Results 21 to 30 of about 12,017 (197)
Potential protective roles of phytochemicals on glutamate-induced neurotoxicity: A review [PDF]
Iranian Journal of Basic Medical Sciences, 2020 Glutamate, as an essential neurotransmitter, has been thought to have different roles in the central nervous system (CNS), including nerve regeneration, synaptogenesis, and neurogenesis.
Amir R. Afshari +5 more
doaj +1 more source
Molecular mechanisms of ischemia and glutamate excitotoxicity [PDF]
, 2023 Excitotoxicity is classically defined as the neuronal damage caused by the excessive release of glutamate, and subsequent activation of excitatory plasma membrane receptors. In the mammalian brain, this phenomenon is mainly driven by excessive activation
Salazar, Ivan L. +7 more
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Mechanism of Zinc Excitotoxicity: A Focus on AMPK
Frontiers in Neuroscience, 2020 Over the last 20 years, it has been shown that complex signaling cascades are involved in zinc excitotoxicity. Free zinc rapidly induces PKC activation, which causes reactive oxygen species (ROS) production at least in part through NADPH oxidase. It also
Yang-Hee Kim, Jae-Won Eom, Jae-Young Koh
doaj +1 more source
The Susceptibility of Retinal Ganglion Cells to Glutamatergic Excitotoxicity Is Type-Specific
Frontiers in Neuroscience, 2019 Retinal ganglion cells (RGCs) are the only output neurons that conduct visual signals from the eyes to the brain. RGC degeneration occurs in many retinal diseases leading to blindness and increasing evidence suggests that RGCs are susceptible to various ...
Ian Christensen +10 more
doaj +1 more source
Age Associated Sleep Loss: A Trigger For Alzheimer’s Disease
Psychiatry and Clinical Psychopharmacology, 2021 Alzheimer’s disease (AD) is an untreatable, multifactorial, chronic, progressive, neurodegenerative disorder, which is the principal cause of dementia throughout the world and the fourth most important cause of death in developed economies after cancer,
Vivek Kumar Sharma +3 more
doaj +1 more source
, 2007 Endocannabinoids are lipid signaling mediators that exert an important neuromodulatory role and confer neuroprotection in several types of brain injury.
Monory, Krisztina +8 more
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Tau exacerbates excitotoxic brain damage in an animal model of stroke
Nature Communications, 2017 Excitotoxicity contributes to neuronal injury following stroke. Here the authors show that tau promotes excitotoxicity by a post-synaptic mechanism, involving site-specific control of ERK activation, in a mouse model of stroke.
Mian Bi +18 more
doaj +1 more source
Inappropriate Intrusion of an Axonal Mitochondrial Anchor into Dendrites Causes Neurodegeneration
Cell Reports, 2019 Summary: Syntaphilin (SNPH) is a major mitochondrial anchoring protein targeted to axons and excluded from dendrites. In this study, we provide in vivo evidence that this spatial specificity is lost in Shiverer (Shi) mice, a model for progressive ...
Dinesh C. Joshi +8 more
doaj +1 more source
In vivo evidence for NMDA receptor mediated excitotoxicity in a murine genetic model of Huntington Disease [PDF]
, 2008 N-methyl-D-aspartate receptor (NMDAR) mediated excitotoxicity is implicated as a proximate cause of neurodegeneration in Huntington Disease (HD). However, this hypothesis has not been tested rigorously in vivo. NMDAR NR2B-subunits are the predominant NR2
Joe Tsien +4 more
core
Neuroprotective effects of thymosin Î24 in experimental models of excitotoxicity
, 2007 The aim of this study was to evaluate the possible neuroprotective effects of thymosin β4 in different models of excitotoxicity. The application of thymosin β4 significantly attenuated glutamate-induced toxicity both in primary cultures of cortical ...
Mollinari C. +25 more
core +1 more source