Results 61 to 70 of about 253,829 (285)
Histone H3.3 sub-variant H3mm7 is required for normal skeletal muscle regeneration
Nature Communications, 2018 Incorporation of histone H3 variant H3.3 into chromatin regulates transcription. Here the authors find that H3.3 sub-variant H3mm7 is required for skeletal muscle regeneration and that H3mm7 nucleosomes are unstable and exhibit higher mobility, with ...
Akihito Harada +16 more
doaj +1 more source
Suppression of NFAT5-mediated Inflammation and Chronic Arthritis by Novel κB-binding Inhibitors
EBioMedicine, 2017 Nuclear factor of activated T cells 5 (NFAT5) has been implicated in the pathogenesis of various human diseases, including cancer and arthritis. However, therapeutic agents inhibiting NFAT5 activity are currently unavailable. To discover NFAT5 inhibitors,
Eun-Jin Han +15 more
doaj +1 more source
Totipotency of mouse zygotes extends to single blastomeres of embryos at the four-cell stage
Scientific Reports, 2021 In multicellular organisms, oocytes and sperm undergo fusion during fertilization and the resulting zygote gives rise to a new individual. The ability of zygotes to produce a fully formed individual from a single cell when placed in a supportive ...
Marino Maemura +7 more
doaj +1 more source
Unraveling Heterogeneity in Epithelial Cell Fates of the Mammary Gland and Breast Cancer. [PDF]
, 2019 Fluidity in cell fate or heterogeneity in cell identity is an interesting cell biological phenomenon, which at the same time poses a significant obstacle for cancer therapy.
Doh, Hanna +3 more
core +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Journal of Translational Medicine, 2018 Background Cancer vaccines can effectively establish clinically relevant tumor immunity. Novel sequencing approaches rapidly identify the mutational fingerprint of tumors, thus allowing to generate personalized tumor vaccines within a few weeks from ...
Katja Sonntag +11 more
doaj +1 more source
Regulation of tumor growth by leukocyte-specific protein 1 in T cells
Journal for ImmunoTherapy of Cancer, 2020 Background Clinical efficacy of T cell-based cancer immunotherapy is limited by the lack of T cell infiltration in the tumor mass, especially in solid tumors.
Riri Kwon +7 more
doaj +1 more source
Plant roots : New challenges in a changing world [PDF]
, 2016 Peer ...
Price, Adam H.
core +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Frontiers in Oncology, 2022 BackgroundGlioblastoma (GB) is the most severe form of brain cancer, with a 12-15 month median survival. Surgical resection, temozolomide (TMZ) treatment, and radiotherapy remain the primary therapeutic options for GB, and no new therapies have been ...
Mariangela Morelli +29 more
doaj +1 more source