Results 11 to 20 of about 44,108 (332)

Excitatory amino acid antagonists induce a phencyclidine-like catalepsy in pigeons: Structure-activity studies☆

Neuropharmacology, 1987
Wouter Koek, Jeremy Woods, Mark P. Mattson, Allan Jacobson, Pamela Mudar   +4 more
openalex   +4 more sources

The Roles of Glutamate Receptors and Their Antagonists in Status Epilepticus, Refractory Status Epilepticus, and Super-Refractory Status Epilepticus

Biomedicines, 2023
Status epilepticus (SE) is a neurological emergency with a high mortality rate. When compared to chronic epilepsy, it is distinguished by the durability of seizures and frequent resistance to benzodiazepine (BZD).
Tzu-Hsin Huang, Ming-Chi Lai, Yu-Shiue Chen, Chin-Wei Huang   +3 more
doaj   +1 more source

A reinforcing circuit action of extrasynaptic GABAA receptor modulators on cerebellar granule cell inhibition. [PDF]

, 2013
GABAA receptors (GABARs) are the targets of a wide variety of modulatory drugs which enhance chloride flux through GABAR ion channels. Certain GABAR modulators appear to acutely enhance the function of δ subunit-containing GABAR subtypes responsible for ...
Karakossian, Movses H, Meera, Pratap, Otis, Thomas S, Santhakumar, Vijayalakshmi   +3 more
core   +9 more sources

Hypothalamic excitatory amino acid receptors mediate stress-induced tachycardia in rats [PDF]

, 1992
The role of hypothalamic excitatory amino acid (EAA) receptors in mediating the cardiovascular response to stress was examined using conscious chronically instrumented rats.
DiMicco, Joseph A., Soltis, Robert P.
core   +2 more sources

α-Lipoic Acid Derivatives as Allosteric Modulators for Targeting AMPA-Type Glutamate Receptors’ Gating Modules

Cells, 2022
The ionotropic glutamate receptor subtype α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) is responsible for most excitatory transmission in the brain.
Mohammad Qneibi, Safa’ Nassar, Sosana Bdir, Adel Hidmi   +3 more
doaj   +1 more source

Interaction of hypothalamic GABA\u3csub\u3eA\u3c/sub\u3e and excitatory amino acid receptors controlling heart rate in rats [PDF]

, 1991
We have previously shown that microinjection of drugs that impair gamma-aminobutyric acid (GABA)-mediated synaptic inhibition into the dorsomedial hypothalamus (DMH) of rats generates cardiovascular and behavioral changes that mimic the response to ...
DiMicco, Joseph A., Soltis, Robert P.
core   +2 more sources

Effect of excitatory and inhibitory agents and a glial inhibitor on optically-recorded primary-afferent excitation

Molecular Pain, 2008
The effects of GABA, excitatory amino-acid receptors antagonists and a glial metabolism inhibitor on primary-afferent excitation in the spinal dorsal horn were studied by imaging the presynaptic excitation of high-threshold afferents in cord slices from ...
Murase Kazuyuki, Kiritoshi Takaki, Ikeda Hiroshi   +2 more
doaj   +1 more source

Abolishing spontaneous epileptiform activity in human brain tissue through AMPA receptor inhibition

Annals of Clinical and Translational Neurology, 2020
Objective The amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid receptor (AMPAR) is increasingly recognized as a therapeutic target in drug‐refractory pediatric epilepsy.
Sukhvir K. Wright, Max A. Wilson, Richard Walsh, William B. Lo, Nilesh Mundil, Shakti Agrawal, Sunny Philip, Stefano Seri, Stuart D. Greenhill, Gavin L. Woodhall   +9 more
doaj   +1 more source

Salsolinol facilitates glutamatergic transmission to dopamine neurons in the posterior ventral tegmental area of rats. [PDF]

PLoS ONE, 2012
Although in vivo evidence indicates that salsolinol, the condensation product of acetaldehyde and dopamine, has properties that may contribute to alcohol abuse, the underlying mechanisms have not been fully elucidated.
Guiqin Xie, Jiang-Hong Ye
doaj   +1 more source

GABA\u3csub\u3eA\u3c/sub\u3e and excitatory amino acid receptors in dorsomedial hypothalamus and heart rate in rats [PDF]

, 1991
We have previously shown that microinjection of drugs that interfere with the function of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) into the hypothalamus produces cardiorespiratory and behavioral changes resembling those seen in ...
DiMicco, Joseph A., Soltis, Robert P.
core   +2 more sources