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Pharmacological Actions of Potassium Channel Openers on Voltage-Gated Potassium Channels [PDF]

open access: yesPharmaceuticals
Background/Objectives: Potassium (K+) channels are essential transmembrane proteins that regulate ion flow, playing a critical role in regulating action potentials and neuronal transmission.
Michael T. McCoy   +3 more
doaj   +4 more sources

When Is a Potassium Channel Not a Potassium Channel?

open access: yesFunction, 2022
Ever since they were first observed in Purkinje fibers of the heart, funny channels have had close connections to potassium channels. Indeed, funny channels were initially thought to produce a potassium current in the heart called IK2.
Eric Accili
doaj   +3 more sources

VKCDB: Voltage-gated potassium channel database

open access: yesBMC Bioinformatics, 2004
Background The family of voltage-gated potassium channels comprises a functionally diverse group of membrane proteins. They help maintain and regulate the potassium ion-based component of the membrane potential and are thus central to many critical ...
Gallin Warren J, Li Bin
doaj   +2 more sources

Inactivation in the potassium channel KcsA

open access: yesJournal of Structural Biology: X, 2019
Inactivation, the slow cessation of transmission after activation, is a general feature of potassium channels. It is essential for their function, and malfunctions in inactivation leads to numerous pathologies.
Yunyao Xu, Ann E. McDermott
doaj   +3 more sources

Potassium channel‐mediated NO‐induced vasodilation during maturation: Dominance of Kv7 channels [PDF]

open access: yesFASEB BioAdvances
Maturation represents a process characterized by adaptive changes, particularly in the circulatory system. However, it is not known whether, in neonates, potassium channels contribute to NO‐induced vasorelaxation at all and, if so, which potassium ...
Anastasia A. Shvetsova   +4 more
doaj   +2 more sources

Pharmacological Characterization of a Recombinant Mitochondrial ROMK2 Potassium Channel Expressed in Bacteria and Reconstituted in Planar Lipid Bilayers

open access: yesMembranes, 2023
In the inner mitochondrial membrane, several potassium channels that play a role in cell life and death have been identified. One of these channels is the ATP-regulated potassium channel (mitoKATP).
Milena Krajewska   +3 more
doaj   +1 more source

Neonatal exposure to sevoflurane caused learning and memory impairment via dysregulating SK2 channel endocytosis

open access: yesScience Progress, 2021
Numerous studies have demonstrated that anesthetics’ exposure to neonates imposes toxicity on the developing brain but the underlying mechanisms need to be further elucidated.
Wentao Ke, Xiangdi Yu, Yutong Gao
doaj   +1 more source

Unique features of two potassium channels, OsKAT2 and OsKAT3, expressed in rice guard cells. [PDF]

open access: yesPLoS ONE, 2013
Potassium is the most abundant cation and a myriad of transporters regulate K(+) homeostasis in plant. Potassium plays a role as a major osmolyte to regulate stomatal movements that control water utility of land plants.
Hyunsik Hwang   +10 more
doaj   +1 more source

Current Challenges of Mitochondrial Potassium Channel Research

open access: yesFrontiers in Physiology, 2022
In this paper, the current challenges of mitochondrial potassium channels research were critically reviewed. Even though recent progress in understanding K+ traffic in mitochondria has been substantial, some basic issues of this process remain unresolved.
Bogusz Kulawiak, Adam Szewczyk
doaj   +1 more source

Drunk potassium channels [PDF]

open access: yesEuropace, 2011
We report the case of a 42-year-old woman who was admitted due to alcohol induced dehydration leading to cardiac symptoms. On physical examination severe hypokalaemia and long QT syndrome were apparent. During potassium (K+) supplementation we simultaneously observed QT interval recovery.
Amir M, Nia   +3 more
openaire   +2 more sources

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