Results 11 to 20 of about 79,124 (218)

Insulin Protects Cortical Neurons Against Glutamate Excitotoxicity

Frontiers in Neuroscience, 2019
Glutamate excitotoxicity is implicated in the pathogenesis of numerous diseases, such as stroke, traumatic brain injury, and Alzheimer’s disease, for which insulin resistance is a concomitant condition, and intranasal insulin treatment is believed to be ...
Irina Krasil’nikova, Alexander Surin, Alexander Surin, Elena Sorokina, Andrei Fisenko, Dmitry Boyarkin, Maxim Balyasin, Anna Demchenko, Igor Pomytkin, Igor Pomytkin, Vsevolod Pinelis   +10 more
doaj   +1 more source

Micronutrients May Be a Unique Weapon Against the Neurotoxic Triad of Excitotoxicity, Oxidative Stress and Neuroinflammation: A Perspective

Frontiers in Neuroscience, 2021
Excitotoxicity has been implicated in many neurological disorders and is a leading cause of oxidative stress and neuroinflammation in the nervous system.
Kathleen F. Holton
doaj   +1 more source

A circuit-dependent ROS feedback loop mediates glutamate excitotoxicity to sculpt the Drosophila motor system

eLife, 2019
Overproduction of reactive oxygen species (ROS) is known to mediate glutamate excitotoxicity in neurological diseases. However, how ROS burdens can influence neural circuit integrity remains unclear.
Jhan-Jie Peng, Shih-Han Lin, Yu-Tzu Liu, Hsin-Chieh Lin, Tsai-Ning Li, Chi-Kuang Yao   +5 more
doaj   +1 more source

Endocytosis of GluN2B-containing NMDA receptor mediates NMDA-induced excitotoxicity

Molecular Pain, 2017
N-methyl-D-aspartate (NMDA) receptor overactivation is involved in neuronal damage after stroke. However, the mechanism underlying NMDA receptor-mediated excitotoxicity remains unclear.
Yu Wu, Changwan Chen, Qian Yang, Mingfei Jiao, Shuang Qiu   +4 more
doaj   +1 more source

Inhibition of the mitochondrial pyruvate carrier protects from excitotoxic neuronal death. [PDF]

, 2017
Glutamate is the dominant excitatory neurotransmitter in the brain, but under conditions of metabolic stress it can accumulate to excitotoxic levels.
Andreyev, Alexander Y, Bloodgood, Brenda L, Buren, Caodu, Cordes, Thekla, Divakaruni, Ajit S, Fields, Jerel A, Li, Edward, Martyniuk, Kelly, Metallo, Christian M, Murphy, Anne N, Raymond, Lynn A, Reynolds, Ian J, Wallace, Martina   +12 more
core   +1 more source

Ambient but not local lactate underlies neuronal tolerance to prolonged glucose deprivation [PDF]

, 2018
Neurons require a nearly constant supply of ATP. Glucose is the predominant source of brain ATP, but the direct effects of prolonged glucose deprivation on neuronal viability and function remain unclear.
Mennerick, Steven, Shu, Hong-Jin, Sobieski, Courtney, Warikoo, Natasha   +3 more
core   +3 more sources

Network Pharmacology and Experimental Verification to Unveil the Mechanism of N-Methyl-D-Aspartic Acid Rescue Humantenirine-Induced Excitotoxicity

Metabolites, 2023
Gelsemium is a medicinal plant that has been used to treat various diseases, but it is also well-known for its high toxicity. Complex alkaloids are considered the main poisonous components in Gelsemium.
Xue-Jia Qi, Chong-Yin Huang, Meng-Ting Zuo, Meng-Die Gong, Si-Juan Huang, Mo-Huan Tang, Zhao-Ying Liu   +6 more
doaj   +1 more source

Imbalance of p75(NTR)/TrkB protein expression in Huntington's disease: Implication for neuroprotective therapies [PDF]

, 2013
Neuroprotective therapies based on brain-derived neurotrophic factor (BDNF) administration have been proposed for Huntington's disease (HD) treatment. However, our group has recently reported reduced levels of TrkB in HD mouse models and HD human brain ...
Alberch, J., Brito, V., Del Toro Ruiz, D., Gines, S., Giralt, A., Puigdellivol, M.   +5 more
core   +1 more source

Permissive role for mGlu1 metabotropic glutamate receptors in excitotoxic retinal degeneration [PDF]

, 2017
Neuroprotection is an unmet need in eye disorders characterized by retinal ganglion cell (RGC) death, such as prematurity-induced retinal degeneration, glaucoma, and age-related macular degeneration.
Battaglia, Giuseppe, Beneventano, Martina, Bruno, Valeria, Bucci, Domenico, Di Pietro, Paola, Liberatore, Francesca, Madonna, Michele, Mascio, Giada, Nicoletti, Ferdinando, Puliti, Alda Maria, Romano, Maria Rosaria   +10 more
core   +1 more source

Potential protective roles of phytochemicals on glutamate-induced neurotoxicity: A review [PDF]

Iranian Journal of Basic Medical Sciences, 2020
Glutamate, as an essential neurotransmitter, has been thought to have different roles in the central nervous system (CNS), including nerve regeneration, synaptogenesis, and neurogenesis.
Amir R. Afshari, Sahar Fanoudi, Arezoo Rajabian, Hamid Reza Sadeghnia, Hamid Mollazadeh, Azar Hosseini   +5 more
doaj   +1 more source