Results 51 to 60 of about 57,791 (292)
Advanced Science, EarlyView.How localized Ca2+ signals orchestrate neural repair remains unclear. Here, we show that TRPC3‐driven calcium microdomains direct nerve repair by coupling spatially confined Ca2+ signals to axon regeneration. This module operates in injured peripheral neurons and correlates with neuroprotection in Parkinson's disease, revealing a spatial logic for ...
Yu Lu +14 more
wiley +1 more source
Serum Magnesium Levels and Lipid Profile in Patients with Epileptic Seizures: A Cross-sectional Study [PDF]
Journal of Clinical and Diagnostic ResearchIntroduction: Recurrent seizures of cerebral origin with episodes of sensory, motor, or autonomic expression, with or without loss of consciousness, are typical symptoms of epilepsy, a chronic neurological condition.
Monika Agrawal +3 more
doaj +1 more source
Frontiers in Neuroscience, 2020 This special issue of Frontiers in Neuroscience-Neurodegeneration celebrates the 50th anniversary of John Olney’s seminal work introducing the concept of excitotoxicity as a mechanism for neuronal cell death.
Elias Aizenman +3 more
doaj +1 more source
Advanced Science, EarlyView.Photobiomodulated microglia release engineered extracellular vesicles that deliver UFL1 to the injured spinal cord. UFL1 competitively binds p53 with MDM2, inhibiting p53 ubiquitination and stabilizing p53 signaling. This dual mechanism simultaneously promotes anti‐inflammatory microglial polarization and directs neural stem cell differentiation toward
Yunxiao Fang +12 more
wiley +1 more source
The metabolic response to excitotoxicity - lessons from single-cell imaging.
, 2015 Excitotoxicity is a pathological process implicated in neuronal death during ischaemia, traumatic brain injuries and neurodegenerative diseases. Excitotoxicity is caused by excess levels of glutamate and over-activation of NMDA or calcium-permeable AMPA ...
Jochen Prehn (7895672) +1 more
core +3 more sources
CD3ζ-Mediated Signaling Protects Retinal Ganglion Cells in Glutamate Excitotoxicity of the Retina
CellsExcessive levels of glutamate activity could potentially damage and kill neurons. Glutamate excitotoxicity is thought to play a critical role in many CNS and retinal diseases.
Rui Du, Ping Wang, Ning Tian
doaj +1 more source
Avaliação do efeito neuroprotetor de lectinas frente à neurotoxicidade glutamatérgica [PDF]
, 2012 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em BioquímicaA excitotoxicidade induzida pela excessiva ativação da neurotransmissão glutamatérgica está envolvida em várias ...
Jacques, Amanda Virtuoso
core
Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma
Advanced Science, EarlyView.This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert +8 more
wiley +1 more source
Studies of excitotoxicity in cerebellar granule neurons [PDF]
, 2021 Excitotoxicity is defined as neuronal cell death caused by hyperactivation of ionotropic glutamate receptors (namely NMDA-, AMPA- and KA-receptors).
Sinclair, Colin James
core +2 more sources
Bioenergetics and glutamate excitotoxicity
Progress in Neurobiology, 1996 Bioenergetic defects and abnormalities in glutamate neurotransmission have both been proposed to play important roles in neurological diseases of varying chronology, etiology and pathology. Recent experimental evidence suggests an intimate relationship between these two systems.
J G, Greene, J T, Greenamyre
openaire +2 more sources