Results 41 to 50 of about 662,038 (354)

Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate.

Neuron, 1996
Three glutamate transporters have been identified in rat, including astroglial transporters GLAST and GLT-1 and a neuronal transporter EAAC1. Here we demonstrate that inhibition of the synthesis of each glutamate transporter subtype using chronic ...
J. Rothstein, M. Dykes‐Hoberg, C. Pardo, L. Bristol, Lin Jin, R. Kuncl, Y. Kanai, M. Hediger, Yanfeng Wang, Jerry P Schielke, D. Welty   +10 more
semanticscholar   +1 more source

Similarity and Diversity of Presynaptic Molecules at Neuromuscular Junctions and Central Synapses

Biomolecules, 2022
Synaptic transmission is essential for controlling motor functions and maintaining brain functions such as walking, breathing, cognition, learning, and memory.
Kenji Takikawa, Hiroshi Nishimune
doaj   +1 more source

A thioacetamide-induced hepatic encephalopathy model in C57BL/6 mice: a behavioral and neurochemical study Modelo de encefalopatia hepática induzida por tioacetamida em camundongos C57BL/6: estudo comportamental e neuroquímico

Arquivos de Neuro-Psiquiatria, 2010
OBJECTIVE: Hepatic encephalopathy (HE) is a neuropsychiatric syndrome resulting from liver failure. In the present study, we aimed to standardize an animal model of HE induced by thioacetamide (TAA) in C57BL/6 mice evaluating behavioral symptoms in ...
Aline Silva de Miranda, David Henrique Rodrigues, Luciene Bruno Vieira, Cristiano Xavier Lima, Milene Alvarenga Rachid, Paula Vieira Teixeira Vidigal, Marcus Vinicius Gomez, Helton José dos Reis, Cristina Guatimosim, Antônio Lúcio Teixeira   +9 more
doaj   +1 more source

Cleistocalyx nervosum var. paniala Berry Promotes Antioxidant Response and Suppresses Glutamate-Induced Cell Death via SIRT1/Nrf2 Survival Pathway in Hippocampal HT22 Neuronal Cells

Molecules, 2022
Excessive glutamate neurotransmitters result in oxidative neurotoxicity, similar to neurodegeneration. An indigenous berry of Thailand, Cleistocalyx nervosum var. paniala (CNP), has been recognized for its robust antioxidants. We investigated the effects
Wanchanok Nantacharoen, Seung Joon Baek, Waluga Plaingam, Somsri Charoenkiatkul, Tewin Tencomnao, Monruedee Sukprasansap   +5 more
doaj   +1 more source

The role of astrocytic glutamate transporters GLT-1 and GLAST in neurological disorders: potential targets for neurotherapeutics

Neuropharmacology, 2019
Glutamate is the primary excitatory neurotransmitter in the central nervous system (CNS) that initiates a rapid signal transmission in the synapse before its re-uptake into the surrounding glia, specifically astrocytes.
E. Pajarillo, Asha Rizor, Jayden Lee, M. Aschner, Eun-Jin Leea   +4 more
semanticscholar   +1 more source

Glutamate Receptor [PDF]

, 2016
[No abstract]
openaire   +2 more sources

Glutamate-induced Exocytosis of Glutamate from Astrocytes

Journal of Biological Chemistry, 2007
Recent studies indicate that astrocytes can play a much more active role in neuronal circuits than previously believed, by releasing neurotransmitters such as glutamate and ATP. Here we report that local application of glutamate or glutamine synthetase inhibitors induces astrocytic release of glutamate, which activates a slowly decaying transient ...
Jun, Xu, Hong, Peng, Ning, Kang, Zhuo, Zhao, Jane H-C, Lin, Patric K, Stanton, Jian, Kang   +6 more
openaire   +2 more sources

Mitochondrial targeting adaptation of the hominoid-specific glutamate dehydrogenase driven by positive Darwinian selection [PDF]

, 2008
Many new gene copies emerged by gene duplication in hominoids, but little is known with respect to their functional evolution. Glutamate dehydrogenase (GLUD) is an enzyme central to the glutamate and energy metabolism of the cell.
Rosso, L., Kaessmann, H., Marques, A.C., Reichert, A.S., Ana C. Marques, Lia Rosso, Reichert, Andreas, Kaessmann, Henrik, Kaessmann, H, Marques, AC, Henrik Kaessmann, Marques, Ana C., Andreas S. Reichert, Rosso, Lia, Reichert, AS, Ana C Marques, Andreas S Reichert, Rosso, L   +17 more
core   +2 more sources

Increase of glutamate in satellite glial cells of the trigeminal ganglion in a rat model of craniofacial neuropathic pain

Frontiers in Neuroanatomy, 2023
IntroductionSatellite glial cells (SGCs) that envelop the cell bodies of neurons in sensory ganglia have been shown to both release glutamate, and be activated by glutamate in the context of nociceptive signaling.
Yi Sul Cho, Won Mah, Dong Ho Youn, Yu Shin Kim, Hyoung-Gon Ko, Jin Young Bae, Yun Sook Kim, Yong Chul Bae   +7 more
doaj   +1 more source

GluK2-glutamate [PDF]

, 2015
The subdirectory /MD includes five free MD simulation trajectories of GluK2-glutamate complex, which are used as references in the ...
Marcus Elstner (394014), Wolter, Tino, Trauner, Dirk, Tino Wolter (394013), Guo, Yanan, Martin Sumser (787844), Dirk Trauner (549007), Tomáš Kubař (787843), Elstner, Marcus, Yanan Guo (116950), Kubař, Tomáš, Sumser, Martin   +11 more
core   +1 more source