Results 1 to 10 of about 8,623,839 (302)

Metabolism of Amino Acids in Cancer

Frontiers in Cell and Developmental Biology, 2021
Metabolic reprogramming has been widely recognized as a hallmark of malignancy. The uptake and metabolism of amino acids are aberrantly upregulated in many cancers that display addiction to particular amino acids.
Zhen Wei, Xiaoyi Liu, Chunming Cheng, Wei Yu, P. Yi   +4 more
semanticscholar   +1 more source

Amino acids in cancer

Experimental and Molecular Medicine, 2020
Over 90 years ago, Otto Warburg’s seminal discovery of aerobic glycolysis established metabolic reprogramming as one of the first distinguishing characteristics of cancer1.
Elizabeth L. Lieu, Tu-Lan Nguyen, Shawn Rhyne, Jiyeon Kim   +3 more
semanticscholar   +1 more source

Amino Assets: How Amino Acids Support Immunity.

Cell Metabolism, 2020
Amino acids are fundamental building blocks supporting life. Their role in protein synthesis is well defined, but they contribute to a host of other intracellular metabolic pathways, including ATP generation, nucleotide synthesis, and redox balance, to ...
B. Kelly, Erika L. Pearce
semanticscholar   +1 more source

Influence of Leucine on Protein Metabolism of Chicken Embryo Myoblasts is Modulated by Varying Serum Concentrations in the Medium

The Journal of Poultry Science, 2007
The influence of varying leucine and fetal calf serum (FCS) concentrations in the culture medium on protein synthesis and degradation of chicken embryo myoblasts was examined.
Mai Oki, Hiroyuki Sato, Kazuki Nakagawa, Kazumi Kita   +3 more
doaj   +1 more source

Stable Isotope Labeling by Amino Acids in Cell Culture, SILAC, as a Simple and Accurate Approach to Expression Proteomics*

Molecular & Cellular Proteomics, 2002
Quantitative proteomics has traditionally been performed by two-dimensional gel electrophoresis, but recently, mass spectrometric methods based on stable isotope quantitation have shown great promise for the simultaneous and automated identification and ...
Shao-En Ong, Blagoy Blagoev, I. Kratchmarova, D. B. Kristensen, H. Steen, A. Pandey, M. Mann   +6 more
semanticscholar   +1 more source

Fluorescent Reporters and Biosensors for Probing the Dynamic Behavior of Protein Kinases

Proteomes, 2015
Probing the dynamic activities of protein kinases in real-time in living cells constitutes a major challenge that requires specific and sensitive tools tailored to meet the particular demands associated with cellular imaging.
Juan A. González-Vera, May C. Morris
doaj   +1 more source

Variants of the industrially relevant protease KP-43 with suppressed activity under alkaline conditions developed using expanded genetic codes

Biochemistry and Biophysics Reports, 2019
In the present study, we attempted to control the pH profile of the catalytic activity of the industrially relevant alkaline protease KP-43, by incorporating 3-nitro-l-tyrosine and 3-chloro-l-tyrosine at and near the catalytic site. Thirty KP-43 variants
Tatsuya Osamura, Mitsuyoshi Okuda, Atsushi Yamaguchi, Kazumasa Ohtake, Kensaku Sakamoto, Yasushi Takimura   +5 more
doaj   +1 more source

Xenogeneic, extracorporeal liver perfusion in primates improves the ratio of branched-chain amino acids to aromatic amino acids (Fischer's ratio) [PDF]

, 1999
In fulminant hepatic failure (FHF), the development of hepatic encephalopathy is associated with grossly abnormal concentrations of plasma amino acids (PAA).
Hammer, C., Heil, W., Lemmens, H.-P., Matthes, M., Neuhaus, P., Padval, D., Puhl, G., Schön, M. R.   +7 more
core   +1 more source

Recent advances in the synthesis and application of fluorescent α-amino acids [PDF]

, 2016
Fluorescence spectroscopy has become a powerful technique for probing a range of complex biological processes including enzyme mechanisms and protein-protein interactions. While the application of this technique uses a number of strategies, many of these
Harkiss, Alexander, Sutherland, Andrew
core   +1 more source

Excitatory Amino Acids.

ChemInform, 1998
AbstractFor Abstract see ChemInform Abstract in Full Text.
Mark G. Moloney, Mark G. Moloney, Mark G. Moloney   +2 more
openaire   +5 more sources