Metabolic Changes Following Perinatal Asphyxia: Role of Astrocytes and Their Interaction with Neurons [PDF]
, 2016 Perinatal Asphyxia (PA) represents an important cause of severe neurological deficits including delayed mental and motor development, epilepsy, major cognitive deficits and blindness.
Barreto, George E. +5 more
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Age Associated Sleep Loss: A Trigger For Alzheimer’s Disease
Psychiatry and Clinical Psychopharmacology, 2021 Alzheimer’s disease (AD) is an untreatable, multifactorial, chronic, progressive, neurodegenerative disorder, which is the principal cause of dementia throughout the world and the fourth most important cause of death in developed economies after cancer,
Vivek Kumar Sharma +3 more
doaj +1 more source
Intrinsic up-regulation of 2-AG favors an area specific neuronal survival in different in vitro models of neuronal damage [PDF]
, 2012 BACKGROUND: The endocannabinoid 2-arachidonoyl glycerol (2-AG) acts as a retrograde messenger and modulates synaptic signaling e. g. in the hippocampus. 2-AG also exerts neuroprotective effects under pathological situations.
Bechmann, Ingo Jürgen +8 more
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The Susceptibility of Retinal Ganglion Cells to Glutamatergic Excitotoxicity Is Type-Specific
Frontiers in Neuroscience, 2019 Retinal ganglion cells (RGCs) are the only output neurons that conduct visual signals from the eyes to the brain. RGC degeneration occurs in many retinal diseases leading to blindness and increasing evidence suggests that RGCs are susceptible to various ...
Ian Christensen +10 more
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CXCL12-induced neurotoxicity critically depends on NMDA receptor-gated and L-type Ca2+ channels upstream of p38 MAPK. [PDF]
, 2016 BackgroundThe chemokine receptor CXCR4 (CD184) and its natural ligand CXCL12 contribute to many physiological processes, including decisions about cell death and survival in the central nervous system.
Kaul, Marcus +5 more
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Mechanism of Zinc Excitotoxicity: A Focus on AMPK
Frontiers in Neuroscience, 2020 Over the last 20 years, it has been shown that complex signaling cascades are involved in zinc excitotoxicity. Free zinc rapidly induces PKC activation, which causes reactive oxygen species (ROS) production at least in part through NADPH oxidase. It also
Yang-Hee Kim, Jae-Won Eom, Jae-Young Koh
doaj +1 more source
Transcriptional Profiles for Glutamate Transporters Reveal Differences Between Organophosphates but Similarities with Unrelated Neurotoxicants [PDF]
, 2010 The developmental neurotoxicity of organophosphates involves mechanisms other than their shared property as cholinesterase inhibitors, among which are excitotoxicity and oxidative stress.
Lobner, Doug +2 more
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Tau exacerbates excitotoxic brain damage in an animal model of stroke
Nature Communications, 2017 Excitotoxicity contributes to neuronal injury following stroke. Here the authors show that tau promotes excitotoxicity by a post-synaptic mechanism, involving site-specific control of ERK activation, in a mouse model of stroke.
Mian Bi +18 more
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Inappropriate Intrusion of an Axonal Mitochondrial Anchor into Dendrites Causes Neurodegeneration
Cell Reports, 2019 Summary: Syntaphilin (SNPH) is a major mitochondrial anchoring protein targeted to axons and excluded from dendrites. In this study, we provide in vivo evidence that this spatial specificity is lost in Shiverer (Shi) mice, a model for progressive ...
Dinesh C. Joshi +8 more
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Disruption of nNOS-NOS1AP protein-protein interactions suppresses neuropathic pain in mice [PDF]
, 2018 Elevated N-methyl-D-aspartate receptor (NMDAR) activity is linked to central sensitization and chronic pain. However, NMDAR antagonists display limited therapeutic potential because of their adverse side effects. Novel approaches targeting the NR2B-PSD95-
Chawla, Aarti +6 more
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