Results 31 to 40 of about 28,883 (156)
Druggability of Voltage-Gated Sodium Channels—Exploring Old and New Drug Receptor Sites
Frontiers in Pharmacology, 2022 Voltage-gated ion channels are important drug targets because they play crucial physiological roles in both excitable and non-excitable cells. About 15% of clinical drugs used for treating human diseases target ion channels.
Goragot Wisedchaisri +1 more
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, 2009 A selective neurotoxin takes many forms: as an antibody to a neurotrophin, as an alkylator, as an excitotoxin, as a blocker of requisite neuronal excitation during ontogenetic development, as a generator of oxidative stress, as an inhibitor of vital ...
Kostrzewa, R. M., R.M. Kostrzewa
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Survey of Selective Neurotoxins
, 2014 There has been an awareness of nerve poisons from ancient times. At the dawn of the twentieth century, the actions and mechanisms of these poisons were uncovered by modern physiological and biochemical experimentation.
Kostrzewa, Richard M. +1 more
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Predicting Presynaptic and Postsynaptic Neurotoxins by Developing Feature Selection Technique
, 2017 Presynaptic and postsynaptic neurotoxins are proteins which act at the presynaptic and postsynaptic membrane. Correctly predicting presynaptic and postsynaptic neurotoxins will provide important clues for drug-target discovery and drug design.
Yunchun Yang +6 more
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Acta Limnologica BrasiliensiaAim: The aim of this study was to conduct a rapid and comprehensive analysis of the reservoir using physical, chemical and biological variables comprising water and sediment as also to verify if a one-sampling campaign can produce information that is ...
Frederico Guilherme de Souza Beghelli +5 more
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Snake alpha-Neurotoxins and the Nicotinic Acetylcholine Receptor
, 2017 alpha-Neurotoxins from snake venoms act on postsynaptic nicotinic acetylcholine receptors at the neuromuscular junction to produce clinically significant skeletal muscle paralysis following envenomation.
Nirthanan, Selvanayagam +5 more
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Toxins, 2019 This review gives an overview on the development of research on spider venoms with a focus on structure and function of venom components and techniques of analysis.
Nicolas Langenegger +2 more
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Neurotoxins from Snake Venom [PDF]
, 1998 Found within snake venoms are a variety of toxic and nontoxic proteins. The effects of snake venoms depend on all of the components of that venom. However, the lethal effects are usually related to the most potent toxins found within the venom; the two ...
Tu, Anthony T., Anthony T. Tu
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The Dual Prey-Inactivation Strategy of Spiders—In-Depth Venomic Analysis of Cupiennius salei
Toxins, 2019 Most knowledge of spider venom concerns neurotoxins acting on ion channels, whereas proteins and their significance for the envenomation process are neglected.
Lucia Kuhn-Nentwig +4 more
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Toxins, 2020 A critical hurdle in ant venom proteomic investigations is the lack of databases to comprehensively and specifically identify the sequence and function of venom proteins and peptides.
Samira R. Aili +13 more
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