Results 1 to 10 of about 128,459 (218)

Enhanced immunogenicity of COVID-19 RBD fused to mutant scorpion's phospholipase D for vaccine development

New Microbes and New Infections
The management of the global COVID-19 pandemic relies, in part, on the rapid development of preventive vaccines at an unparalleled speed. The infection caused by the coronavirus is facilitated by the spike glycoprotein trimmer located on the surface of ...
Mohammad-Reza Zareinejad, Mahdi Behdani, Mohammad Taghi Goodarzi, Akbar Oghalaie, Mohammad Hosseininejad-Chafi, Kamran Pooshang-Bagheri, Delavar Shahbazzadeh   +6 more
doaj   +1 more source

Diagnosis of Snakebite and the Importance of Immunological Tests in Venom Research

Toxins, 2014
In many cases of envenoming following snake bite, the snake responsible for the accident remains unidentified; this frequently results in difficulty deciding which antivenom to administer to the systemically-envenomed victim, especially when only ...
R. David G. Theakston, Gavin D. Laing
doaj   +1 more source

Survey of Synanthropic Spiders in Ireland Reveals Expansion and Dominance of the Invasive Noble False Widow Steatoda nobilis in Urban Habitats (Araneae: Theridiidae)

Ecology and Evolution
Rapid urbanisation has led several spider species to adapt to synanthropic microhabitats and establish large populations outside of their native ranges.
Brandon L. Collier, Dayle Leonard, Keith Lyons, John P. Dunbar, Colin Lawton, Michel M. Dugon   +5 more
doaj   +1 more source

Varanid Lizard Venoms Disrupt the Clotting Ability of Human Fibrinogen through Destructive Cleavage

Toxins, 2019
The functional activities of Anguimorpha lizard venoms have received less attention compared to serpent lineages. Bite victims of varanid lizards often report persistent bleeding exceeding that expected for the mechanical damage of the bite.
James S. Dobson, Christina N. Zdenek, Chris Hay, Aude Violette, Rudy Fourmy, Chip Cochran, Bryan G. Fry   +6 more
doaj   +1 more source

Isolation and Pharmacological Characterisation of Pre-Synaptic Neurotoxins from Thai and Javanese Russell’s Viper (Daboia siamensis) Venoms

Toxins
The widespread geographical distribution of Russell’s vipers (Daboia spp.) is associated with marked variations in the clinical outcomes of envenoming by species from different countries.
Mimi Lay, Wayne C. Hodgson
doaj   +1 more source

A Taxon-Specific and High-Throughput Method for Measuring Ligand Binding to Nicotinic Acetylcholine Receptors

Toxins, 2019
The binding of compounds to nicotinic acetylcholine receptors is of great interest in biomedical research. However, progress in this area is hampered by the lack of a high-throughput, cost-effective, and taxonomically flexible platform.
Christina N. Zdenek, Richard J. Harris, Sanjaya Kuruppu, Nicholas J. Youngman, James S. Dobson, Jordan Debono, Muzaffar Khan, Ian Smith, Mike Yarski, David Harrich, Charlotte Sweeney, Nathan Dunstan, Luke Allen, Bryan G. Fry   +13 more
doaj   +1 more source

A Comparison of the Efficacy of Antivenoms and Varespladib against the In Vitro Pre-Synaptic Neurotoxicity of Thai and Javanese Russell’s Viper (Daboia spp.) Venoms

Toxins
The heterogeneity in venom composition and potency in disparate Eastern Russell’s viper (Daboia siamensis) populations has repercussions for the efficacy of antivenoms. This is particularly pronounced in geographical areas in which the venom of the local
Mimi Lay, Wayne C. Hodgson
doaj   +1 more source

Canopy Venom: Proteomic Comparison among New World Arboreal Pit-Viper Venoms

Toxins, 2016
Central and South American pitvipers, belonging to the genera Bothrops and Bothriechis, have independently evolved arboreal tendencies. Little is known regarding the composition and activity of their venoms.
Jordan Debono, Chip Cochran, Sanjaya Kuruppu, Amanda Nouwens, Niwanthi W. Rajapakse, Minami Kawasaki, Kelly Wood, James Dobson, Kate Baumann, Mahdokht Jouiaei, Timothy N. W. Jackson, Ivan Koludarov, Dolyce Low, Syed A. Ali, A. Ian Smith, Andrew Barnes, Bryan G. Fry   +16 more
doaj   +1 more source

Affinity enhancement of an anti-VEGF humanized nanobody as a superior candidate to bevacizumab: integrative in silico and in vitro studies

BMC Biotechnology
Background Although nanobodies have superior characteristics to conventional antibodies, their affinities are often lower because of a single interaction site for antigen binding. Therefore, in the current study, a bioinformatics approach was employed to
Mir Salar Kazemi, Seyed Shahriar Arab, Fatemeh Kazemi-Lomedasht, Reza Ahangari Cohan, Fatemeh Zandi, Alireza Shoari, Mohammad Hosseininejad-Chafi, Golnoosh Mahjoobi, Arghavan Ashja Ardalan, Mozhgan Rezaei Kanavi, Mahdi Behdani   +10 more
doaj   +1 more source

Prevalence of Gastrointestinal Parasitic Infections in Captive Snakes, Bangladesh

Veterinary Medicine and Science
Background Gastrointestinal (GI) parasitic infections are a common health concern in captive snakes, potentially affecting their well‐being. This study aimed to determine the prevalence and associated risk factors of helminth and protozoan infections in ...
Nazmul Hasan, Sahriar Islam, Mahmudur Rahman, Abdul Auawal, Md. Mizanur Rahman, Mohammed Noman, Abdullah Abu Sayeed, Mohammad Abdul Alim   +7 more
doaj   +1 more source