Results 21 to 30 of about 213,758 (264)

Identifying spatial domain by adapting transcriptomics with histology through contrastive learning

, 2023
Recent advances in spatial transcriptomics have enabled measurements of gene expression at cell/spot resolution meanwhile retaining both the spatial information and the histology images of the tissues.
Yin, Rui, Luo, Mai, Yu, Weijiang, Pan, Zixiang, Chen, Jianing, Lu, Yutong, Zeng, Yuansong, Yang, Yuedong   +7 more
core   +1 more source

Rare Variants in Neurodegeneration Associated Genes Revealed by Targeted Panel Sequencing in a German ALS Cohort

Frontiers in Molecular Neuroscience, 2016
Amyotrophic lateral sclerosis (ALS) is a progressive fatal multisystemic neurodegenerative disorder caused by preferential degeneration of upper and lower motor neurons.
Stefanie Krüger, Florian Battke, Andrea Sprecher, Marita Munz, Marita Munz, Matthis Synofzik, Matthis Synofzik, Ludger Schöls, Ludger Schöls, Thomas Gasser, Thomas Gasser, Torsten Grehl, Johannes Prudlo, Johannes Prudlo, Saskia Biskup, Saskia Biskup   +15 more
doaj   +1 more source

The Envelope (E) Protein of SARS-CoV-2 as a Pharmacological Target

Viruses, 2023
The COVID-19 pandemic caused by the SARS-CoV-2 virus is still a global health concern. Several spike (S) protein-based vaccines have been developed that efficiently protect the human population against severe forms of COVID-19.
Teresa Santos-Mendoza
doaj   +1 more source

HTLV-1 contains a high CG dinucleotide content and is susceptible to the host antiviral protein ZAP

Retrovirology, 2019
Background Human T cell leukaemia virus type 1 (HTLV-1) is a retrovirus associated with human diseases such as adult T-cell leukaemia/lymphoma and HTLV-1 associated myelopathy/tropical spastic paraparesis.
Paola Miyazato, Misaki Matsuo, Benjy J. Y. Tan, Michiyo Tokunaga, Hiroo Katsuya, Saiful Islam, Jumpei Ito, Yasuhiro Murakawa, Yorifumi Satou   +8 more
doaj   +1 more source

Understanding the Immunopathology of HTLV-1-Associated Adult T-Cell Leukemia/Lymphoma: A Comprehensive Review

Biomolecules, 2023
Human T-cell leukemia virus type-1 (HTLV-1) causes adult T-cell leukemia/lymphoma (ATL). HTLV-1 carriers have a lifelong asymptomatic balance between infected cells and host antiviral immunity; however, 5–10% of carriers lose this balance and develop ATL.
Shingo Nakahata, Daniel Enriquez-Vera, M. Ishrat Jahan, Kenji Sugata, Yorifumi Satou   +4 more
doaj   +1 more source

Fusarium chlamydosporum, causing wilt disease of chili (Capsicum annum L.) and brinjal (Solanum melongena L.) in Northern Himalayas: a first report

Scientific Reports, 2022
Chili (Capsicum annuum L.) and brinjal (Solanum melongena L.) are the most widely grown solanaceous crops in the world. However, their production has reduced over several years due to the attack of various fungal and bacterial pathogens and various ...
Tasmeen J. Parihar, Mohd. Yaseen Sofi, Rovidha S. Rasool, Sehla Khursheed, Zahoor A. Bhat, Khursheed Hussain, Bhagyashree Dhekale, Sajad Majeed Zargar, Asma S. Hakak, Mehraj D. Shah, F. A. Nehvi, M. Ashraf Bhat, M. N. Khan, Khalid Z. Masoodi   +13 more
doaj   +1 more source

Transcriptomics-based characterization of the toxicity of ZnO nanoparticles against chronic myeloid leukemia cells

, 2020
Introduction: Zinc oxide nanoparticles (ZnO NPs) have recently attracted attention as potential anti-cancer agents. To the best of our knowledge, the toxicity of ZnO NPs against human chronic myeloid leukemia cells (K562 cell line) has not been studied ...
Saleh AlGhamdi (8279064), Ameen S Alwashmi (16286720), Raid S Al-Baradie (16286711), Christopher Pepper (4467913), Faisal A Alzahrani (16286717), Fahad A Alhumaydhi (12898472), Naif Khalaf Alharbi (13222356), Rajendran Vijayakumar (16286705), Waleed Al Abdulmonem (12183925), Mariappan Premanathan (16286708), Wael Alturaiki (13146834), Suliman A Alsagaby (16286702), Suresh Mickymaray (2628832), Mohammad A Aziz (16286714)   +13 more
core   +1 more source

Global Array-Based Transcriptomics from Minimal Input RNA Utilising an Optimal RNA Isolation Process Combined with SPIA cDNA Probes [PDF]

, 2011
Background: Technical advances in the collection of clinical material, such as laser capture microdissection and cell sorting, provide the advantage of yielding more refined and homogenous populations of cells.
Feuerstein, Giora, Goddard Catharine, Kennedy Laura, Jacqueline Howie, Kennedy, Laura, Giora Feuerstein, Goddard, Catharine; id_orcid, Gino Miele, Struthers Allan, Godfrey Valerie, Lang Chim, Helen Dennis, Mahesh Pauriah, Godfrey, Valerie, Howie, Jacqueline, Chim Lang, Feuerstein Giora, Struthers, Allan, Laura Kennedy, Lang, Chim; id_orcid, Miele Gino, Valerie Godfrey, Dennis Helen, Pauriah, Maheshwar, Crowther Daniel, Miele, Gino, Howie Jacqueline, Crowther, Daniel; id_orcid, Allan Struthers, Daniel Crowther, Dennis, Helen, Pauriah Mahesh, Catharine Goddard   +32 more
core   +2 more sources

Multigenerational Exposure to Nano‐TiO2 Induces Ageing as a Stress Response Mitigated by Environmental Interactions

Advanced NanoBiomed Research, 2021
Despite their ubiquity in personal care products, the health implications of titanium dioxide (TiO2) nanomaterials (NMs) are under strenuous investigation for their potential as a carcinogen, whereas other evidence has shown links with premature ageing ...
Laura-Jayne A. Ellis, Stephen Kissane, Elijah Hoffman, Eugenia Valsami-Jones, James B. Brown, John K. Colbourne, Iseult Lynch   +6 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source