Results 31 to 40 of about 25,057,876 (282)

Research progress of N⁃methyl⁃D⁃aspartate receptor GRIN2A gene variations and epilepsy

Chinese Journal of Contemporary Neurology and Neurosurgery, 2023
In recent years, with the rapid development of gene sequencing technology, a variety of epilepsy pathogenic genes have been discovered, among which GRIN2A gene variations encoding the neurotransmitter N⁃methyl⁃D⁃aspartate receptor (NMDAR) are closely ...
TANG Wei⁃ting, XIAO Bo
doaj   +1 more source

Uses of magnesium sulfate in anesthesiology

Revista Médica del Hospital General de México, 2022
Introduction: Magnesium sulfate heptahydrate (MgSO4 7H2O) is a divalent cation, pharmacologically its mechanism has been as a reversible blocker of the N-methyl-D-aspartate receptor (NMDAR) and therefore has been proposed in the use of anesthesiology ...
Claudia I. Gutiérrez-Román, Orlando Carrillo-Torres, Emmanuel S. Pérez-Meléndez   +2 more
doaj   +1 more source

Enhancement of spinal dorsal horn neuron N-methyl-D-aspartate receptor phosphorylation as the mechanism of remifentanil-induced hyperalgesia: Roles of protein kinase C and calcium/calmodulin-dependent protein kinase II

Molecular Pain, 2017
Background Modulation of N-methyl-D-aspartate receptor subunits NR1 and NR2 through phosphorylation mediates opioid-induced hyperalgesia, and activations of protein kinase C and extracellular signal-regulated kinase 1/2 potentiate while activation of ...
Sisi Li, Jie Zeng, Xiaoxiao Wan, Ying Yao, Yujia Wu, Nan Zhao, Cong Yu, Zhengyuan Xia   +7 more
doaj   +1 more source

The GluN3 subunit regulates ion selectivity within native N-methyl-d-aspartate receptors

IBRO Reports, 2020
Glutamatergic N-methyl-d-aspartate receptors (NMDARs) are heterotetrameric proteins whose subunits are derived from three gene families, GRIN1 (codes for GluN1), GRIN2 (GluN2) and GRIN3 (GluN3).
Stephen Beesley, Thomas Sullenberger, Sanjay S. Kumar   +2 more
doaj   +1 more source

In silico investigation on the probable macromolecular drug targets involved in the anti-schizophrenia activity of Nardostachys jatamansi [PDF]

Brazilian Journal of Pharmaceutical Sciences, 2022
Existing medications i.e. the antipsychotic drugs are known to be effective in treating only the positive symptoms of schizophrenia, while being ineffective on negative and cognitive symptoms of the disease.
Foong Xi Wei, Anand Gaurav, Mayasah Al-Nema   +2 more
doaj   +1 more source

Anti-N-Methyl-d-Aspartate Receptor Encephalitis

Pediatrics & Neonatology, 2011
Anti-N-methyl-d-aspartate (NMDA) receptor encephalitis is a treatment-responsive encephalitis associated with anti-NMDA receptor antibodies, which bind to the NR1/NR2 heteromers of the NMDA receptors. It is a highly characteristic syndrome evolving in five stages: the prodromal phase (viral infection-like symptoms), psychotic phase, unresponsive phase,
Te-Yu Hung, Ning-Hui Foo, Ming-Chi Lai
openaire   +3 more sources

Development and characterization of functional antibodies targeting NMDA receptors

Nature Communications, 2022
Selective targeting individual subtypes of N-methyl-D-aspartate receptors (NMDARs) is a desirable therapeutic strategy for neurological disorders.
Nami Tajima, Noriko Simorowski, Remy A. Yovanno, Michael C. Regan, Kevin Michalski, Ricardo Gómez, Albert Y. Lau, Hiro Furukawa   +7 more
doaj   +1 more source

Depressive symptoms and anti-N-methyl-D-aspartate-receptor GluN1 antibody seropositivity in the PROSpective cohort with incident stroke

Brain, Behavior, & Immunity - Health, 2023
Background: Anti-NMDA-receptor GluN1 antibodies (NMDAR1-abs) are present in an autoimmune encephalitis with severe neuropsychiatric symptoms. We aimed to estimate the impact of serum NMDAR1-abs on depressive symptoms years after first-ever ischemic ...
Pia S. Sperber, Pimrapat Gebert, Leonie H.A. Broersen, Anna Kufner, Shufan Huo, Sophie K. Piper, Bianca Teegen, Peter U. Heuschmann, Harald Prüss, Matthias Endres, Thomas G. Liman, Bob Siegerink   +11 more
doaj   +1 more source

Derivatives of methoxetamine and major methoxetamine metabolites potently block NMDA receptors

Journal of Pharmacological Sciences, 2022
N-Methyl-D-aspartate receptors (NMDARs) in the brain are influenced by psychoactive drugs such as 2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one (ketamine) and its analog 2-(ethylamino)-2-(3-methoxyphenyl)-cyclohexanone (methoxetamine).
Tomohiko Irie, Yuta Yanase, Yosuke Demizu, Makoto Usami, Ruri Kikura-Hanajiri   +4 more
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source