Results 41 to 50 of about 80,747 (355)

Age Associated Sleep Loss: A Trigger For Alzheimer’s Disease

Psychiatry and Clinical Psychopharmacology, 2021
Alzheimer’s disease (AD) is an untreatable, multifactorial, chronic, progressive, neurodegenerative disorder, which is the principal cause of dementia throughout the world and the fourth most important cause of death in developed economies after cancer,
Vivek Kumar Sharma, Preety Sharma, Rahul Deshmukh, Ranjit Singh   +3 more
doaj   +1 more source

Is L-Glutamate Toxic to Neurons and Thereby Contributes to Neuronal Loss and Neurodegeneration? A Systematic Review

, 2022
L-glutamate (L-Glu) is a nonessential amino acid, but an extensively utilised excitatory neurotransmitter with critical roles in normal brain function. Aberrant accumulation of L-Glu has been linked to neurotoxicity and neurodegeneration.
Al-Nasser, Maryam N., Wayne G. Carter, Maryam N. AL-Nasser, Carter, Wayne G., Mellor, Ian R., Ian R. Mellor   +5 more
core   +1 more source

Inappropriate Intrusion of an Axonal Mitochondrial Anchor into Dendrites Causes Neurodegeneration

Cell Reports, 2019
Summary: Syntaphilin (SNPH) is a major mitochondrial anchoring protein targeted to axons and excluded from dendrites. In this study, we provide in vivo evidence that this spatial specificity is lost in Shiverer (Shi) mice, a model for progressive ...
Dinesh C. Joshi, Chuan-Li Zhang, Lavanya Babujee, Jason D. Vevea, Benjamin K. August, Zu-Hang Sheng, Edwin R. Chapman, Timothy M. Gomez, Shing Yan Chiu   +8 more
doaj   +1 more source

Glutamate-Mediated Excitotoxicity in the Pathogenesis and Treatment of Neurodevelopmental and Adult Mental Disorders

International Journal of Molecular Sciences
Glutamate is the main excitatory neurotransmitter in the brain wherein it controls cognitive functional domains and mood. Indeed, brain areas involved in memory formation and consolidation as well as in fear and emotional processing, such as the ...
Noemi Nicosia, Mattia Giovenzana, P. Misztak, J. Mingardi, L. Musazzi   +4 more
semanticscholar   +1 more source

Tau exacerbates excitotoxic brain damage in an animal model of stroke

Nature Communications, 2017
Excitotoxicity contributes to neuronal injury following stroke. Here the authors show that tau promotes excitotoxicity by a post-synaptic mechanism, involving site-specific control of ERK activation, in a mouse model of stroke.
Mian Bi, Amadeus Gladbach, Janet van Eersel, Arne Ittner, Magdalena Przybyla, Annika van Hummel, Sook Wern Chua, Julia van der Hoven, Wei S. Lee, Julius Müller, Jasneet Parmar, Georg von Jonquieres, Holly Stefen, Ernesto Guccione, Thomas Fath, Gary D. Housley, Matthias Klugmann, Yazi D. Ke, Lars M. Ittner   +18 more
doaj   +1 more source

The CB1 Cannabinoid Receptor Mediates Excitotoxicity-induced Neural Progenitor Proliferation and Neurogenesis

, 2007
Endocannabinoids are lipid signaling mediators that exert an important neuromodulatory role and confer neuroprotection in several types of brain injury.
Monory, Krisztina, Sendtner, Michael, Romero, Eva, Lutz, Beat, Guzmán Pastor, Manuel, Marsicano, Giovanni, Galve Roperh, Ismael, Aguado Sánchez, Tania, Palazuelos Diego, Javier   +8 more
core   +1 more source

Glutamate and excitotoxicity in central nervous system disorders: ionotropic glutamate receptors as a target for neuroprotection

Neuroprotection
Recent advances in neuroscience have illuminated the central role of glutamate dysregulation in various neurological disorders. The glutamatergic system has emerged as a central player in the pathophysiology of various neurological disorders.
Jorge Y. Magdaleno Roman, C. Chapa González   +1 more
semanticscholar   +1 more source

Revisiting Glutamate Excitotoxicity in Amyotrophic Lateral Sclerosis and Age-Related Neurodegeneration

International Journal of Molecular Sciences
Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disorder. While there are five FDA-approved drugs for treating this disease, each has only modest benefits.
F. J. Arnold, Alexandra F Putka, Urmimala Raychaudhuri, Solomon Hsu, R. Bedlack, C. L. Bennett, A. L. La Spada   +6 more
semanticscholar   +1 more source

Superoxide and Non-ionotropic Signaling in Neuronal Excitotoxicity

Frontiers in Neuroscience, 2020
Excitotoxicity is classically attributed to Ca2+ influx through NMDA receptors (NMDAr), leading to production of nitric oxide by neuronal nitric oxide synthase and superoxide by mitochondria, which react to form highly cytotoxic peroxynitrite.
Jie-jie Wang, R. Swanson
semanticscholar   +1 more source

Excitotoxicity, neuroinflammation and oxidant stress as molecular bases of epileptogenesis and epilepsy-derived neurodegeneration: The role of vitamin E.

Biochimica et Biophysica Acta - Molecular Basis of Disease, 2019
Glutamate-mediated excitotoxicity, neuroinflammation, and oxidative stress are common underlying events in neurodegeneration. This pathogenic "triad" characterizes the neurobiology of epilepsy, leading to seizure-induced cell death, increased ...
P. Ambrogini, P. Torquato, D. Bartolini, M. C. Albertini, D. Lattanzi, M. Di Palma, R. Marinelli, M. Betti, A. Minelli, R. Cuppini, F. Galli   +10 more
semanticscholar   +1 more source