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Going the Extra (Synaptic) Mile: Excitotoxicity as the Road Toward Neurodegenerative Diseases [PDF]
Frontiers in Cellular Neuroscience, 2020 Excitotoxicity is a phenomenon that describes the toxic actions of excitatory neurotransmitters, primarily glutamate, where the exacerbated or prolonged activation of glutamate receptors starts a cascade of neurotoxicity that ultimately leads to the loss
Adam Armada-Moreira +2 more
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Calcium Permeable-AMPA Receptors and Excitotoxicity in Neurological Disorders
Frontiers in Neural Circuits, 2021 Excitotoxicity is one of the primary mechanisms of cell loss in a variety of diseases of the central and peripheral nervous systems. Other than the previously established signaling pathways of excitotoxicity, which depend on the excessive release of ...
Changyong Guo, Yao-Ying Ma
exaly +6 more sources
Neuroprotective Effects of Daphnetin against NMDA Receptor-Mediated Excitotoxicity
Molecules, 2014 The accumulation of glutamate can excessively activate the N-methyl-d-aspartate (NMDA) receptors and cause excitotoxicity. Daphnetin (Dap), a coumarin derivative, is a protein kinase inhibitor that exhibits antioxidant and neuroprotective properties ...
Le Yang, , Kun Zhang
exaly +4 more sources
Does umbelliferone protect primary cortical neuron cells against glutamate excitotoxicity [PDF]
Kafkas Universitesi Veteriner Fakültesi Dergisi, 2021 Glutamate is the major excitatory neurotransmitter in the central nervous system. Excessive glutamate is known to cause excitotoxicity. Umbelliferone is a coumarin derivative compound and has anti-oxidant, anti-infl ammatory, and neuroprotective eff ects.
Alper Kürşat DEMİRKAYA +5 more
doaj +3 more sources
Molecular mechanisms of NMDA excitotoxicity in the retina
Scientific Reports, 2023 NMDA excitotoxicity, as a part of glutamate excitotoxicity, has been proposed to contribute significantly to many retinal diseases. Therefore, understanding mechanisms of NMDA excitotoxicity will provide further insight into the mechanisms of many ...
Galina Dvoriantchikova +2 more
doaj +2 more sources
Nicorandil mitigates glutamate excitotoxicity in primary cultured neurons
Medicine ScienceExcitotoxicity, caused by the excessive release of glutamate, leads to the activation of the apoptotic process, making it a crucial factor in age-related neurodegenerative diseases.
Muhammed Sait Ertugrul +6 more
doaj +3 more sources
Possible role of excitotoxicity in the pathogenesis of glaucoma
Clinical and Experimental Ophthalmology, 2006 Excitotoxicity describes the process of neuronal injury by excess stimulation of amino acid receptors. This form of insult was first described in the retina, and subsequently has been shown to be an important component of the pathogenesis of ischaemic ...
Robert J Casson
exaly +2 more sources
TRP Channels in Excitotoxicity.
The NeuroscientistGlutamate excitotoxicity is a central mechanism contributing to cellular dysfunction and death in various neurological disorders and diseases, such as stroke, traumatic brain injury, epilepsy, schizophrenia, addiction, mood disorders, Huntington\u27s ...
Feng, Jianlin +3 more
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Dopamine protects neurons against glutamate-induced excitotoxicity [PDF]
, 2013 Glutamate excitotoxicity is responsible for neuronal death in acute neurological disorders including stroke, trauma and neurodegenerative disease. Loss of calcium homeostasis is a key mediator of glutamate-induced cell death.
Gandhi, S +4 more
core +3 more sources
SIRT4 prevents excitotoxicity via modulating glutamate metabolism in glioma cells
Human and Experimental Toxicology, 2020 Excitotoxicity is the presence of excessive glutamate, which is normally taken up by glutamate transporters on astrocytes. Glutamate transporter 1 (GLT-1) is the major transporter on glia cells clearing more than 90% of the glutamate.
Gizem Donmez Yalcin
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