Results 1 to 10 of about 25,139 (242)

Opioid Tolerance and Physical Dependence: Role of Spinal Neuropeptides, Excitatory Amino Acids and Their Messengers

Pain Research and Management, 2000
Chronic opioid treatment results in the development of tolerance and physical dependence. The mechanisms underlying opioid tolerance and/or physical dependence are unclear.
Khem Jhamandas, Kelly Powell, Remi Quirion, B Milne   +3 more
doaj   +1 more source

Blockade of Glutamate Receptors within the Prelimbic Cortex Attenuate Concentration of Excitatory Amino Acids in the Morphine Self-administration in Rats

Advanced Biomedical Research, 2018
Background: The attitude of research on addiction has been done on the key role of glutamate. As a regard, the prelimbic cortex (PrL) has an important role in addiction, learning, and memory.
Fateme Aboutalebi, Hojjatallah Alaei, Shahrbanoo Oryan   +2 more
doaj   +1 more source

AMPA GluA1-flip targeted oligonucleotide therapy reduces neonatal seizures and hyperexcitability.

PLoS ONE, 2017
Glutamate-activated α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPA-Rs) mediate the majority of excitatory neurotransmission in brain and thus are major drug targets for diseases associated with hyperexcitability or neurotoxicity ...
Nicole M Lykens, David J Coughlin, Jyoti M Reddi, Gordon J Lutz, Melanie K Tallent   +4 more
doaj   +1 more source

Progressive Parkinsonism by acute dysfunction of excitatory amino acid transporters in the rat substantia nigra

Neurobiology of Disease, 2014
Parkinson's disease (PD) is characterized by the progressive degeneration of substantia nigra (SN) dopamine neurons, involving a multifactorial cascade of pathogenic events.
Maxime Assous, Laurence Had-Aissouni, Paolo Gubellini, Christophe Melon, Imane Nafia, Pascal Salin, Lydia Kerkerian-Le-Goff, Philippe Kachidian   +7 more
doaj   +1 more source

Enhanced expression of WD repeat-containing protein 35 (WDR35) stimulated by domoic acid in rat hippocampus: involvement of reactive oxygen species generation and p38 mitogen-activated protein kinase activation

BMC Neuroscience, 2013
Background Domoic acid (DA) is an excitatory amino acid analogue of kainic acid (KA) that acts via activation of glutamate receptors to elicit a rapid and potent excitotoxic response, resulting in neuronal cell death.
Tsunekawa Koji, Kondo Fumio, Okada Teruhiko, Feng Guo-Gang, Huang Lei, Ishikawa Naohisa, Okada Shoshiro   +6 more
doaj   +1 more source

Glutamatergic transmission in the nucleus tractus solitarii: from server to peripherals in the cardiovascular information superhighway

Brazilian Journal of Medical and Biological Research, 1997
Afferent nerves carrying signals from mechanoreceptors in the aortic arch and carotid sinus terminate predominantly in the nucleus tractus solitarii (NTS).
W.T. Talman
doaj   +1 more source

Intrinsic Optical Signals and Electrographic Seizures in the Rat Limbic System

Neurobiology of Disease, 2001
We measured the intrinsic optical signals (IOSs) generated by rat hippocampus-entorhinal cortex (EC) slices in response to single shock electrical stimuli delivered in the EC deep layers during application of the convulsant drug 4-aminopyridine (50 μM ...
Giovanna D'Arcangelo, Virginia Tancredi, Massimo Avoli   +2 more
doaj   +1 more source

Enhanced pre-synaptic glutamate release in deep-dorsal horn contributes to calcium channel alpha-2-delta-1 protein-mediated spinal sensitization and behavioral hypersensitivity

Molecular Pain, 2009
Nerve injury-induced expression of the spinal calcium channel alpha-2-delta-1 subunit (Cavα2δ1) has been shown to mediate behavioral hypersensitivity through a yet identified mechanism.
Dickenson Anthony H, Feng Guoping, Kim Doo-Sik, Matthews Elizabeth A, Deng Ping, Nguyen David, Xu Zao C, Luo Z David   +7 more
doaj   +1 more source

Conversion of silent synapses to AMPA receptor-mediated functional synapses in human cortical organoids

Neuroscience Research
Despite the crucial role of synaptic connections and neural activity in the development and organization of cortical circuits, the mechanisms underlying the formation of functional synaptic connections in the developing human cerebral cortex remain ...
Masatoshi Nishimura, Tomoki Kodera, Shota Adachi, Akinori Y. Sato, Ryosuke F. Takeuchi, Hiroshi Nonaka, Itaru Hamachi, Fumitaka Osakada   +7 more
doaj   +1 more source

DEVELOPMENT OF COMPLEX PHARMACOTHERAPY OF SEVERE AND MODERATE PAIN. PART I. MULTITARGETED COMBINATION OF OPIOIDS AND NON-OPIOID ANALGESICS WITH CENTRAL EFFECTS

Разработка и регистрация лекарственных средств, 2019
Medicines based on opioid analgesics are the basic means of pharmacotherapy of severe pain at present. Approaches to increase efficacy and safety of complex opioid analgesia are described and classified based on analysis of medicinal and veterinary ...
A. V. Sosnov, F. M. Semchenko, M. I. Vlasov, V. N. Tohmahchi, A. A. Sosnova   +4 more
doaj