Results 1 to 10 of about 80,675 (256)

Discovery of a β-arrestin-biased CCKBR agonist that blocks CCKBR-dependent long-term potentiation [PDF]

Nature Communications
The CCKBR agonists induce neocortical long-term potentiation of excitatory synaptic transmission and enhance memory formation, while its antagonists weaken the potentiation in the amygdala and alleviate depression-like behaviors.
Heng Shi, Mengfan Zhang, Xiaofeng Hu, Jie Zhang, Tao Chen, Pingzhou Wu, Xue Wang, Shu Wei, George Choy, Stephen Temitayo Bello, Huifeng Chen, Chunhua Liu, Yiping Guo, Hongyan Sun, Jufang He   +14 more
doaj   +2 more sources

The Pathway-Selective Dependence of Nitric Oxide for Long-Term Potentiation in the Anterior Cingulate Cortex of Adult Mice [PDF]

Biomedicines
Nitric oxide (NO) is a key diffusible messenger in the mammalian brain. It has been proposed that NO may diffuse in retrograde into presynaptic terminals, contributing to the induction of hippocampal long-term potentiation (LTP).
Qi-Yu Chen, Jinjin Wan, Yujie Ma, Min Zhuo   +3 more
doaj   +2 more sources

Involvement of CX3CL1/CX3CR1 signaling in spinal long term potentiation. [PDF]

PLoS ONE, 2015
The long-term potentiation (LTP) of spinal C-fiber-evoked field potentials is considered as a fundamental mechanism of central sensitization in the spinal cord.
Chao Bian, Zhi-Qi Zhao, Yu-Qiu Zhang, Ning Lü   +3 more
doaj   +1 more source

Loss of the actin regulator cyclase-associated protein 1 (CAP1) modestly affects dendritic spine remodeling during synaptic plasticity

European Journal of Cell Biology, 2023
Dendritic spines form the postsynaptic compartment of most excitatory synapses in the vertebrate brain. Morphological changes of dendritic spines contribute to major forms of synaptic plasticity such as long-term potentiation (LTP) or depression (LTD ...
Anika Heinze, Marco B. Rust
doaj   +1 more source

Long-term potentiation in isolated dendritic spines. [PDF]

PLoS ONE, 2009
BACKGROUND:In brain, N-methyl-D-aspartate (NMDA) receptor (NMDAR) activation can induce long-lasting changes in synaptic alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptor (AMPAR) levels.
Amadou T Corera, Guy Doucet, Edward A Fon   +2 more
doaj   +1 more source

Presynaptic long-term potentiation requires extracellular signal-regulated kinases in the anterior cingulate cortex

Molecular Pain, 2020
Extracellular signal-regulated kinases are widely expressed protein kinases in neurons, which serve as important intracellular signaling molecules for central plasticity such as long-term potentiation.
Qi-Yu Chen, Zhi-Ling Zhang, Qin Liu, Chao-Jun Chen, Xiao-Kang Zhang, Ping-Yi Xu, Min Zhuo   +6 more
doaj   +1 more source

Core-Shell Dual-Gate Nanowire Charge-Trap Memory for Synaptic Operations for Neuromorphic Applications

Nanomaterials, 2021
This work showcases the physical insights of a core-shell dual-gate (CSDG) nanowire transistor as an artificial synaptic device with short/long-term potentiation and long-term depression (LTD) operation.
Md. Hasan Raza Ansari, Udaya Mohanan Kannan, Seongjae Cho   +2 more
doaj   +1 more source

Nutritional deficit and Long Term Potentiation alterations

Journal of Biological Research, 2009
In the present work we examined the ability of prenatally malnourished offspring to produce and maintain long-term potentiation (LTP) of the perforant path/dentate granule cell synapse in freely moving rats at 15,30, and 90 days of age.
M. Petrosino, G. Pizzuti
doaj   +1 more source

Rapid Recovery From Cortical Blindness Caused by an Old Cerebral Infarction

Frontiers in Neurology, 2020
When the primary visual cortex (V1) is damaged, cortical blindness results. However, visual information obtained from the superior colliculus (SC) or direct thalamic afferents to higher visual cortices produces unconscious visual functions called ...
Katsuei Shibuki, Katsuei Shibuki, Ichiro Wakui, Takeo Fujimura, Masaru Tomikawa, Shin Hasegawa   +5 more
doaj   +1 more source

Purkinje cells translate subjective salience into readiness to act and choice performance

Cell Reports, 2021
Summary: The brain selectively allocates attention from a continuous stream of sensory input. This process is typically attributed to computations in distinct regions of the forebrain and midbrain.
Lorenzo Bina, Vincenzo Romano, Tycho M. Hoogland, Laurens W.J. Bosman, Chris I. De Zeeuw   +4 more
doaj   +1 more source