Results 1 to 10 of about 1,482,447 (317)

LLM4THP: a computing tool to identify tumor homing peptides by molecular and sequence representation of large language model based on two-layer ensemble model strategy

Amino Acids
Tumor homing peptides (THPs) have a distinctive capacity to specifically attach to tumor cells, providing a promising approach for targeted cancer treatment and detection.
Sen Yang, Piao Xu
doaj   +1 more source

Combined assessment of lysine and N-acetyl cadaverine levels assist as a potential biomarker of the smoker periodontitis

Amino Acids
Periodontitis is an inflammatory condition of supporting structures of teeth leading to attachment and bone loss. Cigarette smoking is the single most important and modifiable risk factor with 5 to 20-fold susceptibility for periodontal diseases. Reverse
Md Haroon Rashid, Sandhya Pavan Kumar Yellarthi, Pavan Kumar Yellarthi, Brinda Goda Lakshmi Didugu, Anitha Mamillapalli   +4 more
doaj   +1 more source

Lateralization of the 5-HT1A receptors in the basolateral amygdala in metabolic and anxiety responses to chronic restraint stress

Amino Acids
Behavioral and functional studies describe hemispheric asymmetry in anxiety and metabolic behaviors in responses to stress. However, no study has reported serotonergic receptor (the 5-HT1A receptor) lateralization in the basolateral amygdala (BLA) in ...
Habib Valipour, Gholam Hossein Meftahi, Gila Pirzad Jahromi, Alireza Mohammadi   +3 more
doaj   +1 more source

Kinetic analysis of D-Alanine upon oral intake in humans

Amino Acids
D-Alanine, a rare enantiomer of alanine, can potentially alleviate the worsening of viral infections and maintain circadian rhythm. This study aimed to analyze the kinetics of D-Alanine upon oral intake.
Tomonori Kimura, Shinsuke Sakai, Masaru Horio, Shiro Takahara, Shoto Ishigo, Maiko Nakane, Eiichi Negishi, Hiroshi Imoto, Masashi Mita, Kenji Hamase, Yoko Higa-Maekawa, Yoichi Kakuta, Masayuki Mizui, Yoshitaka Isaka   +13 more
doaj   +1 more source

PEGylation renders carnosine resistant to hydrolysis by serum carnosinase and increases renal carnosine levels

Amino Acids
Carnosine’s protective effect in rodent models of glycoxidative stress have provided a rational for translation of these findings in therapeutic concepts in patient with diabetic kidney disease.
Shiqi Zhang, Guang Yang, Qinqin Zhang, Yuying Fan, Mingna Tang, Liuhai Shen, Dongchun Zhu, Guiyang Zhang, Benito Yard   +8 more
doaj   +1 more source

Differentiated metabolomic profiling reveals plasma amino acid signatures for primary glomerular disease

Amino Acids
Primary glomerular disease (PGD) is an idiopathic cause of renal glomerular lesions that is characterized by proteinuria or hematuria and is the leading cause of chronic kidney disease (CKD). The identification of circulating biomarkers for the diagnosis
Jiao Wang, Chunyu Zhou, Liqian Lu, Shoujun Wang, Qing Zhang, Zhangsuo Liu   +5 more
doaj   +1 more source

Branched-chain amino acids: physico-chemical properties, industrial synthesis and role in signaling, metabolism and energy production

Amino Acids
Branched-chain amino acids (BCAAs)—leucine (Leu), isoleucine (Ile), and valine (Val)—are essential nutrients with significant roles in protein synthesis, metabolic regulation, and energy production.
Philipp Reifenberg, Aline Zimmer
doaj   +1 more source

Structural insights into the potential binding sites of Cathepsin D using molecular modelling techniques

Amino Acids
Alzheimer’s disease (AD) is the most prevalent type of dementia caused by the accumulation of amyloid beta (Aβ) peptides. The extracellular deposition of Aβ peptides in human AD brain causes neuronal death.
Subodh A. Kamble, Sagar S. Barale, Ali Abdulmawjood Mohammed, Sneha B. Paymal, Nitin M. Naik, Kailas D. Sonawane   +5 more
doaj   +1 more source

HECTD2 as a target for veratric acid in the regulation of ferroptosis in renal cell carcinoma

Amino Acids
Function of HECTD2 in renal cell carcinoma malignant progression is undefined. Molecular mechanism behind anti-cancer effects of veratric acid (VA) from traditional Chinese medicine (TCM) is underexplored.
Dong Lv, Ying Xiang, Tao Song, Jinze Li, Yongbo Chen, Youlong Huili, Taimin Shen   +6 more
doaj   +1 more source

Obituary: in memory of the scientific career of Professor Roger C Harris

Amino Acids
Wim Derave, Paul Greenhaff, Pat Harris, Jay Hoffman, Kent Sahlin, Craig Sale, Bryan Saunders, David Snow   +7 more
doaj   +1 more source