Results 21 to 30 of about 57,791 (292)
Molecules, 2022 Glutamate excitotoxicity may contribute to retinal ganglion cell (RGC) degeneration in glaucoma and other optic neuropathies, leading to irreversible blindness.
Dongli Zhuang +3 more
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Various facets of excitotoxicity
Exploration of Neuroprotective Therapy, 2022 Aim: Excitotoxicity results from unusually increased activation of excitatory amino acid receptors leading to neuronal death. Since glutamate is the main excitatory neurotransmitter in the central nervous system, it is also the most common ...
Talita Glaser +10 more
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Insulin Protects Cortical Neurons Against Glutamate Excitotoxicity
Frontiers in Neuroscience, 2019 Glutamate excitotoxicity is implicated in the pathogenesis of numerous diseases, such as stroke, traumatic brain injury, and Alzheimer’s disease, for which insulin resistance is a concomitant condition, and intranasal insulin treatment is believed to be ...
Irina Krasil’nikova +10 more
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Excitotoxicity & Pruning Stalls
How Glutamate Excitotoxicity Hijacks Synaptic Selection Logic. SYSTEM TARGETS: Node 1 (Microglial Pruning Drones), Node 2 (Astrocyte Vacuums), and Synaptic Weighting.
Pavel Banic
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‐mediated excitotoxicity [PDF]
, 2016 Elevated c-Jun levels result in apoptosis and are evident in neurodegenerative disorders such as Alzheimer's disease and dementia and after global cerebral insults including stroke and epilepsy.
Hrdinka, Matous +17 more
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Molecular mechanisms of ischemia and glutamate excitotoxicity [PDF]
, 2023 Excitotoxicity is classically defined as the neuronal damage caused by the excessive release of glutamate, and subsequent activation of excitatory plasma membrane receptors. In the mammalian brain, this phenomenon is mainly driven by excessive activation
Salazar, Ivan L. +7 more
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Is L-Glutamate Toxic to Neurons and Thereby Contributes to Neuronal Loss and Neurodegeneration? A Systematic Review [PDF]
, 2022 L-glutamate (L-Glu) is a nonessential amino acid, but an extensively utilised excitatory neurotransmitter with critical roles in normal brain function. Aberrant accumulation of L-Glu has been linked to neurotoxicity and neurodegeneration.
Al-Nasser, Maryam N. +5 more
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, 2007 Endocannabinoids are lipid signaling mediators that exert an important neuromodulatory role and confer neuroprotection in several types of brain injury.
Monory, Krisztina +8 more
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In vivo evidence for NMDA receptor mediated excitotoxicity in a murine genetic model of Huntington Disease [PDF]
, 2008 N-methyl-D-aspartate receptor (NMDAR) mediated excitotoxicity is implicated as a proximate cause of neurodegeneration in Huntington Disease (HD). However, this hypothesis has not been tested rigorously in vivo. NMDAR NR2B-subunits are the predominant NR2
Joe Tsien +4 more
core
, 2011 Excitotoxicity plays a major role in various neurological disorders. In this study, we explored the behavioral and neurotoxic effects of intraventricular NMDA administration in mice.
CHEN, CHANG-MU;LIN, JEN-KUN;LIU, SHING-HWA;LIN-SHIAU, SHOEI-YN +1 more
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