Results 31 to 40 of about 15,145 (185)

Extrasynaptic glycine receptors of rodent dorsal raphe serotonergic neurons:a sensitive target for ethanol [PDF]

, 2014
Alcohol abuse is a significant medical and social problem. Several neurotransmitter systems are implicated in ethanol's actions, with certain receptors and ion channels emerging as putative targets.
Corteen, Nicole, Mitchell, Elizabeth A., Swinny, Jerome, Elizabeth A Mitchell, Lambert, Jeremy J., Jerome D Swinny, Scott J Greig, Edward P Maguire, Maguire, Edward P., Jeremy J Lambert, Nicole Corteen, Swinny, Jerome D., Delia Belelli, Greig, Scott J., David J K Balfour, Balfour, David J. K., Belelli, Delia   +16 more
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Extrasynaptic NMDA Receptor in Excitotoxicity [PDF]

The Neuroscientist, 2014
It is generally accepted that proper activation of N-methyl-d-aspartate receptors (NMDARs) promotes neuronal survival and supports neuroplasticity, and excessive NMDAR activation leads to pathological outcomes and neurodegeneration. As NMDARs are found at both synaptic and extrasynaptic sites, there is significant interest in determining how NMDARs at ...
Xianju, Zhou, Zhuoyou, Chen, Wenwei, Yun, Jianhua, Ren, Chengwei, Li, Hongbing, Wang   +5 more
openaire   +2 more sources

Synaptic and extrasynaptic NMDA receptors are gated by different endogenous coagonists. [PDF]

, 2012
N-methyl-D-aspartate receptors (NMDARs) are located in neuronal cell membranes at synaptic and extrasynaptic locations, where they are believed to mediate distinct physiological and pathological processes.
Papouin, Thomas, Mothet, J. P., Ruel, Jérôme, Ladépêche, L., POLLEGIONI, LOREDANO, SACCHI, SILVIA, Hanini, Marwa, Hanini, M., Ladépêche, Laurent, Labasque, M., Oliet, S. H., Labasque, Marilyne, Oliet, Stéphane H.R., Groc, Laurent, Mothet, Jean-Pierre, Ruel, J., Groc, L., Papouin, T.   +17 more
core   +2 more sources

Astrocytic Actions on Extrasynaptic Neuronal Currents [PDF]

Frontiers in Cellular Neuroscience, 2015
In the last few decades, knowledge about astrocytic functions has significantly increased. It was demonstrated that astrocytes are not passive elements of the central nervous system (CNS), but active partners of neurons. There is a growing body of knowledge about the calcium excitability of astrocytes, the actions of different gliotransmitters and ...
openaire   +3 more sources

A Jacob/nsmf gene knockout does not protect against acute hypoxia- and NMDA-induced excitotoxic cell death

Molecular Brain, 2023
Jacob is a synapto-nuclear messenger protein that encodes and transduces the origin of synaptic and extrasynaptic NMDA receptor signals to the nucleus. The protein assembles a signalosome that differs in case of synaptic or extrasynaptic NMDAR activation.
Guilherme M. Gomes, Julia Bär, Anna Karpova, Michael R. Kreutz   +3 more
doaj   +1 more source

Extrasynaptic GABAA receptors and the local regulation of sleep [PDF]

, 2012
GABA (γ-aminobutyric acid) is the main inhibitory transmitter in the mammalian brain. Recent studies emphasise the importance of extrasynaptic GABAA receptors (i.e., GABAA-Rs located outside the synapse) in controlling the excitability of local neuronal ...
Winsky-Sommerer, Raphaelle, Yasenkov, Roman   +1 more
core   +1 more source

Oligomerization and cell surface expression of recombinant GABAA receptors tagged in the δ subunit

Journal of Integrative Neuroscience, 2019
The γ-Aminobutyric acid type A receptors (GABAARs) are heteropentameric chloride channels responsible for primary inhibition in the mammalian brain.
Furkan Enes Oflaz, Çağdaş Devrim Son, Ayla Arslan   +2 more
doaj   +1 more source

Cocaine-Induced Synaptic Redistribution of NMDARs in Striatal Neurons Alters NMDAR-Dependent Signal Transduction

Frontiers in Neuroscience, 2020
The consequence of repeated cocaine exposure and prolonged abstinence on glutamate receptor expression in the nucleus accumbens has been extensively studied. However, the early effects of cocaine on NMDAR signaling remain unknown. NMDAR signaling depends
Ilse Delint-Ramirez, Amir Segev, Asha Pavuluri, David W. Self, Saïd Kourrich, Saïd Kourrich   +5 more
doaj   +1 more source

Glutamate-Mediated Extrasynaptic Inhibition [PDF]

Neuron, 2001
Abstract NMDA receptors (NMDARs) typically contribute to excitatory synaptic transmission in the CNS. While Ca 2+ influx through NMDARs plays a critical role in synaptic plasticity, direct actions of NMDAR-mediated Ca 2+ influx on neuronal excitability have not been well established. Here we show that Ca 2+ influx through NMDARs is directly coupled
Isaacson, Jeffry S., Murphy, Gabe J.
openaire   +1 more source

GABA-Independent GABAA Receptor Openings Maintain Tonic Currents [PDF]

, 2013
Activation of GABAA receptors (GABAARs) produces two forms of inhibition: ‘phasic’ inhibition generated by the rapid, transient activation of synaptic GABAARs by presynaptic GABA release, and tonic inhibition generated by the persistent activation of ...
Herd, Murray B, Belelli, D., Wlodarczyk, A. I., Sylantyev, S., Linthorst, Astrid C.E., Walker, Matthew C., Walker, M. C., Rusakov, Dmitri A, Lambert, Jeremy J, Wlodarczyk, Agnieszka I., Kersanté, Flavie, Walker, Matthew C, Semyanov, A., Semyanov, Alexey, Rusakov, Dmitri A., Rusakov, D. A., Herd, Murray B., Linthorst, A. C. E., Lambert, Jeremy J., Pavlov, I., Linthorst, Astrid C E, Lambert, J. J., Herd, M. B., Kersante, F., Wlodarczyk, Agnieszka I, Pavlov, Ivan, Sylantyev, Sergiy, Belelli, Delia   +27 more
core   +1 more source