Results 41 to 50 of about 225,084 (264)

Human Pulmonary Tuberculosis: Understanding the Immune Response in the Bronchoalveolar System

Biomolecules, 2022
Mycobacterium tuberculosis, the causal agent of one of the most devastating infectious diseases worldwide, can evade or modulate the host immune response and remain dormant for many years. In this review, we focus on identifying the local immune response
María Teresa Herrera, Silvia Guzmán-Beltrán, Karen Bobadilla, Teresa Santos-Mendoza, Mario Alberto Flores-Valdez, Luis Horacio Gutiérrez-González, Yolanda González   +6 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Transcriptomics of wheat interacting with Septoria tritici (Mycosphaerella graminicola)

, 2012
Transcriptomics of wheat interacting with Septoria tritici (Mycosphaerella graminicola)Transcriptomics of wheat interacting with Septoria tritici (Mycosphaerella ...
Audeon, C., Barloy, Dominique, D., Lafarge, S., Morel, J.B., Marcel, T., Paillard, S., Deller, S., Gobbato, E., Pichon, J.P., Corbeau, C., Lebrun, M.H.   +10 more
core   +2 more sources

Emergence of Fusarium incarnatum and Fusarium avenaceum in wilt affected solanaceous crops of the Northern Himalayas

Scientific Reports
The objective of this study was to identify and characterize the fungal pathogens responsible for wilt diseases in solanaceous crops, specifically tomato, brinjal, and chili, in the Kashmir valley.
Tasmeen J. Parihar, Madeeha Naik, Shafqat Mehraj, Syed Inam ul Haq, Maqsooda Perveen, Ishfaq Ahmed Malla, Taniya Abid, Nadia Gul, Khalid Z. Masoodi   +8 more
doaj   +1 more source

Histone H3.3 sub-variant H3mm7 is required for normal skeletal muscle regeneration

Nature Communications, 2018
Incorporation of histone H3 variant H3.3 into chromatin regulates transcription. Here the authors find that H3.3 sub-variant H3mm7 is required for skeletal muscle regeneration and that H3mm7 nucleosomes are unstable and exhibit higher mobility, with ...
Akihito Harada, Kazumitsu Maehara, Yusuke Ono, Hiroyuki Taguchi, Kiyoshi Yoshioka, Yasuo Kitajima, Yan Xie, Yuko Sato, Takeshi Iwasaki, Jumpei Nogami, Seiji Okada, Tetsuro Komatsu, Yuichiro Semba, Tatsuya Takemoto, Hiroshi Kimura, Hitoshi Kurumizaka, Yasuyuki Ohkawa   +16 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Transcriptomics analysis of baker's yeast under freezing stress

, 2020
ABY3：Transcriptomics analysis of baker's yeast fermented for half an hour at 30℃； ABY+S：Transcriptomics analysis of baker’s yeast overexpressing SNF1 gene after fermentation for half an hour at 30℃ FABY3：Transcriptomics analysis of baker’s yeast after ...
Meng, L
core   +2 more sources

Suppression of NFAT5-mediated Inflammation and Chronic Arthritis by Novel κB-binding Inhibitors

EBioMedicine, 2017
Nuclear factor of activated T cells 5 (NFAT5) has been implicated in the pathogenesis of various human diseases, including cancer and arthritis. However, therapeutic agents inhibiting NFAT5 activity are currently unavailable. To discover NFAT5 inhibitors,
Eun-Jin Han, Hyun Young Kim, Naeun Lee, Nam-Hoon Kim, Seung-Ah Yoo, H. Moo Kwon, Dae-Myung Jue, Yune-Jung Park, Chul-Soo Cho, Tran Quang De, Dae Young Jeong, Hee-Jong Lim, Woo Kyu Park, Ge Hyeong Lee, Heeyeong Cho, Wan-Uk Kim   +15 more
doaj   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source