Results 11 to 20 of about 14,388 (200)
Metabotropic Regulation of Extrasynaptic GABAA Receptors [PDF]
Frontiers in Neural Circuits, 2013 A large body of work now shows the importance of GABAA receptor-mediated tonic inhibition in regulating CNS function. However, outside of pathological conditions, there is relatively little evidence that the magnitude of tonic inhibition is itself under ...
William Martin Connelly +3 more
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Cerebellar Cortex: Computation by Extrasynaptic Inhibition? [PDF]
Current Biology, 2002 In the cerebellar cortex, inhibitory inputs to granule cells exhibit prominent tonic and spillover components resulting from the activation of extrasynaptic receptors.
De Schutter, Erik, Erik De Schutter
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Extrasynaptic δ-subunit containing GABAA receptors [PDF]
Journal of Integrative Neuroscience, 2021 γ-Aminobutyric acid type A receptors (GABAARs) are GABA gated heteropentameric chloride channels responsible for the adult brain’s primary inhibition.
Ayla Arslan
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Modulating anxiety with extrasynaptic inhibition [PDF]
, 2014 Traumatic experiences and stress can lead to complex behavioral adaptations, including increased levels of anxiety and fear generalization. The neuronal mechanisms underlying such maladaptive behavioral changes are, however, poorly understood.
Botta, Paolo
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GLP-1 selectively enhances tonic GABAA receptor-mediated currents in mouse dentate gyrus granule cells of the ventral hippocampus [PDF]
Frontiers in Cellular NeuroscienceGlucagon-like peptide-1 (GLP-1) is a metabolic hormone secreted by L-cells in the gut and it stimulates insulin secretion in the pancreatic islets by activating GLP-1 receptors (GLP-1Rs).
Olga Netsyk +3 more
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GABA Potency at GABAA Receptors Found in Synaptic and Extrasynaptic Zones
Frontiers in Cellular Neuroscience, 2012 The potency of GABA is vitally important for its primary role in activating GABAA receptors and acting as an inhibitory neurotransmitter. Although numerous laboratories have presented information, directly or indirectly, on GABA potency, it is often ...
Martin Mortensen +2 more
exaly +3 more sources
DMV extrasynaptic NMDA receptors regulate caloric intake in rats
JCI Insight, 2021 Acute high-fat diet (aHFD) exposure induces a brief period of hyperphagia before caloric balance is restored. Previous studies have demonstrated that this period of regulation is associated with activation of synaptic N-methyl-D-aspartate (NMDA ...
Courtney Clyburn +3 more
doaj +2 more sources
Neurobiology of Disease, 2012 We recently reported evidence for disturbed synaptic versus extrasynaptic NMDAR transmission in the early pathogenesis of Huntington's disease (HD), a late-onset neurodegenerative disorder caused by CAG repeat expansion in the gene encoding huntingtin ...
Austen J Milnerwood +2 more
exaly +3 more sources
Astrocytic actions on extrasynaptic neuronal currents [PDF]
Frontiers in Cellular Neuroscience, 2015 In the last few decades, knowledge about astrocytic functions has significantly increased. It was demonstrated that astrocytes are not passive elements of the central nervous system, but active partners of neurons.
Balázs Pál, Balazs ePal
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Extrasynaptic vesicle recycling in mature hippocampal neurons [PDF]
Nature Communications, 2011 Fast neuronal signalling relies on highly regulated vesicle fusion and recycling at specialized presynaptic terminals. Recently, examples of non-classical neurotransmission have also been reported, where fusion of vesicles can occur at sites remote from ...
Staras, Kevin +11 more
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