In developing hippocampal neurons, NR2B-containing N-methyl-d-aspartate receptors (NMDARs) can mediate signaling to neuronal survival and synaptic potentiation, as well as neuronal death [PDF]
, 2009 It has been suggested that NR2B-containing N-methyl-d-aspartate (NMDA) receptors have a selective tendency to promote pro-death signaling and synaptic depression, compared with the survival promoting, synapse potentiating properties of NR2A-containing ...
Hardingham, G.E. +2 more
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C-Terminal truncation of NR2A subunits impairs synaptic but not extrasynaptic localization of NMDA receptors [PDF]
, 2000 NMDA receptors interact via the extended intracellular C-terminal domain of the NR2 subunits with constituents of the postsynaptic density for purposes of retention, clustering, and functional regulation at central excitatory synapses.
Kennedy, Mary B. +5 more
core +1 more source
Development and characterization of functional antibodies targeting NMDA receptors
Nature Communications, 2022 Selective targeting individual subtypes of N-methyl-D-aspartate receptors (NMDARs) is a desirable therapeutic strategy for neurological disorders.
Nami Tajima +7 more
doaj +1 more source
Brain, Behavior, & Immunity - Health, 2023 Background: Anti-NMDA-receptor GluN1 antibodies (NMDAR1-abs) are present in an autoimmune encephalitis with severe neuropsychiatric symptoms. We aimed to estimate the impact of serum NMDAR1-abs on depressive symptoms years after first-ever ischemic ...
Pia S. Sperber +11 more
doaj +1 more source
Hydrocarbon molar water solubility predicts NMDA vs. GABAA receptor modulation. [PDF]
, 2014 BackgroundMany anesthetics modulate 3-transmembrane (such as NMDA) and 4-transmembrane (such as GABAA) receptors. Clinical and experimental anesthetics exhibiting receptor family specificity often have low water solubility. We hypothesized that the molar
Brosnan, Robert J, Pham, Trung L
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Anti-N-methyl-D-aspartate receptor encephalitis [PDF]
Medicine, 2018 Abstract Rationale: Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is an auto-immune and paraneoplastic encephalitis with prominent neuropsychiatric manifestations. The N-methyl-D-aspartate receptor is located in the forebrain and hippocampus and plays a role in learning and memory.
Li, Hua +3 more
openaire +2 more sources
Mechanism of bidirectional thermotaxis in Escherichia coli. [PDF]
, 2017 In bacteria various tactic responses are mediated by the same cellular pathway, but sensing of physical stimuli remains poorly understood. Here, we combine an in-vivo analysis of the pathway activity with a microfluidic taxis assay and mathematical ...
Erickstad, Michael +8 more
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Derivatives of methoxetamine and major methoxetamine metabolites potently block NMDA receptors
Journal of Pharmacological Sciences, 2022 N-Methyl-D-aspartate receptors (NMDARs) in the brain are influenced by psychoactive drugs such as 2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one (ketamine) and its analog 2-(ethylamino)-2-(3-methoxyphenyl)-cyclohexanone (methoxetamine).
Tomohiko Irie +4 more
doaj +1 more source
Intersubunit Interactions at Putative Sites of Ethanol Action in the M3 and M4 Domains of the NMDA Receptor GluN1 and GluN2B Subunits [PDF]
, 2016 Background and Purpose: The N-methyl-D-aspartate (NMDA) receptor is an important target of alcohol action in the brain. Recent studies in this laboratory have demonstrated that alcohol-sensitive positions in the intersubunit interfaces of the M3 and M4 ...
Alexander +54 more
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ENCEPHALITIS ANTI N-METHYL-D-ASPARTATE RECEPTORS
Mandala Of Health, 2023 Background : Anti-N-Methyl-D-Aspartate receptor encephalitis is an autoimmune disease where the incidence is still rare which is characterized by complex neuropsychiatric syndrome. In severe stages, it can cause morbidity and mortality so it requires adequate intensive therapeutic management.
Calcarina Retno Fitriani Wisudarti +1 more
openaire +1 more source