Results 31 to 40 of about 274,660 (308)

High conductance anion channel in Schwann cell vesicles from rat spinal roots [PDF]

, 1992
Potassium uptake, possibly together with chloride, is one of the presumed functions of Schwann cells in the peripheral nervous system. However, the presence of chloride channels has not been demonstrated in adult Schwann cells.
Quasthoff, Stefan, Stefan Quasthoff, Peter Grafe, Strupp, Michael, Grafe, Peter, Michael Strupp   +5 more
core   +1 more source

Putative Structural and Functional Coupling of the Mitochondrial BKCa Channel to the Respiratory Chain. [PDF]

PLoS ONE, 2013
Potassium channels have been found in the inner mitochondrial membranes of various cells. These channels regulate the mitochondrial membrane potential, the matrix volume and respiration. The activation of these channels is cytoprotective.
Piotr Bednarczyk, Mariusz R Wieckowski, Malgorzata Broszkiewicz, Krzysztof Skowronek, Detlef Siemen, Adam Szewczyk   +5 more
doaj   +1 more source

Effects of Single Nucleotide Polymorphisms in Human KCNMA1 on BK Current Properties

Frontiers in Molecular Neuroscience, 2019
BK Ca2+-activated K+ channels are important regulators of membrane excitability. Multiple regulatory mechanisms tailor BK current properties across tissues, such as alternative splicing, posttranslational modifications, and auxiliary subunits.
Amber E. Plante, Michael H. Lai, Jessica Lu, Andrea L. Meredith   +3 more
doaj   +1 more source

Reduction of Kcnt1 is therapeutic in mouse models of SCN1A and SCN8A epilepsy

Frontiers in Neuroscience, 2023
Developmental and epileptic encephalopathies (DEEs) are severe seizure disorders with inadequate treatment options. Gain- or loss-of-function mutations of neuronal ion channel genes, including potassium channels and voltage-gated sodium channels, are ...
Sophie F. Hill, Sophie F. Hill, Paymaan Jafar-Nejad, Frank Rigo, Miriam H. Meisler, Miriam H. Meisler, Miriam H. Meisler   +6 more
doaj   +1 more source

Potassium Channel Mechanics [PDF]

Neuron, 2001
What is the moving part that switches an ion channel's current on and off? In this issue of Neuron del Camino and Yellen (2001) exploit scanning cysteine mutagenesis and sulfhydryl reagents to show that the intracellular end of the S6 helices forms a mechanical gate for the Shaker potassium channel.
openaire   +2 more sources

Mechanism of resveratrol-induced relaxation in the human gallbladder

BMC Complementary and Alternative Medicine, 2017
Background Resveratrol is a polyphenolic compound extracted from plants and is also a constituent of red wine. Resveratrol produces relaxation of vascular smooth muscle and may prevent cardiovascular diseases.
Ching-Chung Tsai, Ming-Che Lee, Shu-Leei Tey, Ching-Wen Liu, Shih-Che Huang   +4 more
doaj   +1 more source

Phα1β interaction with the Kv11.1 potassium channel in HEK293 cells transfected with the human ERG channel [PDF]

Journal of Venomous Animals and Toxins including Tropical Diseases
Background: This study examines the impact of Phα1β, a spider peptide derived from the venom of Phoneutria nigriventer, on the Kv11.1 potassium channel in HEK293 cells transfected with the human ERG potassium channel.
João B. Calixto, Adara Aurea dos Santos, Juliano Ferreira, Alessandra Hubner Souza, Célio José de Castro Junior, Marcus Vinicius Gomez   +5 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Extracellular blockade of K(+) channels by TEA : results from molecular dynamics simulations of the KcsA channel [PDF]

, 2001
TEA is a classical blocker of K(+) channels. From mutagenesis studies, it has been shown that external blockade by TEA is strongly dependent upon the presence of aromatic residue at Shaker position 449 which is located near the extracellular entrance to ...
Simon Bernèche, Benoît Roux, Crouzy, S., Roux, B., Serge Crouzy, Bernèche, S.   +5 more
core   +1 more source

Nitric Oxide and Small and Intermediate Calcium-Activated Potassium Channels Mediate the Vasodilation Induced by Apigenin in the Resistance Vessels of Hypertensive Rats

Molecules
Background: Apigenin (4′,5,7-trihydroxyflavone), a flavonoid with potential cardiovascular benefits, has unclear mechanisms of action. This study investigates its effects on vascular function in Spontaneously Hypertensive Rats (SHRs). Methods: Mesenteric
Lislaine Maria Klider, Maria Luiza Fidelis da Silva, Gustavo Ratti da Silva, João Ricardo Cray da Costa, Marcia Alessandra Arantes Marques, Emerson Luiz Botelho Lourenço, Francislaine Aparecida dos Reis Lívero, Jane Manfron, Arquimedes Gasparotto Junior   +8 more
doaj   +1 more source