Results 21 to 30 of about 80,747 (355)
Mfn2 downregulation in excitotoxicity causes mitochondrial dysfunction and delayed neuronal death
EMBO Journal, 2014 Mitochondrial fusion and fission is a dynamic process critical for the maintenance of mitochondrial function and cell viability. During excitotoxicity neuronal mitochondria are fragmented, but the mechanism underlying this process is poorly understood ...
Marc Segarra-Mondejar +2 more
exaly +2 more sources
The initiator of neuroexcitotoxicity and ferroptosis in ischemic stroke: Glutamate accumulation
Frontiers in Molecular Neuroscience, 2023 Glutamate plays an important role in excitotoxicity and ferroptosis. Excitotoxicity occurs through over-stimulation of glutamate receptors, specifically NMDAR, while in the non-receptor-mediated pathway, high glutamate concentrations reduce cystine ...
Genhao Fan +3 more
doaj +1 more source
Excitotoxicity, calcium and mitochondria: a triad in synaptic neurodegeneration
Translational Neurodegeneration, 2022 Glutamate is the most commonly engaged neurotransmitter in the mammalian central nervous system, acting to mediate excitatory neurotransmission. However, high levels of glutamatergic input elicit excitotoxicity, contributing to neuronal cell death ...
M. Verma, Britney N. Lizama, C. Chu
semanticscholar +1 more source
Molecular Neurodegeneration, 2023 Stroke and late-onset Alzheimer’s disease (AD) are risk factors for each other; the comorbidity of these brain disorders in aging individuals represents a significant challenge in basic research and clinical practice.
S. Yu +4 more
semanticscholar +1 more source
Frontiers in Pharmacology, 2022 Glutamate-induced excitotoxicity is a pathological basis of many acute/chronic neurodegenerative diseases. Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA2b) is a membrane-embedded P-type ATPase pump that manages the translocation of calcium ions (Ca2 ...
Wen Zhang +25 more
doaj +1 more source
Molecules, 2022 Glutamate excitotoxicity may contribute to retinal ganglion cell (RGC) degeneration in glaucoma and other optic neuropathies, leading to irreversible blindness.
Dongli Zhuang +3 more
doaj +1 more source
Various facets of excitotoxicity
Exploration of Neuroprotective Therapy, 2022 Aim: Excitotoxicity results from unusually increased activation of excitatory amino acid receptors leading to neuronal death. Since glutamate is the main excitatory neurotransmitter in the central nervous system, it is also the most common ...
Talita Glaser +10 more
doaj +1 more source
Glutamate excitotoxicity: Potential therapeutic target for ischemic stroke.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022 Glutamate-mediated excitotoxicity is an important mechanism leading to post ischemic stroke damage. After acute stroke, the sudden reduction in cerebral blood flow is most initially followed by ion transport protein dysfunction and disruption of ion ...
Zihuan Shen +8 more
semanticscholar +1 more source
Biochemical Pharmacology, 2021 Epilepsy is a complex neurological syndrome characterized by seizures resulting from neuronal hyperexcitability and sudden and synchronized bursts of electrical discharges.
Jennifer L. Green +2 more
semanticscholar +1 more source
Ischemia-Triggered Glutamate Excitotoxicity From the Perspective of Glial Cells
Frontiers in Cellular Neuroscience, 2020 A plethora of neurological disorders shares a final common deadly pathway known as excitotoxicity. Among these disorders, ischemic injury is a prominent cause of death and disability worldwide.
Denisa Belov Kirdajova +3 more
semanticscholar +1 more source