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Roles of N-Methyl-D-Aspartate Receptors (NMDARs) in Epilepsy [PDF]
Frontiers in Molecular Neuroscience, 2022 Epilepsy is one of the most common neurological disorders characterized by recurrent seizures. The mechanism of epilepsy remains unclear and previous studies suggest that N-methyl-D-aspartate receptors (NMDARs) play an important role in abnormal ...
Shuang Chen +5 more
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Molecular continuity between axon guidance and synaptic function [PDF]
Molecules and Cells: The precise assembly of neural circuits is a marvel of cellular engineering, requiring the seamless coordination of long-range axon navigation and short-range synapse formation.
Seongjun Kim +3 more
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Protein quality control of N-methyl-D-aspartate receptors
Frontiers in Cellular Neuroscience, 2022 N-methyl-D-aspartate receptors (NMDARs) are glutamate-gated cation channels that mediate excitatory neurotransmission and are critical for synaptic development and plasticity in the mammalian central nervous system (CNS). Functional NMDARs typically form
Taylor M. Benske +2 more
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The Journal of Poultry Science, 2020 L-Pipecolic acid is an intermediate of L-lysine catabolism. Its central injection exerted a hypnotic effect on the brain, which was partially mediated by the activation of γ-aminobutyric acid-A and γ-aminobutyric acid-B receptors. L-Proline has also been
Asako Shigemura +2 more
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Frontiers in Psychiatry, 2023 BackgroundAntibodies against N-methyl-D-aspartate receptors are the most commonly identified cause of autoimmune encephalitis. While predominantly associated with malignancies, cases of anti-N-methyl-D-aspartate receptor autoimmune encephalitis have been
Thomas Hainmueller +4 more
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Philippine Journal of Obstetrics and Gynecology, 2021 A 24-year-old nulligravida who presented with seizures and behavioral changes with prodrome of flu-like symptoms was initially treated as a case of viral encephalitis.
Finella Marie G. Leonido +1 more
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DEPRESSION-LIKE EFFECTS OF LEVETIRACETAM WAS HALTED BY PRETREATMENT WITH N-METHYL-D-ASPARTATE RECEPTOR (NMDAR) BLOCKERS IN MICE [PDF]
Bulletin of Pharmaceutical Sciences. Assiut University, 2023 N-methyl-D-aspartate receptor (NMDAR) stimulation might be responsible for levetiracetam -(Lev) induced depression. The aim of our study is to evaluate the effect of noncompetitive NMDAR blockers, dextromethorphan (Dxt) and dizocilpine (MK801), on Lev ...
Azadeh Mesripour, Tanin Ahmadi
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Amiloride but not memantine reduces neurodegeneration, seizures and myoclonic jerks in rats with cardiac arrest-induced global cerebral hypoxia and reperfusion. [PDF]
PLoS ONE, 2013 It has been reported that both activation of N-methyl-D-aspartate receptors and acid-sensing ion channels during cerebral ischemic insult contributed to brain injury.
Kwok Keung Tai, Daniel D Truong
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Anti-N-methyl-D-aspartate Receptor Encephalitis [PDF]
Cureus, 2019 Anti-N-methyl-D-aspartate receptor (NMDA) encephalitis is an underrecognized encephalitis that may be mistaken for a wide variety of mental illnesses and causes of delirium. This syndrome is predominantly present in young females presenting with acute psychotic episodes, autonomic instability, and neurologic abnormalities.
Tanquary, Gregory +2 more
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Pharmacology of triheteromeric N-Methyl-d-Aspartate Receptors [PDF]
Neuroscience Letters, 2016 The N-Methyl-D-Aspartate Receptors (NMDARs) are heteromeric cation channels involved in learning, memory, and synaptic plasticity, and their dysregulation leads to various neurodegenerative disorders. Recent evidence has shown that apart from the GluN1/GluN2A and GluN1/GluN2B diheteromeric ion channels, the NMDAR also exists as a GluN1/GluN2A/GluN2B ...
John, Cheriyan +3 more
openaire +2 more sources