Dynamical questions in volume transmission
Journal of Biological Dynamics, 2023 In volume transmission (or neuromodulation) neurons do not make one-to-one connections to other neurons, but instead simply release neurotransmitter into the extracellular space from numerous varicosities.
Allison Cruikshank +3 more
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The Nature of Noradrenergic Volume Transmission From Locus Coeruleus to Brainstem Mesencephalic Trigeminal Sensory Neurons [PDF]
Frontiers in Cellular Neuroscience, 2022 Noradrenergic neurons in the locus coeruleus (LC) release noradrenaline (NA) that acts via volume transmission to activate extrasynaptic G-protein coupled receptors (GPCRs) in target cells throughout the brain.
Hiroki Toyoda +14 more
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Brain Dopamine Transmission in Health and Parkinson's Disease: Modulation of Synaptic Transmission and Plasticity Through Volume Transmission and Dopamine Heteroreceptors [PDF]
Frontiers in Synaptic Neuroscience, 2018 This perspective article provides observations supporting the view that nigro-striatal dopamine neurons and meso-limbic dopamine neurons mainly communicate through short distance volume transmission in the um range with dopamine diffusing into ...
Dasiel O. Borroto-Escuela +17 more
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Astrocytes Amplify Neuronal Dendritic Volume Transmission Stimulated by Norepinephrine [PDF]
Cell Reports, 2019 Summary: In addition to their support role in neurotransmitter and ion buffering, astrocytes directly regulate neurotransmission at synapses via local bidirectional signaling with neurons.
Chun Chen +5 more
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Wiring and Volume Transmission: An Overview of the Dual Modality for Serotonin Neurotransmission [PDF]
ACS Chemical Neuroscience, 2023 Serotonin is a neurotransmitter involved in the modulation of a multitude of physiological and behavioral processes. In spite of the relatively reduced number of serotonin-producing neurons present in the mammalian CNS, a complex long-range projection ...
Massimo Pasqualetti
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Volume Transmission and Pain Perception [PDF]
The Scientific World Journal, 2003 Volume transmission (VT) is the diffusion through the brain extracellular fluid of neurotransmitters released at points that may be remote from the target cells with the resulting activation of extrasynaptic receptors.
Gilberto C. Castañeda-Hernàndez +1 more
doaj +4 more sources
Control of Feeding Behavior by Cerebral Ventricular Volume Transmission of Melanin-Concentrating Hormone [PDF]
Cell Metabolism, 2018 Summary Classical mechanisms through which brain-derived molecules influence behavior include neuronal synaptic communication and neuroendocrine signaling.
Vaibhav R Konanur +2 more
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Volume transmission of beta-endorphin via the cerebrospinal fluid; a review [PDF]
Fluids and Barriers of the CNS, 2012 There is increasing evidence that non-synaptic communication by volume transmission in the flowing CSF plays an important role in neural mechanisms, especially for extending the duration of behavioral effects.
Veening Jan G +2 more
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The role of transmitter diffusion and flow versus extracellular vesicles in volume transmission in the brain neural–glial networks [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2015 Kjell Fuxe +2 more
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Frontiers in Neural Circuits, 2021 Sensory systems have to be malleable to context-dependent modulations occurring over different time scales, in order to serve their evolutionary function of informing about the external world while also eliciting survival-promoting behaviors. Stress is a
Sara Pagella +2 more
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