Results 1 to 10 of about 172,530 (266)
Novelty producing synaptic plasticity [PDF]
Proceedings of the 2020 Genetic and Evolutionary Computation Conference Companion, 2020 A learning process with the plasticity property often requires reinforcement signals to guide the process. However, in some tasks (e.g. maze-navigation), it is very difficult (or impossible) to measure the performance of an agent (i.e. a fitness value) to provide reinforcements since the position of the goal is not known.
Anil Yaman +4 more
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Neuromodulation of the feedforward dentate gyrus-CA3 microcircuit
Frontiers in Synaptic Neuroscience, 2016 The feedforward dentate gyrus-CA3 microcircuit in the hippocampus is thought to activate ensembles of CA3 pyramidal cells and interneurons to encode and retrieve episodic memories.
Luke Yuri Prince +3 more
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Frontiers in Physiology, 2021 Duchenne muscular dystrophy (DMD) is a genetic neuromuscular disease characterized by progressive muscle weakness and wasting. Stimulation of AMP-activated protein kinase (AMPK) has been demonstrated to increase muscle function and protect muscle against
Xia Dong +17 more
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Optogenetics and synaptic plasticity [PDF]
Acta Pharmacologica Sinica, 2013 The intricate and complex interaction between different populations of neurons in the brain has imposed limits on our ability to gain detailed understanding of synaptic transmission and its integration when employing classical electrophysiological approaches. Indeed, electrical field stimulation delivered via traditional microelectrodes does not permit
Yu-feng, Xie +2 more
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eLife, 2019 Cannabinoid type one receptor (CB1R) is only stably surface expressed in axons, where it downregulates neurotransmitter release. How this tightly regulated axonal surface polarity is established and maintained is unclear.
Alexandra Fletcher-Jones +5 more
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The epitranscriptome and synaptic plasticity
Current Opinion in Neurobiology, 2019 RNA modifications, collectively referred to as 'the epitranscriptome,' have recently emerged as a pervasive feature of cellular mRNAs which have diverse impacts on gene expression. In the last several years, technological advances improving our ability to identify mRNA modifications, coupled with the discovery of proteins that add and remove these ...
Mathieu N Flamand, Kate D Meyer
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STAR Protocols, 2021 Summary: Here, we detail a surface biotinylation technique used to label surface-expressed proteins in primary neuronal cultures. Surface proteins are labeled with membrane-impermeant Sulfo-NHS-SS-biotin, and isolated by pull-down with streptavidin beads
Jithin D. Nair +2 more
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Imaging synaptic plasticity [PDF]
Molecular Brain, 2011 Over the past decade, the use and development of optical imaging techniques has advanced our understanding of synaptic plasticity by offering the spatial and temporal resolution necessary to examine long-term changes at individual synapses. Here, we review the use of these techniques in recent studies of synaptic plasticity and, in particular, long ...
Padamsey, Z, Emptage, N
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MAGUKs, Synaptic Development, and Synaptic Plasticity [PDF]
The Neuroscientist, 2011 MAGUKs are proteins that act as key scaffolds in surface complexes containing receptors, adhesion proteins, and various signaling molecules. These complexes evolved prior to the appearance of multicellular animals and play key roles in cell-cell intercommunication.
Chan-Ying, Zheng +3 more
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The Candidate Schizophrenia Risk Gene Tmem108 Regulates Glucose Metabolism Homeostasis
Frontiers in Endocrinology, 2021 BackgroundSchizophrenia (SCZ) is a severe psychiatric disease affected by genetic factors and environmental contributors, and premorbid abnormality of glucose metabolism is one of the SCZ characteristics supposed to contribute to the disease’s ...
Jianbo Yu +13 more
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