Results 1 to 10 of about 1,793,673 (287)

Brain Dopamine Transmission in Health and Parkinson's Disease: Modulation of Synaptic Transmission and Plasticity Through Volume Transmission and Dopamine Heteroreceptors [PDF]

Frontiers in Synaptic Neuroscience, 2018
This perspective article provides observations supporting the view that nigro-striatal dopamine neurons and meso-limbic dopamine neurons mainly communicate through short distance volume transmission in the um range with dopamine diffusing into ...
Dasiel O. Borroto-Escuela, Dasiel O. Borroto-Escuela, Dasiel O. Borroto-Escuela, Miguel Perez De La Mora, Paul Manger, Manuel Narváez, Sarah Beggiato, Minerva Crespo-Ramírez, Gemma Navarro, Karolina Wydra, Zaida Díaz-Cabiale, Alicia Rivera, Luca Ferraro, Sergio Tanganelli, Małgorzata Filip, Rafael Franco, Rafael Franco, Kjell Fuxe   +17 more
doaj   +4 more sources

Astrocytes Amplify Neuronal Dendritic Volume Transmission Stimulated by Norepinephrine [PDF]

Cell Reports, 2019
Summary: In addition to their support role in neurotransmitter and ion buffering, astrocytes directly regulate neurotransmission at synapses via local bidirectional signaling with neurons.
Chun Chen, ZhiYing Jiang, Xin Fu, Diankun Yu, Hai Huang, Jeffrey G. Tasker   +5 more
doaj   +5 more sources

The Nature of Noradrenergic Volume Transmission From Locus Coeruleus to Brainstem Mesencephalic Trigeminal Sensory Neurons [PDF]

Frontiers in Cellular Neuroscience, 2022
Noradrenergic neurons in the locus coeruleus (LC) release noradrenaline (NA) that acts via volume transmission to activate extrasynaptic G-protein coupled receptors (GPCRs) in target cells throughout the brain.
Hiroki Toyoda, Jonghwa Won, Jonghwa Won, Wheedong Kim, Hayun Kim, Oscar Davy, Mitsuru Saito, Doyun Kim, Takuma Tanaka, Youngnam Kang, Youngnam Kang, Youngnam Kang, Seog Bae Oh, Seog Bae Oh, Seog Bae Oh   +14 more
doaj   +2 more sources

Mechanisms of neuromodulatory volume transmission. [PDF]

Mol Psychiatry
AbstractA wealth of neuromodulatory transmitters regulate synaptic circuits in the brain. Their mode of signaling, often called volume transmission, differs from classical synaptic transmission in important ways. In synaptic transmission, vesicles rapidly fuse in response to action potentials and release their transmitter content.
Özçete ÖD, Banerjee A, Kaeser PS.
europepmc   +3 more sources

Volume transmission signalling via astrocytes. [PDF]

Philos Trans R Soc Lond B Biol Sci, 2014
The influence of astrocytes on synaptic function has been increasingly studied, owing to the discovery of both gliotransmission and morphological ensheathment of synapses. While astrocytes exhibit at best modest membrane potential fluctuations, activation of G-protein coupled receptors (GPCRs) leads to a prominent elevation of intracellular calcium ...
Hirase H, Iwai Y, Takata N, Shinohara Y, Mishima T.   +4 more
europepmc   +4 more sources

<i>Ascaris suum</i> Informs Extrasynaptic Volume Transmission in Nematodes. [PDF]

ACS Chem Neurosci, 2021
Neural circuit synaptic connectivities (the connectome) provide the anatomical foundation for our understanding of nematode nervous system function. However, other nonsynaptic routes of communication are known in invertebrates including extrasynaptic volume transmission (EVT), which enables short- and/or long-range communication in the absence of ...
Atkinson LE, Liu Y, McKay F, Vandewyer E, Viau C, Irvine A, Rosa BA, Li Z, Liang Q, Marks NJ, Maule AG, Mitreva M, Beets I, Li L, Mousley A.   +14 more
europepmc   +7 more sources

Dynamical questions in volume transmission

Journal of Biological Dynamics, 2023
In volume transmission (or neuromodulation) neurons do not make one-to-one connections to other neurons, but instead simply release neurotransmitter into the extracellular space from numerous varicosities.
Allison Cruikshank, H. Frederik Nijhout, Janet Best, Michael Reed   +3 more
doaj   +3 more sources

Volume Transmission and Pain Perception [PDF]

The Scientific World Journal, 2003
Volume transmission (VT) is the diffusion through the brain extracellular fluid of neurotransmitters released at points that may be remote from the target cells with the resulting activation of extrasynaptic receptors.
Gilberto C. Castañeda-Hernàndez, Paul Bach-y-Rita   +1 more
doaj   +3 more sources

Astrocytes and extracellular matrix in extrasynaptic volume transmission. [PDF]

Philos Trans R Soc Lond B Biol Sci, 2014
Volume transmission is a form of intercellular communication that does not require synapses; it is based on the diffusion of neuroactive substances across the brain extracellular space (ECS) and their binding to extrasynaptic high-affinity receptors on neurons or glia.
Vargová L, Syková E.
europepmc   +4 more sources

Volume transmission of beta-endorphin via the cerebrospinal fluid; a review [PDF]

Fluids and Barriers of the CNS, 2012
There is increasing evidence that non-synaptic communication by volume transmission in the flowing CSF plays an important role in neural mechanisms, especially for extending the duration of behavioral effects.
Veening Jan G, Gerrits Peter O, Barendregt Henk P   +2 more
doaj   +2 more sources