Results 1 to 10 of about 54,476 (302)
Neurotoxicity and Underlying Mechanisms of Endogenous Neurotoxins
International Journal of Molecular Sciences, 2021 Endogenous and exogenous neurotoxins are important factors leading to neurodegenerative diseases. In the 1980s, the discovery that 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) contributes to Parkinson’s disease (PD) symptoms led to new research ...
Nafissa Ismail +2 more
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Neurotoxins Acting at Synaptic Sites: A Brief Review on Mechanisms and Clinical Applications
Toxins, 2022 Neurotoxins generally inhibit or promote the release of neurotransmitters or bind to receptors that are located in the pre- or post-synaptic membranes, thereby affecting physiological functions of synapses and affecting biological processes.
Kunming Zhou +4 more
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Prediction of presynaptic and postsynaptic neurotoxins by combining various Chou’s pseudo components
Scientific Reports, 2017 Presynaptic and postsynaptic neurotoxins are two groups of neurotoxins. Identification of presynaptic and postsynaptic neurotoxins is an important work for numerous newly found toxins.
Haiyan Huo +5 more
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Frontiers in Aging Neuroscience, 2021 Accruing evidence supports the hypothesis that memory deficits in early Alzheimer Disease (AD) might be due to synaptic failure caused by accumulation of intracellular amyloid beta (Aβ) oligomers, then secreted to the extracellular media.
Martín Habif +14 more
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What Are the Neurotoxins in Hemotoxic Snake Venoms?
International Journal of Molecular Sciences, 2023 Snake venoms as tools for hunting are primarily aimed at the most vital systems of the prey, especially the nervous and circulatory systems. In general, snakes of the Elapidae family produce neurotoxic venoms comprising of toxins targeting the nervous ...
A. Osipov, Y. Utkin
semanticscholar +1 more source
Defining the role of post-synaptic α-neurotoxins in paralysis due to snake envenoming in humans
Cellular and Molecular Life Sciences, 2018 Wayne Hodgson +2 more
exaly +2 more sources
Discovery of novel peptide neurotoxins from sea anemone species
Frontiers in Bioscience-Landmark, 2021 As primitive metazoa, sea anemones are rich in various bioactive peptide neurotoxins. These peptides have been applied to neuroscience research tools or directly developed as marine drugs.
Jinxing Fu +3 more
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Toxicology and pharmacology of botulinum and tetanus neurotoxins: an update
Archives of Toxicology, 2022 Tetanus and botulinum neurotoxins cause the neuroparalytic syndromes of tetanus and botulism, respectively, by delivering inside different types of neurons, metalloproteases specifically cleaving the SNARE proteins that are essential for the release of ...
M. Pirazzini, C. Montecucco, O. Rossetto
semanticscholar +1 more source
Neurology and Therapy, 2023 Introduction Although acute and preventive treatments for migraine are commonly given in combination, data on the real-world effectiveness of ubrogepant as an acute treatment when used with an anti-calcitonin gene-related peptide (CGRP) monoclonal ...
Richard B. Lipton +7 more
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Polyvalent Snake Antivenoms: Production Strategy and Their Therapeutic Benefits
Toxins, 2023 Snake envenomation remains an important yet neglected medical problem in many countries, with around five million people affected, and over a hundred thousand deaths annually. Plasma-derived antivenoms are the main therapeutic agent available. Monovalent
Kavi Ratanabanangkoon
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