Results 11 to 20 of about 7,882 (239)

Suramin inhibits the early effects of PLA(2) neurotoxins at mouse neuromuscular junctions: a twitch tension study [PDF]

open access: yes, 2011
Several phospholipase A(2) (PLA(2)) neurotoxins from snake venoms can affect acetylcholine release at the neuromuscular junction. In isolated nerve-muscle preparations three distinct phases have been described for this phenomenon: An initial transient ...
Fathi, Behrooz   +2 more
core   +3 more sources

Polyvalent Snake Antivenoms: Production Strategy and Their Therapeutic Benefits

open access: yesToxins, 2023
Snake envenomation remains an important yet neglected medical problem in many countries, with around five million people affected, and over a hundred thousand deaths annually. Plasma-derived antivenoms are the main therapeutic agent available. Monovalent
Kavi Ratanabanangkoon
doaj   +1 more source

Clostridial neurotoxins [PDF]

open access: yesJournal of Neurology, Neurosurgery & Psychiatry, 2004
The genus Clostridium comprises a number of spore forming Gram positive, rod shaped bacilli. They are found in the intestines of numerous mammalian species including domestic animals, horses, chickens, and humans. They are also widely distributed in the soil and in marine and freshwater sediments.
Goonetilleke A, Harris JB
openaire   +3 more sources

Soluble Epoxide Hydrolase and Brain Cholesterol Metabolism

open access: yesFrontiers in Molecular Neuroscience, 2020
The bifunctional enzyme soluble epoxide hydrolase (sEH) is found in all regions of the brain. It has two different catalytic activities, each assigned to one of its terminal domains: the C-terminal domain presents hydrolase activity, whereas the N ...
Michelle Flores Domingues   +7 more
doaj   +1 more source

Voltage-Gated Sodium Channels: A Prominent Target of Marine Toxins

open access: yesMarine Drugs, 2021
Voltage-gated sodium channels (VGSCs) are considered to be one of the most important ion channels given their remarkable physiological role. VGSCs constitute a family of large transmembrane proteins that allow transmission, generation, and propagation of
Rawan Mackieh   +6 more
doaj   +1 more source

In Vitro Effects of Paralytic Shellfish Toxins and Lytic Extracellular Compounds Produced by Alexandrium Strains on Hemocyte Integrity and Function in Mytilus edulis

open access: yesToxins, 2021
Harmful effects caused by the exposure to paralytic shellfish toxins (PSTs) and bioactive extracellular compounds (BECs) on bivalves are frequently difficult to attribute to one or the other compound group. We evaluate and compare the distinct effects of
Virginia Angélica Bianchi   +5 more
doaj   +1 more source

Application of botulinum toxin type A in gummy smile: case report

open access: yesRGO: Revista Gaúcha de Odontologia, 2019
Gummy smile is one of the major complaints of patients, due to its influence on the self-esteem. It is known that it has a multifactorial cause and can be present in the excessive vertical growth of the maxilla, excessive labial contraction, short upper ...
David Costa MOREIRA   +4 more
doaj   +1 more source

Botulism in Cattle: A Case Report of an Outbreak in Sardinia (Italy)

open access: yesAnimals, 2023
Clostridium botulinum is the main causative agent of botulism in humans and animals. The ingestion of the botulinum neurotoxin, usually types C and D, has been shown to produce disease (neurological symptoms) in most botulism cases in cattle.
Luigia Pinna   +6 more
doaj   +1 more source

Behavioral Tests in Neurotoxin-Induced Animal Models of Parkinson’s Disease

open access: yesAntioxidants, 2020
Currently, neurodegenerative diseases are a major cause of disability around the world. Parkinson’s disease (PD) is the second-leading cause of neurodegenerative disorder after Alzheimer’s disease.
E. Maruthi Prasad, Shih-Ya Hung
doaj   +1 more source

Botulinum toxins and fillers for treatment of the aging face

open access: yesTNOA Journal of Ophthalmic Science and Research, 2017
We present a comprehensive review of how to best use neuro-toxins and fillers to rejuvenate the aging face. With modern neuro-toxins and fillers, it is now possible to achieve an improvement in the aging changes of young, middle-aged, and older patients.
Bhupendra C. K. Patel
doaj   +1 more source

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