Results 21 to 30 of about 25,139 (242)

α-Lipoic Acid Derivatives as Allosteric Modulators for Targeting AMPA-Type Glutamate Receptors’ Gating Modules

Cells, 2022
The ionotropic glutamate receptor subtype α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) is responsible for most excitatory transmission in the brain.
Mohammad Qneibi, Safa’ Nassar, Sosana Bdir, Adel Hidmi   +3 more
doaj   +1 more source

Effect of excitatory and inhibitory agents and a glial inhibitor on optically-recorded primary-afferent excitation

Molecular Pain, 2008
The effects of GABA, excitatory amino-acid receptors antagonists and a glial metabolism inhibitor on primary-afferent excitation in the spinal dorsal horn were studied by imaging the presynaptic excitation of high-threshold afferents in cord slices from ...
Murase Kazuyuki, Kiritoshi Takaki, Ikeda Hiroshi   +2 more
doaj   +1 more source

Abolishing spontaneous epileptiform activity in human brain tissue through AMPA receptor inhibition

Annals of Clinical and Translational Neurology, 2020
Objective The amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid receptor (AMPAR) is increasingly recognized as a therapeutic target in drug‐refractory pediatric epilepsy.
Sukhvir K. Wright, Max A. Wilson, Richard Walsh, William B. Lo, Nilesh Mundil, Shakti Agrawal, Sunny Philip, Stefano Seri, Stuart D. Greenhill, Gavin L. Woodhall   +9 more
doaj   +1 more source

G-protein coupled estrogen receptor (GPER1) activation promotes synaptic insertion of AMPA receptors and induction of chemical LTP at hippocampal temporoammonic-CA1 synapses

Molecular Brain, 2023
It is well documented that 17β estradiol (E2) regulates excitatory synaptic transmission at hippocampal Shaffer-collateral (SC)-CA1 synapses, via activation of the classical estrogen receptors (ERα and ERβ).
Leigh Clements, Amy Alexander, Kirsty Hamilton, Andrew Irving, Jenni Harvey   +4 more
doaj   +1 more source

Salsolinol facilitates glutamatergic transmission to dopamine neurons in the posterior ventral tegmental area of rats. [PDF]

PLoS ONE, 2012
Although in vivo evidence indicates that salsolinol, the condensation product of acetaldehyde and dopamine, has properties that may contribute to alcohol abuse, the underlying mechanisms have not been fully elucidated.
Guiqin Xie, Jiang-Hong Ye
doaj   +1 more source

Modulation of glutamate transport and receptor binding by glutamate receptor antagonists in EAE rat brain. [PDF]

PLoS ONE, 2014
The etiology of multiple sclerosis (MS) is currently unknown. However, one potential mechanism involved in the disease may be excitotoxicity. The elevation of glutamate in cerebrospinal fluid, as well as changes in the expression of glutamate receptors ...
Grzegorz Sulkowski, Beata Dąbrowska-Bouta, Elżbieta Salińska, Lidia Strużyńska   +3 more
doaj   +1 more source

Platelet-derived growth factor-BB pretreatment attenuates excitotoxic death in cultured hippocampal neurons

Neurobiology of Disease, 2005
Neuronal excitotoxic death results from excess stimulation by elevated levels of extracellular glutamate acting on N-methyl-d-aspartate (NMDA) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors.
Henry C. Tseng, Marc A. Dichter
doaj   +1 more source

An Insight into Animal Glutamate Receptors Homolog of Arabidopsis thaliana and Their Potential Applications—A Review

Plants, 2022
Most excitatory impulses received by neurons are mediated by ionotropic glutamate receptors (iGluRs). These receptors are located at the apex and play an important role in memory, neuronal development, and synaptic plasticity.
Ruphi Naz, Andleeb Khan, Badrah S. Alghamdi, Ghulam Md Ashraf, Maimonah Alghanmi, Altaf Ahmad, Sheikh Shanawaz Bashir, Qazi Mohd Rizwanul Haq   +7 more
doaj   +1 more source

Unique Features of Network Bursts Emerge From the Complex Interplay of Excitatory and Inhibitory Receptors in Rat Neocortical Networks

Frontiers in Cellular Neuroscience, 2019
Spontaneous network activity plays a fundamental role in the formation of functional networks during early development. The landmark of this activity is the recurrent emergence of intensive time-limited network bursts (NBs) rapidly spreading across the ...
Heidi Teppola, Jugoslava Aćimović, Marja-Leena Linne   +2 more
doaj   +1 more source

Amino acids in the vitreous and intravitreal fluid in rhegmatogenous retinal detachment patients with different proliferative vitreoretinopathy grades

Journal of Ophthalmology, 2015
Background:Proliferative vitreoretinopathy (PVR) is known to worsen the treatment prognosis of rhegmatogenous retinal detachment (RRD) and to result in irreversible loss of vision due to apoptotic or necrotic process in retinal neurons. Some studies have
G.V. Levitskaya
doaj   +1 more source