Results 1 to 10 of about 7,783 (143)
, 2009 A selective neurotoxin takes many forms: as an antibody to a neurotrophin, as an alkylator, as an excitotoxin, as a blocker of requisite neuronal excitation during ontogenetic development, as a generator of oxidative stress, as an inhibitor of vital intraneuronal processes, and as an agent adversely affecting a host of multiple sites in neurons ...
Kostrzewa, Richard M. +1 more
core +5 more sources
Neurotoxins Affecting Neuroexocytosis
Physiological Reviews, 2000 Nerve terminals are specific sites of action of a very large number of toxins produced by many different organisms. The mechanism of action of three groups of presynaptic neurotoxins that interfere directly with the process of neurotransmitter release is reviewed, whereas presynaptic neurotoxins acting on ion channels are not dealt with here.
SCHIAVO G. +2 more
core +8 more sources
Neurotoxicity and Underlying Mechanisms of Endogenous Neurotoxins
International Journal of Molecular Sciences, 2021 Endogenous and exogenous neurotoxins are important factors leading to neurodegenerative diseases. In the 1980s, the discovery that 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) contributes to Parkinson’s disease (PD) symptoms led to new ...
Nafissa Ismail +2 more
exaly +2 more sources
Antipruritic Effects of Botulinum Neurotoxins [PDF]
Toxins, 2018 This review explores current evidence to demonstrate that botulinum neurotoxins (BoNTs) exert antipruritic effects. Both experimental and clinical conditions in which botulinum neurotoxins have been applied for pruritus relief will be presented and ...
Parisa Gazerani
exaly +2 more sources
Journal of Toxicology: Toxin Reviews, 2002 Tetanus (TeNT) and botulinum (BoNTs) neurotoxins are powerful toxins endowed with a specific zinc-endopeptidase activity. Targets of these neurotoxins have been identified as synaptic members of the SNARE proteins, which are involved in the exocytosis of neurotransmitters at the synapse.
Verastegui, C. +4 more
openaire +5 more sources
On Botulinum Neurotoxin Variability [PDF]
mBio, 2015 The rapidly growing number of botulinum neurotoxin sequences poses the problem of the possible evolutionary significance of the variability of these superpotent neurotoxins for toxin-producing Clostridium species. To progress in the understanding of this
Cesare Montecucco, Maria Berica Rasotto
doaj +4 more sources
Different mechanism of blockade of neuroexocytosis by presynaptic neurotoxins
Toxicology Letters, 2004 Nerve terminals are specific sites of action of a very large number of toxins produced by many different organisms. The presynaptic neurotoxins which interfere directly with the process of neurotransmitter release can be grouped in three large ...
Cesare Montecucco, Ornella Rossetto
exaly +1 more source
Frontiers in Aging Neuroscience, 2021 Accruing evidence supports the hypothesis that memory deficits in early Alzheimer Disease (AD) might be due to synaptic failure caused by accumulation of intracellular amyloid beta (Aβ) oligomers, then secreted to the extracellular media.
Martín Habif +14 more
doaj +1 more source
Discovery of novel peptide neurotoxins from sea anemone species
Frontiers in Bioscience-Landmark, 2021 As primitive metazoa, sea anemones are rich in various bioactive peptide neurotoxins. These peptides have been applied to neuroscience research tools or directly developed as marine drugs.
Jinxing Fu +3 more
doaj +1 more source
Neurology and Therapy, 2023 Introduction Although acute and preventive treatments for migraine are commonly given in combination, data on the real-world effectiveness of ubrogepant as an acute treatment when used with an anti-calcitonin gene-related peptide (CGRP) monoclonal ...
Richard B. Lipton +7 more
doaj +1 more source