prior to synaptogenesis, where they may be involved in migration and differentiation.
Ronald S. Petralia
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Extrasynaptic δ-subunit containing GABAA receptors [PDF]
Journal of Integrative Neuroscience, 2021 γ-Aminobutyric acid type A receptors (GABAARs) are GABA gated heteropentameric chloride channels responsible for the adult brain’s primary inhibition.
Ayla Arslan
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Tau is required for the function of extrasynaptic NMDA receptors [PDF]
Scientific Reports, 2019 Tau is a microtubule-associated neuronal protein found mainly in axons. However, increasing evidence indicates that it is also present in dendrites, where it serves as an essential mediator of synaptic NMDA (N-methyl-D-aspartate) receptor-dependent ...
Noemí Pallas-Bazarra +4 more
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Optochemical profiling of NMDAR molecular diversity at synaptic and extrasynaptic sites [PDF]
The EMBO JournalNeurotransmitter receptors are critical for neuronal communication. They often form large multimeric complexes that differ in their subunit composition, distribution, and signaling properties. N‐methyl‐D‐aspartate receptors (NMDARs), a class of glutamate-
Antoine Sicard +9 more
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Non-Neuronal Acetylcholinesterase Activity Shows Limited Utility for Early Detection of Sepsis
Biomedicines, 2023 (1) Background: Sepsis is a severe systemic inflammatory condition characterized by rapid clinical deterioration and organ dysfunction. The cholinergic system has been implicated in modulating the inflammatory response.
Aleksandar R. Zivkovic +5 more
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Frontiers in Cellular Neuroscience, 2022 Rapid increases in cell volume reduce the size of the extracellular space (ECS) and are associated with elevated brain tissue excitability. We recently demonstrated that astrocytes, but not neurons, rapidly swell in elevated extracellular potassium (∧[K+]
Erin Walch +12 more
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Regulating anxiety with extrasynaptic inhibition [PDF]
Nature Neuroscience, 2015 Aversive experiences can lead to complex behavioral adaptations including increased levels of anxiety and fear generalization. The neuronal mechanisms underlying such maladaptive behavioral changes, however, are poorly understood. Here, using a combination of behavioral, physiological and optogenetic approaches in mouse, we identify a specific ...
Botta P. +13 more
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Extrasynaptic neuron-glia communication [PDF]
Communicative & Integrative Biology, 2011 Chemical synaptic transmission between neurons is believed to take place at specialized sites of cell contact, comprising presynaptic terminals and postsynaptic membranes. Neurotransmitter release has been shown to occur also extrasynaptically, mainly targeting glial cells. In a recent study, we investigated the mechanism of extrasynaptic glutamate and
Christian, Lohr +2 more
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Frontiers in Molecular Neuroscience, 2008 Glycine and GABA mediate inhibitory neurotransmission in the spinal cord and central nervous system. The general concept of neurotransmission is now challenged by the contribution of both phasic activation of postsynaptic glycine and GABAA receptors ...
Emilie Muller +3 more
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