Results 11 to 20 of about 80,747 (355)
Molecular mechanisms of ischemia and glutamate excitotoxicity [PDF]
Life Science, 2023 Excitotoxicity is classically defined as the neuronal damage caused by the excessive release of glutamate, and subsequent activation of excitatory plasma membrane receptors. In the mammalian brain, this phenomenon is mainly driven by excessive activation
Salazar, Ivan L. +7 more
core +2 more sources
Insulin Protects Cortical Neurons Against Glutamate Excitotoxicity
Frontiers in Neuroscience, 2019 Glutamate excitotoxicity is implicated in the pathogenesis of numerous diseases, such as stroke, traumatic brain injury, and Alzheimer’s disease, for which insulin resistance is a concomitant condition, and intranasal insulin treatment is believed to be ...
Irina Krasil’nikova +10 more
doaj +2 more sources
eLife, 2019 Overproduction of reactive oxygen species (ROS) is known to mediate glutamate excitotoxicity in neurological diseases. However, how ROS burdens can influence neural circuit integrity remains unclear.
Jhan-Jie Peng +5 more
doaj +2 more sources
Mechanism of Zinc Excitotoxicity: A Focus on AMPK
Frontiers in Neuroscience, 2020 Over the last 20 years, it has been shown that complex signaling cascades are involved in zinc excitotoxicity. Free zinc rapidly induces PKC activation, which causes reactive oxygen species (ROS) production at least in part through NADPH oxidase. It also
Yang-Hee Kim, Jae-Won Eom, Jae-Young Koh
doaj +2 more sources
The Susceptibility of Retinal Ganglion Cells to Glutamatergic Excitotoxicity Is Type-Specific
Frontiers in Neuroscience, 2019 Retinal ganglion cells (RGCs) are the only output neurons that conduct visual signals from the eyes to the brain. RGC degeneration occurs in many retinal diseases leading to blindness and increasing evidence suggests that RGCs are susceptible to various ...
Ian Christensen +10 more
doaj +2 more sources
Excitotoxicity Revisited: Mitochondria on the Verge of a Nervous Breakdown [PDF]
Trends in Neurosciences, 2021 Excitotoxicity is likely to occur in pathological scenarios in which mitochondrial function is already compromised, shaping neuronal responses to glutamate.
Filadi, Riccardo +7 more
core +2 more sources
Axonal degeneration induced by glutamate-excitotoxicity is mediated by necroptosis [PDF]
Journal of Cell Science, 2018 Neuronal excitotoxicity induced by glutamate leads to cell death and functional impairment in a variety of central nervous system pathologies. Glutamate-mediated excitotoxicity triggers neuronal apoptosis in the cell soma as well as degeneration of axons
Court, F. A. +11 more
core +4 more sources
Neuroprotection by Mitochondrial NAD Against Glutamate-Induced Excitotoxicity
CellsExcitotoxicity is a pathological process that occurs in many neurological diseases, such as stroke or epilepsy, and is characterized by the extracellular accumulation of high concentrations of glutamate or other excitatory amino acids (EAAs ...
Bruna S. Paiva +7 more
doaj +2 more sources
Molecular Neurodegeneration, 2017 Background Hyperexcitability of neuronal networks can lead to excessive release of the excitatory neurotransmitter glutamate, which in turn can cause neuronal damage by overactivating NMDA-type glutamate receptors and related signaling pathways.
Takashi Miyamoto +7 more
doaj +2 more sources
Excitotoxicity and stroke: Identifying novel targets for neuroprotection
Progress in neurobiology, 2014 Excitotoxicity, the specific type of neurotoxicity mediated by glutamate, may be the missing link between ischemia and neuronal death, and intervening the mechanistic steps that lead to excitotoxicity can prevent stroke damage. Interest in excitotoxicity
Wang, Yu Tian +2 more
core +2 more sources