Results 1 to 10 of about 690,196 (302)

PKA drives an increase in AMPA receptor unitary conductance during LTP in the hippocampus

Nature Communications, 2021
Long-term potentiation at hippocampal CA1 synapses can be due to increasing the number and/or single-channel conductance of AMPA receptors. The authors show that PKA and CaMKII are necessary and together sufficient to increase single channel conductance,
Pojeong Park, John Georgiou, Thomas M. Sanderson, Kwang-Hee Ko, Heather Kang, Ji-il Kim, Clarrisa A. Bradley, Zuner A. Bortolotto, Min Zhuo, Bong-Kiun Kaang, Graham L. Collingridge   +10 more
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Higher Levels of Pro-inflammatory Cytokines Are Associated With Higher Levels of Glutamate in the Anterior Cingulate Cortex in Depressed Adolescents

Frontiers in Psychiatry, 2021
Animal models of stress and related conditions, including depression, have shown that elevated peripheral levels of inflammatory cytokines have downstream consequences on glutamate (Glu) in the brain. Although studies in human adults with depression have
Tiffany C. Ho, Giana I. Teresi, Jillian R. Segarra, Amar Ojha, Johanna C. Walker, Meng Gu, Daniel M. Spielman, Matthew D. Sacchet, Fei Jiang, Yael Rosenberg-Hasson, Holden Maecker, Ian H. Gotlib   +11 more
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Glutamate Scavenging as a Neuroreparative Strategy in Ischemic Stroke

Frontiers in Pharmacology, 2022
Stroke is the second highest reason of death in the world and the leading cause of disability. The ischemic stroke makes up the majority of stroke cases that occur due to the blockage of blood vessels. Therapeutic applications for ischemic stroke include
Oykum Kaplan-Arabaci, Oykum Kaplan-Arabaci, Alperen Acari, Pinar Ciftci, Devrim Gozuacik, Devrim Gozuacik, Devrim Gozuacik   +6 more
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Illuminating Relationships Between the Pre- and Post-synapse

Frontiers in Neural Circuits, 2020
Excitatory synapses in the mammalian cortex are highly diverse, both in terms of their structure and function. However, relationships between synaptic features indicate they are highly coordinated entities.
Thomas M. Sanderson, John Georgiou, Graham L. Collingridge, Graham L. Collingridge, Graham L. Collingridge   +4 more
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Structural basis of subtype-selective competitive antagonism for GluN2C/2D-containing NMDA receptors

Nature Communications, 2020
Selectively inhibiting N-Methyl-D-aspartate receptors (NMDARs) containing the GluN2C/2D subunits has been challenging. Here, using electrophysiology and X-ray crystallography, authors show that compounds UBP791 and UBP1700 show over 40- and 50-fold ...
Jue Xiang Wang, Mark W. Irvine, Erica S. Burnell, Kiran Sapkota, Robert J. Thatcher, Minjun Li, Noriko Simorowski, Arturas Volianskis, Graham L. Collingridge, Daniel T. Monaghan, David E. Jane, Hiro Furukawa   +11 more
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Roles of N-Methyl-D-Aspartate Receptors (NMDARs) in Epilepsy

Frontiers in Molecular Neuroscience, 2022
Epilepsy is one of the most common neurological disorders characterized by recurrent seizures. The mechanism of epilepsy remains unclear and previous studies suggest that N-methyl-D-aspartate receptors (NMDARs) play an important role in abnormal ...
Shuang Chen, Da Xu, Liu Fan, Zhi Fang, Xiufeng Wang, Man Li   +5 more
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(2,6)- and (2,6)-hydroxynorketamine inhibit the induction of NMDA receptor-dependent LTP at hippocampal CA1 synapses in mice

Brain and Neuroscience Advances, 2020
The ketamine metabolite (2 R ,6 R )-hydroxynorketamine has been proposed to have rapid and persistent antidepressant actions in rodents, but its mechanism of action is controversial.
Heather Kang, Pojeong Park, Muchun Han, Patrick Tidball, John Georgiou, Zuner A. Bortolotto, David Lodge, Bong-Kiun Kaang, Graham L. Collingridge   +8 more
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Critical Neurotransmitters in the Neuroimmune Network

Frontiers in Immunology, 2020
Immune cells rely on cell-cell communication to specify and fine-tune their responses. They express an extensive network of cell communication modes, including a vast repertoire of cell surface and transmembrane receptors and ligands, membrane vesicles ...
Thomas Wesley Hodo, Thomas Wesley Hodo, Thomas Wesley Hodo, Maria Teresa Prudente de Aquino, Akiko Shimamoto, Anil Shanker, Anil Shanker, Anil Shanker, Anil Shanker, Anil Shanker   +9 more
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Modulating intrinsic functional connectivity with visual cortex using low‐frequency repetitive transcranial magnetic stimulation

Brain and Behavior, 2022
Introduction Intrinsic network connectivity becomes altered in pathophysiology. Noninvasive brain stimulation can modulate pathological functional networks in an attempt to restore the inherent response.
Sara A. Rafique, Jennifer K. E. Steeves
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Global trends in research of glutamate in epilepsy during past two decades: A bibliometric analysis

Frontiers in Neuroscience, 2022
Epilepsy affects more than 70 million people in the world. It is characterized by recurrent spontaneous seizures, and it is related to many neurological, cognitive, and psychosocial consequences.
Wei Wang, Runshi Gao, Zhiwei Ren, Dongju Yang, Ke Sun, Xiaoling Li, Suying Yan   +6 more
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