Results 1 to 10 of about 156,189 (261)

Improving ancient DNA genome assembly [PDF]

PeerJ, 2017
Most reconstruction methods for genomes of ancient origin that are used today require a closely related reference. In order to identify genomic rearrangements or the deletion of whole genes, de novo assembly has to be used.
Alexander Seitz, Kay Nieselt
doaj   +2 more sources

Identification and characterization of a novel enhancer in the HTLV-1 proviral genome

Nature Communications, 2022
Human T-cell leukemia virus type 1 (HTLV-1) is an oncogenic virus with constantly active antisense transcription from the proviral genome. Here, Matsuo et al.
Misaki Matsuo, Takaharu Ueno, Kazuaki Monde, Kenji Sugata, Benjy Jek Yang Tan, Akhinur Rahman, Paola Miyazato, Kyosuke Uchiyama, Saiful Islam, Hiroo Katsuya, Shinsuke Nakajima, Masahito Tokunaga, Kisato Nosaka, Hiroyuki Hata, Atae Utsunomiya, Jun-ichi Fujisawa, Yorifumi Satou   +16 more
doaj   +1 more source

HTLV-1 persistence and leukemogenesis: A game of hide-and-seek with the host immune system

Frontiers in Immunology, 2022
Human T-cell leukemia virus type 1 (HTLV-1), a retrovirus which mainly infects CD4+ T cells and causes adult T-cell leukemia/lymphoma (ATL), is primarily transmitted via direct cell-to-cell transmission.
Benjy J. Y. Tan, Kenji Sugata, Masahiro Ono, Yorifumi Satou   +3 more
doaj   +1 more source

High-depth spatial transcriptome analysis by photo-isolation chemistry

Nature Communications, 2021
Spatial analysis of RNAseq data is important. Here the authors report a method for transcriptome profiling combined with photo-isolation chemistry to allow determination of expression profiles specifically from photo-irradiated regions of interest which ...
Mizuki Honda, Shinya Oki, Ryuichi Kimura, Akihito Harada, Kazumitsu Maehara, Kaori Tanaka, Chikara Meno, Yasuyuki Ohkawa   +7 more
doaj   +1 more source

Single-Cell Molecular Characterization to Partition the Human Glioblastoma Tumor Microenvironment Genetic Background

Cells, 2022
Background: Glioblastoma (GB) is a devastating primary brain malignancy. The recurrence of GB is inevitable despite the standard treatment of surgery, chemotherapy, and radiation, and the median survival is limited to around 15 months.
Francesca Lessi, Sara Franceschi, Mariangela Morelli, Michele Menicagli, Francesco Pasqualetti, Orazio Santonocito, Carlo Gambacciani, Francesco Pieri, Filippo Aquila, Paolo Aretini, Chiara Maria Mazzanti   +10 more
doaj   +1 more source

Molecular tumor analysis and liquid biopsy: a feasibility investigation analyzing circulating tumor DNA in patients with central nervous system lymphomas

BMC Cancer, 2019
Background Central nervous system lymphomas (CNSL) is a devastating disease. Currently, a confirmatory biopsy is required prior to treatment. Objective Our investigation aims to prove the feasibility of a minimally-invasive diagnostic approach for the ...
Anne-Katrin Hickmann, Maximilian Frick, Dirk Hadaschik, Florian Battke, Markus Bittl, Oliver Ganslandt, Saskia Biskup, Dennis Döcker   +7 more
doaj   +1 more source

NF-κB activity during pancreas development regulates adult β-cell mass by modulating neonatal β-cell proliferation and apoptosis

Cell Death Discovery, 2021
NF-κB is a well-characterized transcription factor, widely known for its roles in inflammation and immune responses, as well as in control of cell division and apoptosis. However, its function in β-cells is still being debated, as it appears to depend on
Dror Sever, Anat Hershko-Moshe, Rohit Srivastava, Roy Eldor, Daniel Hibsher, Hadas Keren-Shaul, Ido Amit, Federico Bertuzzi, Lars Krogvold, Knut Dahl-Jørgensen, Iddo Z. Ben-Dov, Limor Landsman, Danielle Melloul   +12 more
doaj   +1 more source

Author Correction: Morpho-molecular identification and first report of Fusarium equiseti in causing chilli wilt from Kashmir (Northern Himalayas)

Scientific Reports, 2021
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Ammarah Hami, Rovidha S. Rasool, Nisar A. Khan, Sheikh Mansoor, Mudasir A. Mir, Nazeer Ahmed, Khalid Z. Masoodi   +6 more
doaj   +1 more source

Tumor mutation burden and circulating tumor DNA in combined CTLA-4 and PD-1 antibody therapy in metastatic melanoma – results of a prospective biomarker study

Journal for ImmunoTherapy of Cancer, 2019
Background Metastasized or unresectable melanoma has been the first malignant tumor to be successfully treated with checkpoint inhibitors. Nevertheless, about 40–50% of the patients do not respond to these treatments and severe side effects are observed ...
Andrea Forschner, Florian Battke, Dirk Hadaschik, Martin Schulze, Stephanie Weißgraeber, Chung-Ting Han, Maria Kopp, Maximilian Frick, Bernhard Klumpp, Nicola Tietze, Teresa Amaral, Peter Martus, Tobias Sinnberg, Thomas Eigentler, Ulrike Keim, Claus Garbe, Dennis Döcker, Saskia Biskup   +17 more
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Morpho-molecular identification and first report of Fusarium equiseti in causing chilli wilt from Kashmir (Northern Himalayas)

Scientific Reports, 2021
Chilli (Capsicum annuum L.) is one of the most significant vegetable and spice crop. Wilt caused by Fusarium Sp. has emerged as a serious problem in chilli production.
Ammarah Hami, Rovidha S. Rasool, Nisar A. Khan, Sheikh Mansoor, Mudasir A. Mir, Nazeer Ahmed, Khalid Z. Masoodi   +6 more
doaj   +1 more source