Results 41 to 50 of about 123,481 (166)

A nanobody-derived mimotope against VEGF inhibits cancer angiogenesis

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Vascular Endothelial Growth Factor (VEGF) promotes angiogenesis in tumours of various cancers. Monoclonal antibodies and nanobodies are one of the potent agents in the treatment of cancer.
Elmira Karami, Jean-Marc Sabatier, Mahdi Behdani, Shiva Irani, Fatemeh Kazemi-Lomedasht   +4 more
doaj   +1 more source

Predation on a pygmy shrew, Sorex minutus, by the noble false widow spider, Steatoda nobilis

Ecosphere, 2023
The noble false widow spider Steatoda nobilis is a globally invasive species with implications for public health and possibly for native ecosystems. Here, we report on a case of predation on a protected species of vertebrate, a pygmy shrew Sorex minutus ...
Michel M. Dugon, Colin Lawton, Dawn Sturgess, John P. Dunbar   +3 more
doaj   +1 more source

An overview on application of phage display technique in immunological studies

Asian Pacific Journal of Tropical Biomedicine, 2017
Phage display is very strong technique in drug discovery and development. Phage display has many applications in improving the immunological studies. Development of monoclonal antibody, peptides, peptidomimetics and epitope mapping are main application ...
Abbas Rami, Mahdi Behdani, Najmeh Yardehnavi, Mahdi Habibi-Anbouhi, Fatemeh Kazemi-Lomedasht   +4 more
doaj   +1 more source

Enhanced immunogenicity of COVID-19 RBD fused to mutant scorpion's phospholipase D for vaccine development

New Microbes and New Infections
The management of the global COVID-19 pandemic relies, in part, on the rapid development of preventive vaccines at an unparalleled speed. The infection caused by the coronavirus is facilitated by the spike glycoprotein trimmer located on the surface of ...
Mohammad-Reza Zareinejad, Mahdi Behdani, Mohammad Taghi Goodarzi, Akbar Oghalaie, Mohammad Hosseininejad-Chafi, Kamran Pooshang-Bagheri, Delavar Shahbazzadeh   +6 more
doaj   +1 more source

Survey of Synanthropic Spiders in Ireland Reveals Expansion and Dominance of the Invasive Noble False Widow Steatoda nobilis in Urban Habitats (Araneae: Theridiidae)

Ecology and Evolution
Rapid urbanisation has led several spider species to adapt to synanthropic microhabitats and establish large populations outside of their native ranges.
Brandon L. Collier, Dayle Leonard, Keith Lyons, John P. Dunbar, Colin Lawton, Michel M. Dugon   +5 more
doaj   +1 more source

Diagnosis of Snakebite and the Importance of Immunological Tests in Venom Research

Toxins, 2014
In many cases of envenoming following snake bite, the snake responsible for the accident remains unidentified; this frequently results in difficulty deciding which antivenom to administer to the systemically-envenomed victim, especially when only ...
R. David G. Theakston, Gavin D. Laing
doaj   +1 more source

Varanid Lizard Venoms Disrupt the Clotting Ability of Human Fibrinogen through Destructive Cleavage

Toxins, 2019
The functional activities of Anguimorpha lizard venoms have received less attention compared to serpent lineages. Bite victims of varanid lizards often report persistent bleeding exceeding that expected for the mechanical damage of the bite.
James S. Dobson, Christina N. Zdenek, Chris Hay, Aude Violette, Rudy Fourmy, Chip Cochran, Bryan G. Fry   +6 more
doaj   +1 more source

An Appetite for Destruction: Detecting Prey-Selective Binding of α-Neurotoxins in the Venom of Afro-Asian Elapids

Toxins, 2020
Prey-selective venoms and toxins have been documented across only a few species of snakes. The lack of research in this area has been due to the absence of suitably flexible testing platforms.
Richard J. Harris, Christina N. Zdenek, David Harrich, Nathaniel Frank, Bryan G. Fry   +4 more
doaj   +1 more source

A Taxon-Specific and High-Throughput Method for Measuring Ligand Binding to Nicotinic Acetylcholine Receptors

Toxins, 2019
The binding of compounds to nicotinic acetylcholine receptors is of great interest in biomedical research. However, progress in this area is hampered by the lack of a high-throughput, cost-effective, and taxonomically flexible platform.
Christina N. Zdenek, Richard J. Harris, Sanjaya Kuruppu, Nicholas J. Youngman, James S. Dobson, Jordan Debono, Muzaffar Khan, Ian Smith, Mike Yarski, David Harrich, Charlotte Sweeney, Nathan Dunstan, Luke Allen, Bryan G. Fry   +13 more
doaj   +1 more source

Isolation and Pharmacological Characterisation of Pre-Synaptic Neurotoxins from Thai and Javanese Russell’s Viper (Daboia siamensis) Venoms

Toxins
The widespread geographical distribution of Russell’s vipers (Daboia spp.) is associated with marked variations in the clinical outcomes of envenoming by species from different countries.
Mimi Lay, Wayne C. Hodgson
doaj   +1 more source