Results 41 to 50 of about 1,482,447 (317)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Is It Time to Reconsider the U.S. Recommendations for Dietary Protein and Amino Acid Intake?

, 2023
Since the U.S. Institute of Medicine’s recommendations on protein and amino acid intake in 2005, new information supports the need to re-evaluate these recommendations.
Mary Weiler, Svyatoslav Dvoretskiy, Steven R. Hertzler   +2 more
core   +1 more source

Rational designing and synthesizing an antimicrobial peptide from bovine milk casein and evaluating its biological properties

Amino Acids
The overuse of antibiotics has led to a growing crisis—antimicrobial resistance, making it harder to treat infections and pushing scientists to find new solutions.
Seyed Reza Pourhosseini, Bahman Akbari, Elahe Ghods, Kamal Veisi, Hamid Madanchi   +4 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Transport of the uremic toxin symmetric dimethylarginine (SDMA) by renal transport proteins

Amino Acids
The L-arginine derivative and uremic toxin symmetric dimethylarginine (SDMA) is an independent risk marker for total mortality and cardiovascular events.
Lorenz A. Scherpinski, Martin F. Fromm, Renke Maas, Jörg König   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Postprandial Levels of Branch Chained and Aromatic Amino Acids Associate with Fasting Glycaemia [Elektronisk resurs]

, 2016
High fasting plasma concentrations of isoleucine, phenylalanine, and tyrosine have been associated with increased risk of hyperglycaemia and incidence of type 2 diabetes. Whether these associations are diet or metabolism driven is unknown.
Nilsson, Jeanette, Fernandez, Celine,, Ericson, Ulrika,, Magnusson, Martin,, Melander, Olle,, Lund University., Almgren, Peter,, Ottosson, Filip,   +7 more
core   +1 more source

Dietary Intake and Circulating Amino Acid Concentrations in Relation with Bone Metabolism Markers in Children Following Vegetarian and Omnivorous Diets

, 2023
Scientific studies reported that most vegetarians meet the total protein requirements; however, little is known about their amino acid intakes. We aimed to assess dietary intake and serum amino acid levels in relation to bone metabolism markers in ...
Jadwiga Ambroszkiewicz, Joanna Gajewska, Małgorzata Strucińska, Katarzyna Kuśmierska, Grażyna Rowicka, Joanna Mazur, Magdalena Chełchowska, Witold Klemarczyk   +7 more
core   +1 more source

Essential amino acid supplementation for pressure ulcers: pathophysiological rationale and results from a pilot study

Amino Acids
Pressure ulcers (PU) are a major and serious problem affecting millions of people. Malnutrition, frequently co-occurring with PU, is considered modifiable risk factor, and dietary supplements currently recommended for supporting PU healing contain a high
Maciej Świątkiewicz, Andrzej Lejczak, Piotr Foltyński, Paweł Grieb   +3 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source