Emulating long-term synaptic dynamics with memristive devices [PDF]
, 2016 The potential of memristive devices is often seeing in implementing neuromorphic architectures for achieving brain-like computation. However, the designing procedures do not allow for extended manipulation of the material, unlike CMOS technology, the ...
Berdan, Radu +5 more
core +2 more sources
Erythropoietin enhances hippocampal long-term potentiation and memory
BMC Biology, 2008 Background Erythropoietin (EPO) improves cognition of human subjects in the clinical setting by as yet unknown mechanisms. We developed a mouse model of robust cognitive improvement by EPO to obtain the first clues of how EPO influences cognition, and ...
El-Kordi Ahmed +19 more
doaj +1 more source
Long-term potentiation in the hippocampus: discovery, mechanisms and function
Neuroforum, 2018 In this review we reflect upon our contributions to the study of the properties and mechanisms of long-term potentiation (LTP) and describe some of the major influences on our work. We then go on to consider whether LTP has fulfilled its early promise of
T. Bliss +3 more
semanticscholar +1 more source
No requirement of TRPV1 in long-term potentiation or long-term depression in the anterior cingulate cortex [PDF]
, 2014 One major interest in the study of transient receptor potential vanilloid type 1 (TRPV1) in sensory system is that it may serve as a drug target for treating chronic pain.
Min Zhuo, Ming-Gang Liu
core +1 more source
Temporal sensitivity of protein kinase a activation in late-phase long term potentiation. [PDF]
PLoS Computational Biology, 2010 Protein kinases play critical roles in learning and memory and in long term potentiation (LTP), a form of synaptic plasticity. The induction of late-phase LTP (L-LTP) in the CA1 region of the hippocampus requires several kinases, including CaMKII and PKA,
MyungSook Kim +3 more
doaj +1 more source
, 2016 Synaptic memory is considered to be the main element responsible for learning and cognition in humans. Although traditionally non-volatile long-term plasticity changes have been implemented in nanoelectronic synapses for neuromorphic applications, recent
Roy, Kaushik, Sengupta, Abhronil
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Long-term potentiation in bone – a role for glutamate in strain-induced cellular memory? [PDF]
, 2003 Background The adaptive response of bone cells to mechanical strain is a primary determinant of skeletal architecture and bone mass. In vivo mechanical loading induces new bone formation and increases bone mineral density whereas disuse, immobilisation ...
Genever Paul G, Spencer Gary J
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Enhanced hippocampal long-term potentiation and spatial learning in aged 11ß-hydroxysteroid dehydrogenase type 1 knock-out mice [PDF]
, 2007 Glucocorticoids are pivotal in the maintenance of memory and cognitive functions as well as other essential physiological processes including energy metabolism, stress responses, and cell proliferation.
Brownstein, D. +9 more
core +2 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source