Results 71 to 80 of about 80,747 (355)

Microglial CB2 cannabinoid receptors are neuroprotective in Huntington's disease excitotoxicity

, 2009
Cannabinoid-derived drugs are promising agents for the development of novel neuroprotective strategies. Activation of neuronal CB1 cannabinoid receptors attenuates excitotoxic glutamatergic neurotransmission, triggers prosurvival signalling pathways and ...
Azcoitia Elías, Íñigo, Julien, Boris, Romero, Julián, Guzmán Pastor, Manuel, Galve Roperh, Ismael, Palazuelos Diego, Javier, Fernández Ruiz, José Javier, Pazos, Ruth, Sagredo Ezquioga, Onintza, Benito, Cristina, Aguado Sánchez, Tania, Carrasco, Carolina, Resel, Eva   +12 more
core   +1 more source

Excitotoxic inactivation of constitutive oxidative stress detoxification pathway in neurons can be rescued by PKD1

Nature Communications, 2017
Excitotoxicity due to excessive glutamate release causes oxidative stress and neuronal death, and is a feature of many brain diseases. Here the authors show that protein kinase D1 is inactivated by excitotoxicity in a model of stroke and that its ...
Julia Pose-Utrilla, Lucía García-Guerra, Ana Del Puerto, Abraham Martín, Jerónimo Jurado-Arjona, Noelia S. De León-Reyes, Andrea Gamir-Morralla, Álvaro Sebastián-Serrano, Mónica García-Gallo, Leonor Kremer, Jens Fielitz, Christofer Ireson, Mª José Pérez-Álvarez, Isidro Ferrer, Félix Hernández, Jesús Ávila, Marina Lasa, Miguel R. Campanero, Teresa Iglesias   +18 more
doaj   +1 more source

VEGFD Protects Retinal Ganglion Cells and, consequently, Capillaries against Excitotoxic Injury

Molecular Therapy: Methods & Clinical Development, 2020
In the central nervous system, neurons and the vasculature influence each other. While it is well described that a functional vascular system is trophic to neurons and that vascular damage contributes to neurodegeneration, the opposite scenario in which ...
Annabelle Schlüter, Bahar Aksan, Ricarda Diem, Richard Fairless, Daniela Mauceri   +4 more
doaj   +1 more source

Research progress on biomarkers of traumatic brain injury

Animal Models and Experimental Medicine, EarlyView.
Traumatic brain injury: From primary insult to secondary neuroinflammation and degeneration. Abstract Traumatic brain injury (TBI) is a common disorder of the nervous system and has become a leading cause of death and disability worldwide, imposing a substantial burden on patients and their social circles. Its main symptoms include dyskinesia, language
Xuting Shen, Si Cheng, Shuyi Chen, Mengyue Wang, Tangying Li, Weicheng Xu, Yifan Zhang, Ping Yuan, Lei Shi   +8 more
wiley   +1 more source

Serum Magnesium Levels and Lipid Profile in Patients with Epileptic Seizures: A Cross-sectional Study [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Recurrent seizures of cerebral origin with episodes of sensory, motor, or autonomic expression, with or without loss of consciousness, are typical symptoms of epilepsy, a chronic neurological condition.
Monika Agrawal, Shalu Sharma, Astha Goyal, Sarita A Shinde   +3 more
doaj   +1 more source

The Redox Biology of Excitotoxic Processes: The NMDA Receptor, TOPA Quinone, and the Oxidative Liberation of Intracellular Zinc

Frontiers in Neuroscience, 2020
This special issue of Frontiers in Neuroscience-Neurodegeneration celebrates the 50th anniversary of John Olney’s seminal work introducing the concept of excitotoxicity as a mechanism for neuronal cell death.
Elias Aizenman, Ralph H. Loring, Ian J. Reynolds, Paul A. Rosenberg   +3 more
doaj   +1 more source

New opportunities for bioscaffold‐enabled spinal cord injury repair

BMEMat, EarlyView.
Schematic illustration of bioscaffolds for spinal cord injury repair. We summarize the effects of bioscaffold properties on SCI repair, highlight different types of bioscaffolds, various fabrication strategies, and in vivo transformations for the clinical development of SCI‐repairing bioscaffolds.
Xiaoqing Qi, Yicheng Fu, Zhaoliang Su, Li Li, Subrata Chakrabarti, Peng Li, Yilun Wu, Fang Liu, Teng Gao, Zhifeng Dong, Lei Liu, Pei Cao   +11 more
wiley   +1 more source

Revisiting Excitotoxicity in Traumatic Brain Injury: From Bench to Bedside

Pharmaceutics, 2022
Traumatic brain injury (TBI) is one of the leading causes of morbidity and mortality. Consequences vary from mild cognitive impairment to death and, no matter the severity of subsequent sequelae, it represents a high burden for affected patients and for ...
Daniela Baracaldo-Santamaría, Daniel Felipe Ariza-Salamanca, María Gabriela Corrales-Hernández, Maria José Pachón-Londoño, Isabella Hernandez-Duarte, Carlos-Alberto Calderon-Ospina   +5 more
doaj   +1 more source

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, EarlyView.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source

Suppressing pro-inflammatory prostaglandin signaling attenuates excitotoxicity-associated neuronal inflammation and injury

Neuropharmacology, 2019
&NA; Glutamate receptor‐mediated excitotoxicity is a common pathogenic process in many neurological conditions including epilepsy. Prolonged seizures induce elevations in extracellular glutamate that contribute to excitotoxic damage, which in turn can ...
Jianxiong Jiang, Ying Yu, E. R. Kinjo, Yifeng Du, Hoang-Phuong Nguyen, R. Dingledine   +5 more
semanticscholar   +1 more source