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Long-term potentiation and long-term depression: a clinical perspective [PDF]
Clinics, 2011 Long-term potentiation and long-term depression are enduring changes in synaptic strength, induced by specific patterns of synaptic activity, that have received much attention as cellular models of information storage in the central nervous system.
Timothy V.P. Bliss, Sam F. Cooke
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Discovery of a β-arrestin-biased CCKBR agonist that blocks CCKBR-dependent long-term potentiation [PDF]
Nature CommunicationsThe CCKBR agonists induce neocortical long-term potentiation of excitatory synaptic transmission and enhance memory formation, while its antagonists weaken the potentiation in the amygdala and alleviate depression-like behaviors.
Heng Shi +14 more
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Long-term potentiation and memory [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2003 Abstract The discovery of long-term potentiation (LTP) transformed research on the neurobiology of learning and memory. This did not happen overnight, but the discovery of an experimentally demonstrable phenomenon reflecting activity-driven neuronal and synaptic plasticity changed discussions about what might underlie learning from ...
Richard G M Morris
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The discovery of long-term potentiation [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2003 Abstract This paper describes circumstances around the discovery of long-term potentiation (LTP). In 1966, I had just begun independent work for the degree of Dr medicinae (PhD) in Per Andersen’s laboratory in Oslo after an eighteen-month apprenticeship with him. Studying the effects of activating the perforant path to dentate granule
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Long-Term Potentiation: The Accidental Discovery. [PDF]
HippocampusABSTRACTLong‐term potentiation (LTP), is a type of synaptic plasticity now considered essential for learning and memory. Here I tell the story of how I accidentally discovered in 1966 in the laboratory of Per Andersen in Oslo, Norway, because I was not looking for it. It just emerged.
Lømo T.
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The Pathway-Selective Dependence of Nitric Oxide for Long-Term Potentiation in the Anterior Cingulate Cortex of Adult Mice [PDF]
BiomedicinesNitric oxide (NO) is a key diffusible messenger in the mammalian brain. It has been proposed that NO may diffuse in retrograde into presynaptic terminals, contributing to the induction of hippocampal long-term potentiation (LTP).
Qi-Yu Chen +3 more
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Involvement of CX3CL1/CX3CR1 signaling in spinal long term potentiation. [PDF]
PLoS ONE, 2015 The long-term potentiation (LTP) of spinal C-fiber-evoked field potentials is considered as a fundamental mechanism of central sensitization in the spinal cord.
Chao Bian +3 more
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European Journal of Cell Biology, 2023 Dendritic spines form the postsynaptic compartment of most excitatory synapses in the vertebrate brain. Morphological changes of dendritic spines contribute to major forms of synaptic plasticity such as long-term potentiation (LTP) or depression (LTD ...
Anika Heinze, Marco B. Rust
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Long-term potentiation in isolated dendritic spines. [PDF]
PLoS ONE, 2009 BACKGROUND:In brain, N-methyl-D-aspartate (NMDA) receptor (NMDAR) activation can induce long-lasting changes in synaptic alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptor (AMPAR) levels.
Amadou T Corera +2 more
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Long-Term Potentiation and Memory [PDF]
Physiological Reviews, 2004 Lynch, MA. Long-Term Potentiation and Memory. Physiol Rev 84: 87–136, 2004; 10.1152/physrev.00014.2003.—One of the most significant challenges in neuroscience is to identify the cellular and molecular processes that underlie learning and memory formation. The past decade has seen remarkable progress in understanding changes that accompany certain forms
Lynch, M. A., Ma, Lynch
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