Results 1 to 10 of about 46,858 (164)
Going the Extra (Synaptic) Mile: Excitotoxicity as the Road Toward Neurodegenerative Diseases
Frontiers in Cellular Neuroscience, 2020 Excitotoxicity is a phenomenon that describes the toxic actions of excitatory neurotransmitters, primarily glutamate, where the exacerbated or prolonged activation of glutamate receptors starts a cascade of neurotoxicity that ultimately leads to the loss
Vincenzo Crunelli +2 more
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Calcium Permeable-AMPA Receptors and Excitotoxicity in Neurological Disorders
Frontiers in Neural Circuits, 2021 Excitotoxicity is one of the primary mechanisms of cell loss in a variety of diseases of the central and peripheral nervous systems. Other than the previously established signaling pathways of excitotoxicity, which depend on the excessive release of ...
Yaoying Ma, Changyong Guo
exaly +3 more sources
Neuroprotective Effects of Daphnetin against NMDA Receptor-Mediated Excitotoxicity
Molecules, 2014 The accumulation of glutamate can excessively activate the N-methyl-d-aspartate (NMDA) receptors and cause excitotoxicity. Daphnetin (Dap), a coumarin derivative, is a protein kinase inhibitor that exhibits antioxidant and neuroprotective properties ...
Qi Yang, Kun Zhang, Yujiao Li
exaly +3 more sources
Does umbelliferone protect primary cortical neuron cells against glutamate excitotoxicity [PDF]
Kafkas Universitesi Veteriner Fakültesi Dergisi, 2021 Glutamate is the major excitatory neurotransmitter in the central nervous system. Excessive glutamate is known to cause excitotoxicity. Umbelliferone is a coumarin derivative compound and has anti-oxidant, anti-infl ammatory, and neuroprotective eff ects.
Alper Kürşat DEMİRKAYA +5 more
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The initiator of neuroexcitotoxicity and ferroptosis in ischemic stroke: Glutamate accumulation
Frontiers in Molecular Neuroscience, 2023 Glutamate plays an important role in excitotoxicity and ferroptosis. Excitotoxicity occurs through over-stimulation of glutamate receptors, specifically NMDAR, while in the non-receptor-mediated pathway, high glutamate concentrations reduce cystine ...
Genhao Fan +3 more
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Frontiers in Pharmacology, 2022 Glutamate-induced excitotoxicity is a pathological basis of many acute/chronic neurodegenerative diseases. Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA2b) is a membrane-embedded P-type ATPase pump that manages the translocation of calcium ions (Ca2 ...
Wen Zhang +25 more
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Molecules, 2022 Glutamate excitotoxicity may contribute to retinal ganglion cell (RGC) degeneration in glaucoma and other optic neuropathies, leading to irreversible blindness.
Dongli Zhuang +3 more
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Various facets of excitotoxicity
Exploration of Neuroprotective Therapy, 2022 Aim: Excitotoxicity results from unusually increased activation of excitatory amino acid receptors leading to neuronal death. Since glutamate is the main excitatory neurotransmitter in the central nervous system, it is also the most common ...
Talita Glaser +10 more
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Molecular mechanisms of NMDA excitotoxicity in the retina
Scientific Reports, 2023 NMDA excitotoxicity, as a part of glutamate excitotoxicity, has been proposed to contribute significantly to many retinal diseases. Therefore, understanding mechanisms of NMDA excitotoxicity will provide further insight into the mechanisms of many ...
Galina Dvoriantchikova +2 more
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Insulin Protects Cortical Neurons Against Glutamate Excitotoxicity
Frontiers in Neuroscience, 2019 Glutamate excitotoxicity is implicated in the pathogenesis of numerous diseases, such as stroke, traumatic brain injury, and Alzheimer’s disease, for which insulin resistance is a concomitant condition, and intranasal insulin treatment is believed to be ...
Irina Krasil’nikova +10 more
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