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Neurotoxins from Marine Dinoflagellates: A Brief Review

Marine Drugs, 2008
Dinoflagellates are not only important marine primary producers and grazers, but also the major causative agents of harmful algal blooms. It has been reported that many dinoflagellate species can produce various natural toxins.
Da-Zhi Wang
exaly   +2 more sources

Early Long-Term Memory Impairment and Changes in the Expression of Synaptic Plasticity-Associated Genes, in the McGill-R-Thy1-APP Rat Model of Alzheimer's-Like Brain Amyloidosis

Frontiers in Aging Neuroscience, 2021
Accruing evidence supports the hypothesis that memory deficits in early Alzheimer Disease (AD) might be due to synaptic failure caused by accumulation of intracellular amyloid beta (Aβ) oligomers, then secreted to the extracellular media.
Martín Habif, Sonia Do Carmo, María Verónica Báez, Natalia Claudia Colettis, Magalí Cecilia Cercato, Daniela Alejandra Salas, María Florencia Acutain, Caterina Laura Sister, Valeria Laura Berkowicz, María Pilar Canal, Tomás González Garello, A. Claudio Cuello, A. Claudio Cuello, A. Claudio Cuello, Diana Alicia Jerusalinsky   +14 more
doaj   +1 more source

Discovery of novel peptide neurotoxins from sea anemone species

Frontiers in Bioscience-Landmark, 2021
As primitive metazoa, sea anemones are rich in various bioactive peptide neurotoxins. These peptides have been applied to neuroscience research tools or directly developed as marine drugs.
Jinxing Fu, Yanling Liao, Ai-Hua Jin, Bingmiao Gao   +3 more
doaj   +1 more source

Real-World Use of Ubrogepant as Acute Treatment for Migraine with an Anti-Calcitonin Gene-Related Peptide Monoclonal Antibody: Results from COURAGE

Neurology and Therapy, 2023
Introduction Although acute and preventive treatments for migraine are commonly given in combination, data on the real-world effectiveness of ubrogepant as an acute treatment when used with an anti-calcitonin gene-related peptide (CGRP) monoclonal ...
Richard B. Lipton, Janette Contreras-De Lama, Daniel Serrano, Ella Engstrom, Nicolai D. Ayasse, Weijie Poh, François Cadiou, Aubrey Manack Adams   +7 more
doaj   +1 more source

Polyvalent Snake Antivenoms: Production Strategy and Their Therapeutic Benefits

Toxins, 2023
Snake envenomation remains an important yet neglected medical problem in many countries, with around five million people affected, and over a hundred thousand deaths annually. Plasma-derived antivenoms are the main therapeutic agent available. Monovalent
Kavi Ratanabanangkoon
doaj   +1 more source

Soluble Epoxide Hydrolase and Brain Cholesterol Metabolism

Frontiers in Molecular Neuroscience, 2020
The bifunctional enzyme soluble epoxide hydrolase (sEH) is found in all regions of the brain. It has two different catalytic activities, each assigned to one of its terminal domains: the C-terminal domain presents hydrolase activity, whereas the N ...
Michelle Flores Domingues, Michelle Flores Domingues, Natalia Callai-Silva, Natalia Callai-Silva, Angela Regina Piovesan, Celia Regina Carlini, Celia Regina Carlini, Celia Regina Carlini   +7 more
doaj   +1 more source

Voltage-Gated Sodium Channels: A Prominent Target of Marine Toxins

Marine Drugs, 2021
Voltage-gated sodium channels (VGSCs) are considered to be one of the most important ion channels given their remarkable physiological role. VGSCs constitute a family of large transmembrane proteins that allow transmission, generation, and propagation of
Rawan Mackieh, Rita Abou-Nader, Rim Wehbe, César Mattei, Christian Legros, Ziad Fajloun, Jean Marc Sabatier   +6 more
doaj   +1 more source

In Vitro Effects of Paralytic Shellfish Toxins and Lytic Extracellular Compounds Produced by Alexandrium Strains on Hemocyte Integrity and Function in Mytilus edulis

Toxins, 2021
Harmful effects caused by the exposure to paralytic shellfish toxins (PSTs) and bioactive extracellular compounds (BECs) on bivalves are frequently difficult to attribute to one or the other compound group. We evaluate and compare the distinct effects of
Virginia Angélica Bianchi, Ulf Bickmeyer, Urban Tillmann, Bernd Krock, Annegret Müller, Doris Abele   +5 more
doaj   +1 more source

Botulism in Cattle: A Case Report of an Outbreak in Sardinia (Italy)

Animals, 2023
Clostridium botulinum is the main causative agent of botulism in humans and animals. The ingestion of the botulinum neurotoxin, usually types C and D, has been shown to produce disease (neurological symptoms) in most botulism cases in cattle.
Luigia Pinna, Annamaria Coccollone, Marcella Maxia, Luca Bano, Concetta Scalfaro, Daniela Mandas, Manuele Liciardi   +6 more
doaj   +1 more source

Application of botulinum toxin type A in gummy smile: case report

RGO: Revista Gaúcha de Odontologia, 2019
Gummy smile is one of the major complaints of patients, due to its influence on the self-esteem. It is known that it has a multifactorial cause and can be present in the excessive vertical growth of the maxilla, excessive labial contraction, short upper ...
David Costa MOREIRA, Francielle Silva POSSIDÔNIO, Fabio Silveira de SOUZA, Angela Mitie Otta KINOSHITA, Elcia Maria Varize SILVEIRA   +4 more
doaj   +1 more source