Results 11 to 20 of about 12,017 (197)

Nicorandil mitigates glutamate excitotoxicity in primary cultured neurons [PDF]

Medicine Science
Excitotoxicity, caused by the excessive release of glutamate, leads to the activation of the apoptotic process, making it a crucial factor in age-related neurodegenerative diseases.
Muhammed Sait Ertugrul, Ufuk Okkay, Yesim Yeni, Sidika Genc, Ozge Balpinar, Irmak Ferah Okkay, Ahmet Hacimuftuoglu   +6 more
doaj   +2 more sources

Neuroprotective Effects of Daphnetin against NMDA Receptor-Mediated Excitotoxicity

Molecules, 2014
The accumulation of glutamate can excessively activate the N-methyl-d-aspartate (NMDA) receptors and cause excitotoxicity. Daphnetin (Dap), a coumarin derivative, is a protein kinase inhibitor that exhibits antioxidant and neuroprotective properties ...
Le Yang, Qi Yang, Kun Zhang, Yu-Jiao Li, Yu-Mei Wu, Shui-Bing Liu, Lian-He Zheng, Ming-Gao Zhao   +7 more
doaj   +2 more sources

Retrograde transport of neurotrophin receptor TrkB-FL induced by excitotoxicity regulates Golgi stability and is a target for stroke neuroprotection

Cell Death and Disease
Excitotoxicity, aberrant function of survival pathways dependent on brain-derived neurotrophic factor (BDNF), and disruption of the Golgi complex are shared pathological hallmarks in relevant neurological diseases, including stroke.
Gema María Esteban-Ortega, Elena Torres-Campos, Margarita Díaz-Guerra   +2 more
doaj   +2 more sources

Neuroprotection by Mitochondrial NAD Against Glutamate-Induced Excitotoxicity [PDF]

Cells
Excitotoxicity is a pathological process that occurs in many neurological diseases, such as stroke or epilepsy, and is characterized by the extracellular accumulation of high concentrations of glutamate or other excitatory amino acids (EAAs ...
Bruna S. Paiva, Diogo Neves, Diogo Tomé, Filipa J. Costa, Inês C. Bruno, Diogo Trigo, Raquel M. Silva, Ramiro D. Almeida   +7 more
doaj   +2 more sources

Excitotoxicity Revisited: Mitochondria on the Verge of a Nervous Breakdown [PDF]

, 2021
Excitotoxicity is likely to occur in pathological scenarios in which mitochondrial function is already compromised, shaping neuronal responses to glutamate.
Filadi, Riccardo, Pizzo, P, Plotegher, Nicoletta, Plotegher, N, Duchen, MR, Filadi, R, Pizzo, Paola, Duchen, Michael R, Plotegher Nicoletta, Filadi Riccardo, Pizzo Paola, Duchen Michael R, Riccardo Filadi, Nicoletta Plotegher, Paola Pizzo, Michael R. Duchen   +15 more
core   +2 more sources

A circuit-dependent ROS feedback loop mediates glutamate excitotoxicity to sculpt the Drosophila motor system

eLife, 2019
Overproduction of reactive oxygen species (ROS) is known to mediate glutamate excitotoxicity in neurological diseases. However, how ROS burdens can influence neural circuit integrity remains unclear.
Jhan-Jie Peng, Shih-Han Lin, Yu-Tzu Liu, Hsin-Chieh Lin, Tsai-Ning Li, Chi-Kuang Yao   +5 more
doaj   +1 more source

Death Associated Protein Kinase (DAPK) -mediated neurodegenerative mechanisms in nematode excitotoxicity [PDF]

, 2015
Background: Excitotoxicity (the toxic overstimulation of neurons by the excitatory transmitter Glutamate) is a central process in widespread neurodegenerative conditions such as brain ischemia and chronic neurological diseases.
Towfiq Ahmed, Ahmed, Towfiq, Maha Salama, Daniel Asemota, Mahmud, Tauhid, Uzair Amjad, Tauhid Mahmud, Feldmann, Katherine Genevieve, BakKeung Ko, Amjad, Uzair, Katherine Genevieve Feldmann, JunHyung An, Del Rosario, John S, Asemota, Daniel, Ko, BakKeung, Shirley Mei, Mano, Itzhak, Mei, Shirley, John S Del Rosario, An, JunHyung, Salama, Maha, Itzhak Mano   +21 more
core   +3 more sources

Endocytosis of GluN2B-containing NMDA receptor mediates NMDA-induced excitotoxicity

Molecular Pain, 2017
N-methyl-D-aspartate (NMDA) receptor overactivation is involved in neuronal damage after stroke. However, the mechanism underlying NMDA receptor-mediated excitotoxicity remains unclear.
Yu Wu, Changwan Chen, Qian Yang, Mingfei Jiao, Shuang Qiu   +4 more
doaj   +1 more source

Axonal degeneration induced by glutamate-excitotoxicity is mediated by necroptosis [PDF]

, 2018
Neuronal excitotoxicity induced by glutamate leads to cell death and functional impairment in a variety of central nervous system pathologies. Glutamate-mediated excitotoxicity triggers neuronal apoptosis in the cell soma as well as degeneration of axons
Court, F. A., Hernandez, D. E., Bronfman, F. C., Court G., Felipe, Moya Alvarado, Guillermo Adrián, Catalán, Romina J., Moya-Alvarado, G., Salvadores, N. A., Salvadores, Natalia A., Hernández, Diego E., Bronfman C., Francisca, Catalan, R. J.   +11 more
core   +1 more source

Network Pharmacology and Experimental Verification to Unveil the Mechanism of N-Methyl-D-Aspartic Acid Rescue Humantenirine-Induced Excitotoxicity

Metabolites, 2023
Gelsemium is a medicinal plant that has been used to treat various diseases, but it is also well-known for its high toxicity. Complex alkaloids are considered the main poisonous components in Gelsemium.
Xue-Jia Qi, Chong-Yin Huang, Meng-Ting Zuo, Meng-Die Gong, Si-Juan Huang, Mo-Huan Tang, Zhao-Ying Liu   +6 more
doaj   +1 more source