Results 1 to 10 of about 169,723 (160)

A theory of synaptic transmission [PDF]

eLife, 2021
Rapid and precise neuronal communication is enabled through a highly synchronous release of signaling molecules neurotransmitters within just milliseconds of the action potential.
Bin Wang, Olga K Dudko
doaj   +3 more sources

Cell-autonomous GABAARs are essential for NMDAR-mediated synaptic transmission, LTP, and spatial memory [PDF]

EMBO Reports
GABAA receptors (GABAARs) mediate most synaptic inhibition in the brain, but their cell-autonomous role in regulating glutamatergic transmission remains poorly understood.
Jing-jing Duan, Bin Jiang, Wei Yin, Yuan Lin, Guang-mei Yan, Wei Lu   +5 more
doaj   +2 more sources

Retraction Note: Reprogramming glioblastoma multiforme cells into neurons by protein kinase inhibitors

Journal of Experimental & Clinical Cancer Research, 2021
This article has been retracted.
Jie Yuan, Fan Zhang, Dennis Hallahan, Zhen Zhang, Liming He, Ling-Gang Wu, Meng You, Qin Yang   +7 more
doaj   +1 more source

The role of thrombin in early-onset seizures

Frontiers in Cellular Neuroscience, 2023
A variety of clinical observations and studies in animal models of temporal lobe epilepsy (TLE) reveal dysfunction of blood-brain barrier (BBB) during seizures.
Alina Savotchenko, Mariia Klymenko, Mariia Shypshyna, Dmytro Isaev   +3 more
doaj   +1 more source

A Common Human Brain-Derived Neurotrophic Factor Polymorphism Leads to Prolonged Depression of Excitatory Synaptic Transmission by Isoflurane in Hippocampal Cultures

Frontiers in Molecular Neuroscience, 2022
Multiple presynaptic and postsynaptic targets have been identified for the reversible neurophysiological effects of general anesthetics on synaptic transmission and neuronal excitability. However, the synaptic mechanisms involved in persistent depression
Riley A. Williams, Kenneth W. Johnson, Francis S. Lee, Francis S. Lee, Francis S. Lee, Hugh C. Hemmings, Hugh C. Hemmings, Jimcy Platholi, Jimcy Platholi   +8 more
doaj   +1 more source

An ex vivo Model of Paired Cultured Hippocampal Neurons for Bi-directionally Studying Synaptic Transmission and Plasticity

Bio-Protocol, 2023
Synapses provide the main route of signal transduction within neuronal networks. Many factors regulate critical synaptic functions. These include presynaptic calcium channels, triggering neurotransmitter release, and postsynaptic ionotropic receptors ...
Ruslan Stanika, Gerald Obermair
doaj   +1 more source

Turbocharging synaptic transmission

FEBS Letters, 2023
Evidence from biochemistry, genetics, and electron microscopy strongly supports the idea that a ring of Synaptotagmin is central to the clamping and release of synaptic vesicles (SVs) for synchronous neurotransmission. Recent direct measurements in cell‐free systems suggest there are 12 SNAREpins in each ready‐release vesicle, consisting of six ...
James E. Rothman, Kirill Grushin, Manindra Bera, Frederic Pincet   +3 more
openaire   +3 more sources

Unveiling the Synaptic Function and Structure Using Paired Recordings From Synaptically Coupled Neurons

Frontiers in Synaptic Neuroscience, 2020
Synaptic transmission between neurons is the basic mechanism for information processing in cortical microcircuits. To date, paired recording from synaptically coupled neurons is the most widely used method which allows a detailed functional ...
Guanxiao Qi, Danqing Yang, Chao Ding, Dirk Feldmeyer, Dirk Feldmeyer, Dirk Feldmeyer   +5 more
doaj   +1 more source

Chronic Ethanol Exposure Enhances Facial Stimulation-Evoked Mossy Fiber–Granule Cell Synaptic Transmission via GluN2A Receptors in the Mouse Cerebellar Cortex

Frontiers in Systems Neuroscience, 2021
Sensory information is transferred to the cerebellar cortex via the mossy fiber–granule cell (MF–GC) pathway, which participates in motor coordination and motor learning.
Bing-Xue Li, Bing-Xue Li, Guang-Hui Dong, Guang-Hui Dong, Hao-Long Li, Hao-Long Li, Jia-Song Zhang, Jia-Song Zhang, Yan-Hua Bing, Chun-Ping Chu, Chun-Ping Chu, Song-Biao Cui, De-Lai Qiu, De-Lai Qiu   +13 more
doaj   +1 more source

Reprogramming glioblastoma multiforme cells into neurons by protein kinase inhibitors

Journal of Experimental & Clinical Cancer Research, 2018
Background Reprogramming of cancers into normal-like tissues is an innovative strategy for cancer treatment. Recent reports demonstrate that defined factors can reprogram cancer cells into pluripotent stem cells. Glioblastoma multiforme (GBM) is the most
Jie Yuan, Fan Zhang, Dennis Hallahan, Zhen Zhang, Liming He, Ling-Gang Wu, Meng You, Qin Yang   +7 more
doaj   +1 more source