Results 31 to 40 of about 8,623,839 (302)

Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor. [PDF]

, 2016
Cellular amino acid uptake is critical for mTOR complex 1 (mTORC1) activation and cell proliferation. However, the regulation of amino acid uptake is not well-understood.
Braas, Daniel, Christofk, Heather R, Graeber, Thomas G, Krall, Abigail S, Xu, Shili   +4 more
core   +1 more source

Rational designing and synthesizing an antimicrobial peptide from bovine milk casein and evaluating its biological properties

Amino Acids
The overuse of antibiotics has led to a growing crisis—antimicrobial resistance, making it harder to treat infections and pushing scientists to find new solutions.
Seyed Reza Pourhosseini, Bahman Akbari, Elahe Ghods, Kamal Veisi, Hamid Madanchi   +4 more
doaj   +1 more source

Transport of the uremic toxin symmetric dimethylarginine (SDMA) by renal transport proteins

Amino Acids
The L-arginine derivative and uremic toxin symmetric dimethylarginine (SDMA) is an independent risk marker for total mortality and cardiovascular events.
Lorenz A. Scherpinski, Martin F. Fromm, Renke Maas, Jörg König   +3 more
doaj   +1 more source

The Regulatory Role of MeAIB in Protein Metabolism and the mTOR Signaling Pathway in Porcine Enterocytes. [PDF]

, 2018
Amino acid transporters play an important role in cell growth and metabolism. MeAIB, a transporter-selective substrate, often represses the adaptive regulation of sodium-coupled neutral amino acid transporter 2 (SNAT2), which may act as a receptor and ...
Ji, Peng, Li, Guangran, Li, Jianjun, Tan, Bie, Tang, Yulong, Yin, Yulong   +5 more
core   +2 more sources

Essential amino acid supplementation for pressure ulcers: pathophysiological rationale and results from a pilot study

Amino Acids
Pressure ulcers (PU) are a major and serious problem affecting millions of people. Malnutrition, frequently co-occurring with PU, is considered modifiable risk factor, and dietary supplements currently recommended for supporting PU healing contain a high
Maciej Świątkiewicz, Andrzej Lejczak, Piotr Foltyński, Paweł Grieb   +3 more
doaj   +1 more source

Enhanced γ-aminobutyric acid levels promote degeneration of silk glands following spermidine supplementation in Bombyx mori

Amino Acids
Silk glands are modified labial glands that produce silk which has immense commercial importance. Silk is extruded out in liquid form after which the glands undergo autophagy and apoptosis during larval to pupal transition.
Brinda Goda Lakshmi Didugu, Anitha Mamillapalli   +1 more
doaj   +1 more source

Candidate amino acids involved in H+ gating of acid-sensing ion channel 1a [PDF]

, 2008
Acid-sensing ion channels are ligand-gated cation channels, gated by extracellular H+. H+ is the simplest ligand possible, and whereas for larger ligands that gate ion channels complex binding sites in the three-dimensional structure of the proteins have
Chen, Xuanmao, Grunder, Stefan, Paukert, Martin, Polleichtner, Georg, Schindelin, Hermann   +4 more
core   +1 more source

Post-translational modifications of ezrin: a crucial regulator for diseases

Amino Acids
Ezrin is a crucial structural protein that connects the plasma membrane to the actin cytoskeleton to maintain cell shape, adhesion, and motility. Post-translational modifications (PTMs) play a key role in the regulation of various biological functions ...
Yi-Chen Li, Hong-Kai Yuan, Lei-Miao Yin
doaj   +1 more source

Amino Acids and Inherited Amino Acid-Related Disorders [PDF]

Journal of Nutrition and Metabolism, 2018
Amino acids perform multiple essential physiological roles in humans, and accordingly, their importance to health has been the subject of extensive attention. In this special issue of the Journal of Nutrition and Metabolism, we focus on the various inborn errors of amino acid metabolism, their diagnostic challenges, new treatment approaches, and recent
Ina Knerr, Laurie Bernstein, Ellen Crushell, Siobhan O’Sullivan, Jörn Oliver Sass   +4 more
openaire   +3 more sources

An engineered Tetrahymena tRNA(Gln) for in vivo incorporation of unnatural amino acids into proteins by nonsense suppression [PDF]

, 1996
A new tRNA, THG73, has been designed and evaluated as a vehicle for incorporating unnatural amino acids site-specifically into proteins expressed in vivo using the stop codon suppression technique.
Abelson, John N., Dougherty, Dennis A., Du, Fangyong, Kearney, Patrick C., Lester, Henry A., Nowak, Mark W., Saks, Margaret E., Sampson, Jeffrey R.   +7 more
core   +1 more source