Results 41 to 50 of about 690,196 (302)

Caenorhabditis elegans male sensory-motor neurons and dopaminergic support cells couple ejaculation and post-ejaculatory behaviors

eLife, 2014
The circuit structure and function underlying post-coital male behaviors remain poorly understood. Using mutant analysis, laser ablation, optogenetics, and Ca2+ imaging, we observed that following C.
Brigitte LeBoeuf, Paola Correa, Changhoon Jee, L René García   +3 more
doaj   +1 more source

Purification and Reconstitution of the Glutamate Carrier GltT of the Thermophilic Bacterium Bacillus stearothermophilus [PDF]

, 1995
An affinity tag consisting of six adjacent histidine residues followed by an enterokinase cleavage site was genetically engineered at the N-terminus of the glutamate transport protein GltT of the thermophilic bacterium Bacillus stearothermophilus.
Bassilana M., Deguchi Y., Heyne R. I. R., Hirata H., Hochuli E., Kaback H. R., Knol J., Lolkema J. S., Lolkema J. S., Newman M. J., Pines G., Poolman B., Pos K. M., Rigaud J.-L., Ruan Z.-S., Sambrook J., Tolner B., Tolner B., Tolner B., Zhang Y.   +19 more
core   +2 more sources

Complementary contributions of basolateral amygdala and orbitofrontal cortex to value learning under uncertainty

eLife, 2017
We make choices based on the values of expected outcomes, informed by previous experience in similar settings. When the outcomes of our decisions consistently violate expectations, new learning is needed to maximize rewards.
Alexandra Stolyarova, Alicia Izquierdo
doaj   +1 more source

DL-3-n-butylphthalide enhances synaptic plasticity in mouse model of brain impairments

STEMedicine, 2022
Synaptic impairment results in cognitive dysfunction of Alzheimer’s disease (AD). As a plant extract, it is found that DL-3-n-butylphthalide (L-NBP) rescues abnormal cognitive behaviors in AD animals.
Qian Ding, Qian Yu, Lei Tao, Yifei Guo, Juan Zhao, Jun Yu   +5 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Neuronal activity determines distinct gliotransmitter release from a single astrocyte

eLife, 2018
Accumulating evidence indicates that astrocytes are actively involved in brain function by regulating synaptic activity and plasticity. Different gliotransmitters, such as glutamate, ATP, GABA or D-serine, released form astrocytes have been shown to ...
Ana Covelo, Alfonso Araque
doaj   +1 more source

Synapse-specific diversity of distinct postsynaptic GluN2 subtypes defines transmission strength in spinal lamina I

Frontiers in Synaptic Neuroscience, 2023
The unitary postsynaptic response to presynaptic quantal glutamate release is the fundamental basis of excitatory information transfer between neurons.
Graham M. Pitcher, Graham M. Pitcher, Livia Garzia, A. Sorana Morrissy, Michael D. Taylor, Michael W. Salter, Michael W. Salter   +6 more
doaj   +1 more source

Glutamatergic transmission in the central nucleus of the amygdala is selectively altered in Marchigian Sardinian alcohol-preferring rats: Alcohol and CRF effects [PDF]

, 2015
The CRF system of the central nucleus of the amygdala (CeA) is important for the processing of anxiety, stress, and effects of acute and chronic ethanol.
CICCOCIOPPO, Roberto, Heilig, Markus, Herman, Melissa A, Kirson, Dean, Luu, George, Oleata, Christopher S, Roberto, Marisa, Varodayan, Florence P   +7 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Physiological and Biochemical Markers of the Sex-Specific Sensitivity to Epileptogenic Factors, Delayed Consequences of Seizures and Their Response to Vitamins B1 and B6 in a Rat Model

Pharmaceuticals, 2021
The disturbed metabolism of vitamins B1 or B6, which are essential for neurotransmitters homeostasis, may cause seizures. Our study aims at revealing therapeutic potential of vitamins B1 and B6 by estimating the short- and long-term effects of their ...
Vasily A. Aleshin, Anastasia V. Graf, Artem V. Artiukhov, Alexandra I. Boyko, Alexander L. Ksenofontov, Maria V. Maslova, Isabel Nogués, Martino L. di Salvo, Victoria I. Bunik   +8 more
doaj   +1 more source