Results 21 to 30 of about 21,263 (262)
Discovery of an Insect Neuroactive Helix Ring Peptide from Ant Venom
Toxins, 2023 Ants are among the most abundant terrestrial invertebrate predators on Earth. To overwhelm their prey, they employ several remarkable behavioral, physiological, and biochemical innovations, including an effective paralytic venom.
Valentine Barassé +19 more
doaj +1 more source
Short Linear Motifs Characterizing Snake Venom and Mammalian Phospholipases A2
Toxins, 2021 Snake venom phospholipases A2 (PLA2s) have sequences and structures very similar to those of mammalian group I and II secretory PLA2s, but they possess many toxic properties, ranging from the inhibition of coagulation to the blockage of nerve ...
Caterina Peggion, Fiorella Tonello
doaj +1 more source
Molecular Diversity and Isoform Evolution in Tityus obscurus Venom: Insights from Proteomic Analysis
ToxinsOver millions of years of evolution, natural selection has driven the specialization of predatory and defensive mechanisms in various animal species through the development of poisons and venoms.
Kemellyn Cristina Panchera +4 more
doaj +1 more source
Scorpion Peptides and Ion Channels: An Insightful Review of Mechanisms and Drug Development
Toxins, 2023 The Buthidae family of scorpions consists of arthropods with significant medical relevance, as their venom contains a diverse range of biomolecules, including neurotoxins that selectively target ion channels in cell membranes.
Lais Campelo Mendes +4 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Neurotoxic Alkaloids: Saxitoxin and Its Analogs
Marine Drugs, 2010 Saxitoxin (STX) and its 57 analogs are a broad group of natural neurotoxic alkaloids, commonly known as the paralytic shellfish toxins (PSTs). PSTs are the causative agents of paralytic shellfish poisoning (PSP) and are mostly associated with marine ...
Troco K. Mihali +4 more
doaj +1 more source
Botulinum and Tetanus Neurotoxins
Annual Review of Biochemistry, 2019 Botulinum neurotoxins (BoNTs) and tetanus neurotoxin (TeNT) are the most potent toxins known and cause botulism and tetanus, respectively. BoNTs are also widely utilized as therapeutic toxins. They contain three functional domains responsible for receptor-binding, membrane translocation, and proteolytic cleavage of host proteins required for synaptic ...
Dong, Min +2 more
openaire +4 more sources
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Druggability of Voltage-Gated Sodium Channels—Exploring Old and New Drug Receptor Sites
Frontiers in Pharmacology, 2022 Voltage-gated ion channels are important drug targets because they play crucial physiological roles in both excitable and non-excitable cells. About 15% of clinical drugs used for treating human diseases target ion channels.
Goragot Wisedchaisri +1 more
doaj +1 more source