Results 41 to 50 of about 502,486 (298)
Biomolecules, 2022 Glutamate is the major excitatory neurotransmitter in the central nervous system and is intricately linked to learning and memory. Its activity depends on the expression of AMPA and NMDA receptors and excitatory amino transporters on neurons and glial ...
Yan Zhang +2 more
doaj +1 more source
Mitochondrial targeting adaptation of the hominoid-specific glutamate dehydrogenase driven by positive Darwinian selection [PDF]
, 2008 Many new gene copies emerged by gene duplication in hominoids, but little is known with respect to their functional evolution. Glutamate dehydrogenase (GLUD) is an enzyme central to the glutamate and energy metabolism of the cell.
Rosso, L. +17 more
core +2 more sources
Biomedicines, 2023 Drug-resistant epilepsy (DRE) is associated with high extracellular levels of glutamate. Studies support the idea that cannabidiol (CBD) decreases glutamate over-release.
Christopher Martínez-Aguirre +11 more
doaj +1 more source
Microglial glutathione and glutamate: regulation mechanisms [PDF]
, 2009 Microglia, the immune cells of the central nervous system (CNS), are important in the protection of the CNS, but may be implicated in the pathogenesis of neuroinflammatory disease.
Fry, V.A.H.
core
Regulation of the Maturation of Osteoblasts and Osteoclastogenesis by Glutamate
, 2009 A B S T R A C T Glutamate, an important central excitatory neurotransmitter, is also secreted by osteoblasts and may be involved in the regulation of bone metabolism.
LIN, TZU-HUNG;YANG, RONG-SEN;TANG, CHIH -HSIN;WU, MING-YUEH;FU, WEN-MEI +1 more
core +1 more source
Kinetic model of the glutamate neuron-astrocytic system. N-acetylaspartylglutamate and glutamate carboxypeptidase [PDF]
, 2023 Kinetic model of excitatory synapse functioning with glutamate and N-acetylaspartylglutamate (NAAG) as neurotransmitters in a three-component system regarding neuroglial astrocytic cells and the glutamate carboxypeptidase (GCPII) enzyme has been ...
Svetlana, Tsybenova +2 more
core +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
A second case of glutaminase hyperactivity: Expanding the phenotype with epilepsy
JIMD Reports, 2023 Glutaminase (GLS) hyperactivity was first described in 2019 in a patient with profound developmental delay and infantile cataract. Here, we describe a 4‐year‐old boy with GLS hyperactivity due to a de novo heterozygous missense variant in GLS, detected ...
Lynne Rumping +9 more
doaj +1 more source
Biosensors, 2023 Glutamate, a non-essential amino acid produced by fermentation, plays a significant role in disease diagnosis and food safety. It is important to enable the real-time monitoring of glutamate concentration for human health and nutrition.
Ting Cai +5 more
doaj +1 more source
Regulation of metabotropic glutamate receptor subtype 7a by PDZ-domain protein PICK1 [PDF]
, 2007 Metabotropic glutamate receptor subtype 7 (mGluR7) belongs to the family of G-protein coupled receptors. mGluR7 is widely distributed in the brain and primarily localized at presynaptic terminals, where it is thought to regulate neurotransmitter release ...
Zhang, C., Zhang, Chuansheng
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