Results 31 to 40 of about 14,388 (200)

Organization of NMDA receptors at extrasynaptic locations [PDF]

Neuroscience, 2010
NMDA receptors are found in neurons both at synapses and in extrasynaptic locations. Extrasynaptic locations are poorly characterized. Here we used preembedding immunoperoxidase and postembedding immunogold electron microscopy and fluorescence light microscopy to characterize extrasynaptic NMDA receptor locations in dissociated hippocampal neurons in ...
R S, Petralia, Y X, Wang, F, Hua, Z, Yi, A, Zhou, L, Ge, F A, Stephenson, R J, Wenthold   +7 more
openaire   +2 more sources

Reduction in focal ictal activity following transplantation of MGE interneurons requires expression of the GABA(A) receptor α4 subunit

Frontiers in Cellular Neuroscience, 2015
Despite numerous advances, treatment-resistant seizures remain an important problem. Loss of neuronal inhibition is present in a variety of epilepsy models and is suggested as a mechanism for increased excitability, leading to the proposal that grafting ...
Manoj K. Jaiswal, Sotirios A Keros, Mingrui A Zhao, Mingrui A Zhao, Melis eInan, Theodore H Schwartz, Theodore H Schwartz, Stewart A Anderson, Gregg E Homanics, Peter A. Goldstein   +9 more
doaj   +1 more source

Imaging extrasynaptic glutamate dynamics in the brain [PDF]

Proceedings of the National Academy of Sciences, 2009
Glutamate is the major neurotransmitter in the brain, mediating point-to-point transmission across the synaptic cleft in excitatory synapses. Using a glutamate imaging method with fluorescent indicators, we show that synaptic activity generates extrasynaptic glutamate dynamics in the vicinity of active synapses.
Yohei, Okubo, Hiroshi, Sekiya, Shigeyuki, Namiki, Hirokazu, Sakamoto, Sho, Iinuma, Miwako, Yamasaki, Masahiko, Watanabe, Kenzo, Hirose, Masamitsu, Iino   +8 more
openaire   +2 more sources

Extrasynaptic glycine receptors of rodent dorsal raphe serotonergic neurons:a sensitive target for ethanol [PDF]

, 2014
Alcohol abuse is a significant medical and social problem. Several neurotransmitter systems are implicated in ethanol's actions, with certain receptors and ion channels emerging as putative targets.
Corteen, Nicole, Mitchell, Elizabeth A., Swinny, Jerome, Elizabeth A Mitchell, Lambert, Jeremy J., Jerome D Swinny, Scott J Greig, Edward P Maguire, Maguire, Edward P., Jeremy J Lambert, Nicole Corteen, Swinny, Jerome D., Delia Belelli, Greig, Scott J., David J K Balfour, Balfour, David J. K., Belelli, Delia   +16 more
core   +1 more source

Extrasynaptic NMDA Receptor in Excitotoxicity [PDF]

The Neuroscientist, 2014
It is generally accepted that proper activation of N-methyl-d-aspartate receptors (NMDARs) promotes neuronal survival and supports neuroplasticity, and excessive NMDAR activation leads to pathological outcomes and neurodegeneration. As NMDARs are found at both synaptic and extrasynaptic sites, there is significant interest in determining how NMDARs at ...
Xianju, Zhou, Zhuoyou, Chen, Wenwei, Yun, Jianhua, Ren, Chengwei, Li, Hongbing, Wang   +5 more
openaire   +2 more sources

Organization of Astrocytic GLT-1 at Cortical Inhibitory Synapses. [PDF]

Glia
GLT‐1+ ALs frequently juxtapose symmetric synapses. Distance‐based phenotyping identifies symmetric‐ and asymmetric‐associated GLT‐1+ ALs. Distal inhibitory synapses show enriched GLT‐1/α2 couples in ALs within 1000 nm, conserved in human cortex. ABSTRACT Glutamate spillover from excitatory synapses modulates neighboring inhibitory synapses, yet the ...
Melone M, Di Palma M, Scimemi A, Conti F.   +3 more
europepmc   +2 more sources

Glutamate-Mediated Extrasynaptic Inhibition [PDF]

Neuron, 2001
Abstract NMDA receptors (NMDARs) typically contribute to excitatory synaptic transmission in the CNS. While Ca 2+ influx through NMDARs plays a critical role in synaptic plasticity, direct actions of NMDAR-mediated Ca 2+ influx on neuronal excitability have not been well established. Here we show that Ca 2+ influx through NMDARs is directly coupled
Isaacson, Jeffry S., Murphy, Gabe J.
openaire   +1 more source

Local Chemical Gradients in a Mammalian Cortex Measured In Vivo With a Silicon Nanodialysis Mass Spectrometry Platform

Angewandte Chemie, EarlyView.
Fluorescence image of the coronal slice of mouse brain where multiple neurochemicals have been measured in vivo with a nanodialysis platform coupled to CE‐MS to reveal strong millimeter‐scale spatial chemical gradients. Formation and maintenance of such local chemical compartments in the otherwise diffusion‐homogeneous cortex indicates strong ...
Weihua Shi, Keyin Li, Yu Ding, Alex G. Armstrong, Jonathan V. Sweedler, Yurii Vlasov   +5 more
wiley   +2 more sources

A Jacob/nsmf gene knockout does not protect against acute hypoxia- and NMDA-induced excitotoxic cell death

Molecular Brain, 2023
Jacob is a synapto-nuclear messenger protein that encodes and transduces the origin of synaptic and extrasynaptic NMDA receptor signals to the nucleus. The protein assembles a signalosome that differs in case of synaptic or extrasynaptic NMDAR activation.
Guilherme M. Gomes, Julia Bär, Anna Karpova, Michael R. Kreutz   +3 more
doaj   +1 more source

Extracellular space diffusion and extrasynaptic transmission

Physiological Research, 2008
The diffusion of neuroactive substances in the extracellular space (ECS) plays an important role in short- and long-distance communication between nerve cells and is the underlying mechanism of extrasynaptic (volume) transmission. The diffusion properties of the ECS are described by three parameters: 1. ECS volume fraction alpha (alpha=ECS volume/total
L, Vargová, E, Syková
openaire   +2 more sources